公开(公告)号：US20230193207A1

公开(公告)日：2023-06-22

申请号：US18046787

申请日：2022-10-14

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde ,  Jasmine Harris

IPC: C12N5/0775 ,  A61P35/00 ,  A61P11/00

CPC classification number: C12N5/0668 ,  A61P35/00 ,  A61P11/00 ,  C12N2506/45 ,  C12N2501/60

Abstract: Cell-based therapies based on mesenchymal stem cells (MSCs) are described.

公开(公告)号：US11492600B2

公开(公告)日：2022-11-08

申请号：US16562497

申请日：2019-09-06

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N5/00 ,  C12N5/074 ,  C12N5/095 ,  C12N5/077 ,  C12N5/071 ,  C12N5/0789

Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US11466293B2

公开(公告)日：2022-10-11

申请号：US16567059

申请日：2019-09-11

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N15/87 ,  C08K5/5399 ,  C12N5/074 ,  H01L31/048 ,  C12P21/00 ,  C12N9/16 ,  C12N5/0789 ,  C12N5/077 ,  C12N15/90 ,  C12N9/22 ,  A61K35/28 ,  C08G77/08 ,  A61K35/12

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US11339410B2

公开(公告)日：2022-05-24

申请号：US16654726

申请日：2019-10-16

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C07H21/04 ,  C12N15/63 ,  C12N15/90 ,  A61K31/7115 ,  C12N9/22 ,  C07K14/195 ,  C12N15/10 ,  A61K35/14 ,  A61K38/46 ,  A61K48/00 ,  C12N15/86 ,  G01N33/50 ,  A61K31/70 ,  A61K35/12

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US10982229B2

公开(公告)日：2021-04-20

申请号：US16869232

申请日：2020-05-07

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N15/85 ,  C12N15/87 ,  C08K5/5399 ,  C12N5/074 ,  H01L31/048 ,  C12P21/00 ,  C12N9/16 ,  C12N5/0789 ,  C12N5/077 ,  C12N15/90 ,  C12N9/22 ,  A61K35/28 ,  C08G77/08 ,  A61K35/12

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US10131882B2

公开(公告)日：2018-11-20

申请号：US15947741

申请日：2018-04-06

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N5/00 ,  C12N5/074 ,  C12N5/095 ,  C12N5/077 ,  C12N5/071 ,  C12N5/0789

Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US09770489B2

公开(公告)日：2017-09-26

申请号：US14761461

申请日：2015-01-30

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: A61K48/00 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/00 ,  C12N15/90 ,  A61K38/39 ,  A61K38/38 ,  C12N15/87 ,  A61K38/44 ,  A61K38/45 ,  A61K45/06 ,  A61K31/573 ,  A61K31/575 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/711 ,  A61K9/00 ,  A61K9/127 ,  A61K47/46 ,  A61B18/18 ,  A61M35/00 ,  A61K8/60 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08 ,  A61B18/00

CPC classification number: A61K38/39 ,  A61B18/18 ,  A61B2018/00452 ,  A61B2018/1807 ,  A61K8/606 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/127 ,  A61K31/573 ,  A61K31/575 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K38/38 ,  A61K38/44 ,  A61K38/45 ,  A61K45/06 ,  A61K47/46 ,  A61K48/00 ,  A61K48/005 ,  A61K2800/83 ,  A61K2800/91 ,  A61M35/00 ,  A61Q19/00 ,  A61Q19/008 ,  A61Q19/06 ,  A61Q19/08 ,  C12N15/87 ,  A61K2300/00

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20170267979A1

公开(公告)日：2017-09-21

申请号：US15605513

申请日：2017-05-25

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N5/074 ,  C12N5/071 ,  C12N5/077 ,  C12N5/0789 ,  C12N5/095 ,  C12N5/00

CPC classification number: C12N5/0696 ,  C12N5/0018 ,  C12N5/0625 ,  C12N5/0647 ,  C12N5/0656 ,  C12N5/0657 ,  C12N5/0676 ,  C12N5/0695 ,  C12N2500/25 ,  C12N2500/33 ,  C12N2500/36 ,  C12N2500/84 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2501/998 ,  C12N2506/09 ,  C12N2506/45

Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US20170151285A1

公开(公告)日：2017-06-01

申请号：US15429798

申请日：2017-02-10

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: A61K35/28

CPC classification number: C12N5/0647 ,  A61K35/28 ,  A61K2035/124 ,  C08G77/08 ,  C08K5/5399 ,  C12N5/0657 ,  C12N9/16 ,  C12N9/22 ,  C12N15/87 ,  C12N15/907 ,  C12N2500/25 ,  C12N2500/44 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/2303 ,  C12N2501/26 ,  C12N2501/91 ,  C12N2501/998 ,  C12N2506/09 ,  C12N2800/80 ,  C12P21/00 ,  C12Y301/21 ,  H01L31/048 ,  Y02E10/50 ,  C08L83/04

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US09605278B2

公开(公告)日：2017-03-28

申请号：US15222453

申请日：2016-07-28

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N5/00 ,  C12N15/90 ,  C08K5/5399 ,  H01L31/048 ,  C12N15/87 ,  C12P21/00 ,  C12N9/16 ,  C12N5/0789 ,  C12N5/077 ,  C08G77/08

CPC classification number: C12N5/0647 ,  A61K35/28 ,  A61K2035/124 ,  C08G77/08 ,  C08K5/5399 ,  C12N5/0657 ,  C12N9/16 ,  C12N9/22 ,  C12N15/87 ,  C12N15/907 ,  C12N2500/25 ,  C12N2500/44 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/2303 ,  C12N2501/26 ,  C12N2501/91 ,  C12N2501/998 ,  C12N2506/09 ,  C12N2800/80 ,  C12P21/00 ,  C12Y301/21 ,  H01L31/048 ,  Y02E10/50 ,  C08L83/04

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.