公开(公告)号：US20230219015A1

公开(公告)日：2023-07-13

申请号：US18022869

申请日：2021-08-26

申请人： K.D. PHARMA BEXBACH GMBH

发明人： Gideon GIESSELMANN ,  Roberto FRONZONI ,  Denitsa SHOPOVA-GOSPODINOVA ,  Elia RAMOS-TERCERO

IPC分类号： B01D11/02 ,  C07C37/72 ,  C07C51/48 ,  C07D311/80 ,  C07B63/00

CPC分类号： B01D11/0288 ,  C07C37/72 ,  C07C51/48 ,  C07D311/80 ,  C07B63/00 ,  C07C2601/16

摘要： A method for extraction, in which an extraction agent is used for dissolving at least one extraction material out of a substance. The extraction agent includes fatty acid ethyl ester and/or fatty acid methyl ester. In one embodiment the extraction agent is an omega-3 and/or omega-6 fatty acid, preferably EPA, DHA, DPA, ETA, 21:5n3 and/or SDA. In one embodiment the extraction agent includes at least 500 mg/g, preferably at least 700 mg/g of the fatty acid ethyl ester and/or of the fatty acid methyl ester. Expediently, the mixture of substances is a plant material, preferably hemp, and the extraction material is a cannabinoid, preferably CBD and/or THC.

公开(公告)号：US11691043B2

公开(公告)日：2023-07-04

申请号：US17868037

申请日：2022-07-19

申请人： SHANDONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Xiangming Hu ,  Weimin Cheng ,  Bingrui Yan ,  Yanyun Zhao ,  Di Xue ,  Mingyue Wu ,  Zhenglong He ,  Guangxing Bai ,  Zonglei Mou

IPC分类号： A62D1/00 ,  B01D11/02 ,  C09K21/02 ,  C09K21/06 ,  E21F15/00

CPC分类号： A62D1/005 ,  B01D11/0288 ,  C09K21/02 ,  C09K21/06 ,  E21F15/005

摘要： Provided is a multi-functional plugging agent for a coal mine and a preparation method thereof. The preparation method comprises: by taking Ecklonia Kurome Okam as a raw material, mixing an Ecklonia Kurome Okam suspension with phosphorus pentoxide for reaction, then performing biodegradation to obtain an Ecklonia Kurome Okam biological extract, adding urea for neutralization, mixing a neutralization product with an inorganic catalyst and melamine for reaction to obtain a bio-based plugging synergist solution, finally cooling the bio-based plugging synergist solution, and mixing the cooled bio-based plugging synergist solution with a certain amount of pentaerythritol and ammonium polyphosphate to obtain the multi-functional plugging agent for the coal mine based on the Ecklonia Kurome Okam biological extract. According to the invention, not only a coal crack can be effectively plugged for a long time, but also an efficient flame-retardant effect can be achieved in a complete period of coal spontaneous combustion.

公开(公告)号：US11666618B2

公开(公告)日：2023-06-06

申请号：US16338259

申请日：2017-09-28

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Nissim Garti ,  Sharon Garti Levi ,  Rotem Edri

IPC分类号： A61K36/185 ,  A61K9/00 ,  A61K9/70 ,  A61K9/48 ,  A61K9/08 ,  A61K9/107 ,  A61K9/06 ,  A61K47/44 ,  A61K47/14 ,  A61K47/24 ,  A61K47/10 ,  B01D11/02 ,  A61K47/26 ,  A61K31/352

CPC分类号： A61K36/185 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/0073 ,  A61K9/06 ,  A61K9/08 ,  A61K9/1075 ,  A61K9/48 ,  A61K9/7015 ,  A61K9/7023 ,  A61K31/352 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/44 ,  B01D11/0288 ,  A61K2236/00 ,  A61K2236/30

摘要： Provided are methods for selective extraction of cannabinoids, for example cannabidiol (CBD), from a plant source, by using tailored extraction media.

