![Phosphate and phosphonate derivatives of 7-amino-5-thio-thiazolo[4,5-d]pyrimidines and their use in treating conditions associated with elevated levels of CX3CR1 and/or CX3CL1](/docs/US/2022-05-24/US11339183B2/abs.jpg.600x600.jpg)
- 专利标题： Phosphate and phosphonate derivatives of 7-amino-5-thio-thiazolo[4,5-d]pyrimidines and their use in treating conditions associated with elevated levels of CX3CR1 and/or CX3CL1
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申请号： US17372125申请日： 2021-07-09
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公开(公告)号： US11339183B2公开(公告)日： 2022-05-24
- 发明人: Jan Vågberg , Styrbjörn Byström , Elisabeth Olsson , Mattias Jönsson
- 申请人： KANCERA AB
- 申请人地址： SE Banvaktsvagen
- 专利权人： KANCERA AB
- 当前专利权人： KANCERA AB
- 当前专利权人地址： SE Banvaktsvagen
- 代理机构： Parker Highlander PLLC
- 优先权： GB1811169 20180706
- 主分类号： C07F9/6561
- IPC分类号： C07F9/6561 ; A61K9/08 ; A61K31/685 ; A61K31/70 ; A61K45/06
![Phosphate and phosphonate derivatives of 7-amino-5-thio-thiazolo[4,5-d]pyrimidines and their use in treating conditions associated with elevated levels of CX3CR1 and/or CX3CL1](/abs-image/US/2022/05/24/US11339183B2/abs.jpg.150x150.jpg)
摘要：
There is provided a compound of formula I, wherein R1, R2, Q1 and are as defined herein, which compounds are useful in the treatment of diseases and disorders associated with elevated levels of CX3CR1 and/or CX3CL1, in particular acute and/or chronic inflammation, eye diseases, lung diseases, skin diseases, joint and/or bone diseases, autoimmune diseases, cardiovascular diseases, metabolic diseases, brain diseases, neurodegenerative diseases, pain, cancer, liver diseases, kidney diseases, gastrointestinal diseases, human immunodeficiency virus and mood disorders.
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