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376 条记录 (耗时 0.054 秒)

    Novel Sulfonamides
    21.
    发明申请
    Novel Sulfonamides 有权
    新型磺酰胺

    公开(公告)号：US20070043090A1

    公开(公告)日：2007-02-22

    申请号：US11426482

    申请日：2006-06-26

    申请人： Robert Burk

    发明人： Robert Burk

    IPC分类号： A61K31/558 ,  C07D333/22 ,  A61K31/44 ,  A61K31/381 ,  C07D307/02

    CPC分类号： C07C311/06 ,  C07C2601/04

    摘要： The present invention provides wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5; R2 is selected from the group consisting of C1-C10 alkyl and (CH2)nOH; R3 is selected from the group consisting of C1-C10 alkyl, heteroaryl, e.g. thienyl, furanyl and pyridyl, phenyl, mono, -di-, tri-substituted phenyl and heteroaryl; R4 and R5 are independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl hydroxyl; m is 0 or an integer from 1 to 3 and n is an integer of from 1 to 4. These compounds are useful in lowering intraocular pressure and/or treating glaucoma or providing neuroprotection to the eye of a human patient.

    摘要翻译： 本发明提供其中R 1选自C 1 -C 10烷氧基，OH和NR 4， / SUP> R＆lt; 5＆gt;; R 2选自C 1 -C 10烷基和（CH 2 N 2）N 2 > n OH; R 3选自C 1 -C 10烷基，杂芳基，例如C 1 -C 6烷基。 噻吩基，呋喃基和吡啶基，苯基，单，二 - ，三取代的苯基和杂芳基; R 4和R 5独立地选自H，C 1 -C 10烷基， C 1 -C 10烷基羟基; C 1 -C 10烷基羟基; m为0或1〜3的整数，n为1〜4的整数。这些化合物可用于降低眼内压和/或治疗青光眼或向人类患者的眼睛提供神经保护作用。

    Novel n-bisaryl- and n-aryl-cycloalkylidenyl-alpha-sulfin- and alpha-sulfonamino acid amides
    25.
    发明申请
    Novel n-bisaryl- and n-aryl-cycloalkylidenyl-alpha-sulfin- and alpha-sulfonamino acid amides 审中-公开
    新的正二芳基 - 和n-芳基 - 环亚烷基-α-亚磺酰基和α-磺酰氨基酰胺

    公开(公告)号：US20040214721A1

    公开(公告)日：2004-10-28

    申请号：US10481967

    申请日：2003-12-17

    发明人： Andre Jeanguenat ,  Clemens Lamberth ,  Martin Zeller

    IPC分类号： A01N041/06

    CPC分类号： A01N41/06 ,  A01N55/00 ,  C07C307/06 ,  C07C311/06 ,  C07C2601/14 ,  C07F7/1804

    摘要： The invention relates to novel pesticidally active N-bisaryl-and N-aryl-cycloalkylidenyl-null-sulfin-and null-sulfonamino acid amides of the general formula I, including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1-C12alkyl; C1-C12alkyl substituted with C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylsulfonyl, C3-C8cycloalkyl, cyano, C1-C6alkoxycarbonyl, C3-C6alkoxycarbonyl, C3-C6alkenyloxycarbonyl or C3-C6alkynyloxycarbonyl; C2-C12alkenyl; C2-C12alkynyl; C1-C12haloalkyl; or a group NR11R12 wherein R11 and R12 are each independently of the other C1-C6alkyl, or together are tetra- or penta-methylene; R2 and R3 ae each independently hydrogen; C1-C8alkyl; C1-C8alkyl substituted with hydroxy, mercapto, C1-C4alkoxy or C1-C4alkylthio; C3-C8alkenyl; C3-C8alkynyl; C3-C8cycloalkyl; C3-C8cycloalkyl-C1-C4alkyl; optionally substituted aryl; optionally substituted heteroaryl; or the two groups R2 and R3 together with the carbon atom to which they are bonded form a three- to eight-membered hydrocarbon ring; A is an optionally substituted saturated or unsaturated C3-C8-cycloalkylidene, optionally substituted phenylidene or optionally substituted saturated or unsaturated heterocyclylidene bridge, R4 and R5 are each independently hydrogen or an organic radicak, and R6 is hydrogen; tri-C1C4alkyl-silyl; di-C1-C4alkyl-phenysilyl; C1-C4alkyl-diphenylsilyl; tri-phenylsilyl; optionally subsituted alkyl; optionally substituted alkenyl or optionally substituted alkynyl. The novel compounds possess plant-protecting properties and are suitable for protecting plants against infestation by phytophathogenic microorganisms. 1

    摘要翻译： 本发明涉及通式I的新型杀虫活性N-二芳基 - 和N-芳基 - 环亚烷基-α-亚磺酰基和α-磺酰氨基酰胺，包括其旋光异构体和这些异构体的混合物，其中n是数 零或一; R1是C1-C12烷基; 被C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基磺酰基，C 3 -C 8环烷基，氰基，C 1 -C 6烷氧基羰基，C 3 -C 6烷氧基羰基，C 3 -C 6烯氧基羰基或C 3 -C 6炔氧基羰基取代的C 1 -C 12烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基; 或NR 11 R 12基团，其中R 11和R 12各自独立地为C 1 -C 6烷基，或一起为四或五亚甲基; R2和R3a各自独立地为氢; C1-C8烷基; 被羟基，巯基，C 1 -C 4烷氧基或C 1 -C 4烷硫基取代的C 1 -C 8烷基; C3-C8链烯基; C3-C8炔基; C 3 -C 8环烷基; C 3 -C 8环烷基-C 1 -C 4烷基; 任选取代的芳基; 任选取代的杂芳基; 或两个R 2和R 3与它们所键合的碳原子一起形成三至八元烃环; A是任选取代的饱和或不饱和的C 3 -C 8 - 亚环烷基，任选取代的亚苯基或任选取代的饱和或不饱和杂环亚烷基桥，R 4和R 5各自独立地为氢或有机基，