公开(公告)号：US11655208B2

公开(公告)日：2023-05-23

申请号：US17548669

申请日：2021-12-13

申请人： Jiangnan University

发明人： Xiulan Sun ,  Yongli Ye ,  Qianqian Hong ,  Deping Xu ,  Yinzhi Zhang ,  Shuxiang Geng

IPC分类号： C07C249/02 ,  A61K31/15 ,  B01D11/02 ,  A61K36/52 ,  B01D15/12 ,  B01D15/42

CPC分类号： C07C249/02 ,  A61K31/15 ,  A61K36/52 ,  B01D11/0288 ,  B01D11/0292 ,  B01D15/125 ,  B01D15/426

摘要： The present disclosure discloses a 1-carboxy-2-hydroxy-3-iminopropane and an extraction method thereof, and belongs to the technical fields of food, health food and medicine. A method for extracting the 1-carboxy-2-hydroxy-3-iminopropane of the present disclosure includes the following steps: (1) adding a diaphragma juglandis fructus powder into an ethanol solution for extraction and filtration to obtain a supernatant, and conducting concentration on the supernatant under reduced pressure to obtain a walnut alcohol extract; (2) adding a filter residue of step (1) into water for extraction and filtration to obtain a supernatant, and conducting concentration on the supernatant under reduced pressure to obtain a walnut water extract; and (3) mixing the walnut alcohol extract and the water extract to obtain a diaphragma juglandis fructus mixed extract, sequentially conducting elution through an AB-8 type macroporous resin column, an MCI column and an ODS column, and conducting separation to obtain a precipitate, namely the 1-carboxy-2-hydroxy-3-iminopropane. In the present disclosure, the 1-carboxy-2-hydroxy-3-iminopropane in diaphragma juglandis fructus is found for the first time and has great sedation and hypnosis activity.

公开(公告)号：US20190231736A1

公开(公告)日：2019-08-01

申请号：US15929099

申请日：2019-01-31

申请人： Deep Cell Industries, Inc.

发明人： James Gerstenberger ,  Kelly Ogilvie

IPC分类号： A61K31/352 ,  A61K9/16 ,  B01D9/00 ,  B01D11/02 ,  B01D21/00 ,  C07C51/43

CPC分类号： A61K31/352 ,  A61K9/1652 ,  B01D9/0009 ,  B01D11/0288 ,  B01D11/0292 ,  B01D21/009 ,  C07C51/43

摘要： A method of generating an oligosaccharide encapsulated cannabidiol (CBD) formulation includes forming a cannabidiol ethanol mixture comprising ethanol and cannabidiol, forming an oligosaccharide CBD slurry by mixing the oligosaccharide with the cannabidiol ethanol mixture. The slurry is heated and mixed in a pressurized chamber to form a colloidal mixture, which is distributed into a tray as a layer. A cover is added to the tray to form an evaporation vessel, which is heated in a heating chamber. A rapid cooling process is performed on the colloidal mixture layer by removing the cover and spraying pulverized dry ice on the layer. The rapid cooling process is repeated until crystal formation is detected within the layer, the crystals including oligosaccharide encapsulated cannabidiol. An oligosaccharide encapsulated cannabidiol formulation includes cannabidiol and at least one oligosaccharide in a ratio in the range between about 1000:1 to 2200:1 (w/w) of CBD.

公开(公告)号：US20190201809A1

公开(公告)日：2019-07-04

申请号：US16295220

申请日：2019-03-07

申请人： Phytoplant Research S.L.

发明人： Xavier Nadal Roura

IPC分类号： B01D11/02 ,  C07D311/80 ,  B01D15/18 ,  C07C37/72 ,  G01N30/88 ,  C07C51/48 ,  B01D11/04 ,  C07C37/00

CPC分类号： B01D11/0288 ,  B01D11/0203 ,  B01D11/0492 ,  B01D15/1807 ,  B01D15/1892 ,  C07C37/004 ,  C07C37/72 ,  C07C51/48 ,  C07C2601/16 ,  C07D311/80 ,  G01N30/88

摘要： The present specification discloses methods of purifying one or more cannabinoids from a plant material using unique biphasic solvent systems and liquid-liquid chromatography as centrifugation partitioning chromatography (CPC) or counter current chromatography (CCC). The present specification also provides purified cannabinoids such as CBG, CBGA, CBGV, CBD, CBDA, CBDV, THC, THCA and THCV, compositions comprising one or more of these cannabinoids produced by the disclosed method, and methods for treating a disease or condition employing such purified cannabinoids and compositions.

公开(公告)号：US20190195838A1

公开(公告)日：2019-06-27

申请号：US16070898

申请日：2017-01-19

申请人： Waters Technologies Corporation

发明人： Abhijit Tarafder

IPC分类号： G01N30/06 ,  B01D11/02 ,  B01D15/12 ,  G01N1/40

CPC分类号： G01N30/06 ,  B01D11/0203 ,  B01D11/0219 ,  B01D11/028 ,  B01D11/0288 ,  B01D15/12 ,  B01D17/12 ,  G01N1/4055 ,  G01N30/02 ,  G01N30/08 ,  G01N30/20 ,  G01N30/32 ,  G01N30/34 ,  G01N35/1097 ,  G01N2001/4061 ,  G01N2030/009 ,  G01N2030/062 ,  G01N2030/085 ,  G01N2030/328 ,  G01N2030/347 ,  G01N2035/0444

摘要： In a chromatography system, including within the system an extraction vessel which receives a mixture of mobile phase and co-solvent and provides a mixture of mobile phase and co-solvent with sample to a chromatography column to increase sample concentration within the mixture. In addition, adding a reservoir to the chromatography system to form an extraction-pressurization system, wherein the mixture with sample may be collected in the reservoir and may diffuse and equilibrate to an approximately uniform sample concentration before being provided to the chromatography column. Also in addition, providing a plurality of extraction-pressurization systems to allow near-simultaneous extraction of sample and loading of the column, or concurrent extraction and loading by the plurality of extraction-pressurization systems.

公开(公告)号：US20190194138A1

公开(公告)日：2019-06-27

申请号：US16097776

申请日：2018-03-22

申请人： Hunan University of Chinese Medicine

发明人： Shunxiang Li ,  Juan Li

IPC分类号： C07D221/18 ,  B01D11/02 ,  B01D15/08

CPC分类号： C07D221/18 ,  B01D11/0288 ,  B01D15/08 ,  C07B2200/13

摘要： A 7H-azulene [1,2,3-i,j] isoquinolin-7-one compound, a single crystal and a use thereof are provided. The compound has a structure as shown in a formula (I). The present invention obtains a crude extract of Acorus calamus L., then extracts with different polar solvents in sequence and separates column chromatography to obtain a novel alkaloid compound, which is expected to be developed into a novel class of drug exerting neuroprotective effects, so as to prevent and treat senile dementia, stroke and epilepsy diseases.

公开(公告)号：US20190192992A1

公开(公告)日：2019-06-27

申请号：US16291705

申请日：2019-03-04

申请人： Nextleaf Solutions Ltd.

发明人： Ryan Delmoral Ko

IPC分类号： B01D11/02 ,  B01D46/00

CPC分类号： B01D11/0219 ,  A61K2236/31 ,  A61K2236/333 ,  A61K2236/37 ,  A61K2236/39 ,  B01D11/02 ,  B01D11/0207 ,  B01D11/0284 ,  B01D11/0288 ,  B01D11/0296 ,  B01D11/0492 ,  B01D24/007 ,  B01D29/56 ,  B01D35/18 ,  B01D46/0006 ,  B01D2011/007

摘要： A series of vertically oriented filters of decreasing pore size is sealed from the atmosphere. Pressurized gas is used to force the liquid to be filtered through the filters. The filter stages are thermally insulated from ambient temperatures in order to maintain the liquid passing through at a reduced temperature. Each filter stage has a removable lid, which provides convenient access for replacing the filter cartridge, allowing it to be changed without disturbing the thermally insulated sidewalls of the filter stage.

公开(公告)号：US20190076753A1

公开(公告)日：2019-03-14

申请号：US16184574

申请日：2018-11-08

申请人： Natural Extraction Systems, LLC

发明人： C. Russell Thomas

IPC分类号： B01D11/02 ,  B01D1/14 ,  B01D3/34 ,  C11B9/02 ,  C11B1/10 ,  B01D11/00

CPC分类号： B01D11/02 ,  B01D1/14 ,  B01D3/343 ,  B01D11/023 ,  B01D11/028 ,  B01D11/0288 ,  B01D11/0296 ,  B01D2011/007 ,  C11B1/10 ,  C11B9/027

摘要： An apparatus for extracting an oil from plant material includes an extraction chamber for plant material. The plant material is exposed to a heated gas stream with a temperature sufficient to volatilize on oil from the plant material. The gas stream is rapidly cooled to liquefy the oil into entrained droplets. The oil is collected with a collection solvent.