公开(公告)号：US20240317766A1

公开(公告)日：2024-09-26

申请号：US18659338

申请日：2024-05-09

申请人： Acerta Pharma B.V.

发明人： Paul Allen BETHEL ,  Lai Chun CHAN ,  Katie Grace COOPER ,  Robert John COX ,  Michael David GOLDEN ,  Shaun Alan HUGHES ,  Lucinda Victoria JACKSON ,  Kirsty Jane MILLARD ,  Andrew John PHILLIPS ,  Alexander James TELFORD ,  Jerry EVARTS ,  Michael Joseph LAWLER ,  Remy E. J. N. LITJENS ,  Peter Johannes Servaas Savio VAN EIJK ,  Mathilda Maria Henrica VERSTAPPEN ,  Frank L. M. VOS ,  Eric Jurriën ZIJP ,  Qiu JUNYING ,  Rustam Ferdinand GARREY ,  David Allen SHORT ,  Angang WANG

IPC分类号： C07D487/04 ,  C07B63/00

CPC分类号： C07D487/04 ,  C07B63/00 ,  C07B2200/13

摘要： The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

公开(公告)号：US20240166574A1

公开(公告)日：2024-05-23

申请号：US18272304

申请日：2022-01-14

申请人： Asahi Kasei Kabushiki Kaisha

发明人： Takahiro Osaki ,  Yuji Katayama ,  Ryoichi Takada ,  Keitaro Suzumura

IPC分类号： C07B63/00 ,  B01D61/00

CPC分类号： C07B63/00 ,  B01D61/0022 ,  B01D61/005 ,  B01D2311/2643

摘要： Provided is a method for processing a feed solution, which is an organic solution containing a small amount of water, using forward osmosis under a non-heated condition to obtain a dehydrated feed solution without causing degradation or change in quality of a solute. This method is for dehydrating a feed solution containing a first organic solvent, water, and a first solute, and comprises a dehydration step for bring the feed solution and an organic draw solution containing a second organic solvent into contact with each other through a forward osmosis membrane to obtain a dehydrated feed solution that has the moisture content thereof reduced to less than 1 mass % through dehydration. In one mode, the initial moisture content of the feed solution in the dehydration step is not less than 1 mass % but less than 30 mass %, and the initial moisture content of the organic draw solution is less than the initial moisture content of the feed solution.

公开(公告)号：US20240122228A1

公开(公告)日：2024-04-18

申请号：US18303334

申请日：2023-04-19

申请人： MARKHAM BIOTECH INC.

发明人： John Emilio Lopez

IPC分类号： A24B15/167 ,  A61K31/00 ,  A61K31/05

CPC分类号： A24B15/167 ,  A61K31/00 ,  A61K31/05 ,  C07B63/00

摘要： The disclosure provides methods, formulations, and apparatus for making and using cannabinoid formulations.

公开(公告)号：US20230390709A1

公开(公告)日：2023-12-07

申请号：US18237327

申请日：2023-08-23

申请人： ENTEGRIS, INC.

发明人： Kwok-Shun CHENG ,  Rajni PATEL ,  Maybelle WOO ,  Puth PROEUNG

IPC分类号： B01D71/26 ,  B01D69/02 ,  B01D67/00 ,  C07B63/00

CPC分类号： B01D71/26 ,  B01D69/02 ,  B01D67/002 ,  C07B63/00 ,  B01D63/14

摘要： Described are liquid-flowable, porous polyethylene filter membranes that include two opposing sides and that have an asymmetric pore structure; filter components and filters that include this type of porous polyethylene filter membrane; methods of making the porous polyethylene filter membranes, filter components, and filters; and methods of using a porous polyethylene filter membrane, filter component, or filter, to filter a fluid such as a liquid chemical to remove unwanted material from the fluid.

公开(公告)号：US20190241537A1

公开(公告)日：2019-08-08

申请号：US16267383

申请日：2019-02-04

申请人： Seth Dramen

发明人： Seth Dramen

IPC分类号： C07D311/80 ,  B01D3/38 ,  B01D3/40 ,  C07B63/00

CPC分类号： C07D311/80 ,  B01D3/38 ,  B01D3/40 ,  C07B63/00

摘要： Cannabis plant products, and processes for their preparation using hydrodistillation and steam distillation, are described, where such products are measurably or detectably free from terpenes, and thereby odorless, but where they substantially contain the same cannabinoid profile and content, and have the same visual and tactile quality as the original cannabis plant material from which they are obtained.

公开(公告)号：US10005969B2

公开(公告)日：2018-06-26

申请号：US15606181

申请日：2017-05-26

申请人： KOREA INSTITUTE OF ENERGY RESEARCH

发明人： Dong-Woo Cho ,  Jong-Nam Kim ,  Su Jin Jeong ,  Hee Tae Beum ,  Taesung Jung ,  Hyung Chul Yoon ,  Kanghee Cho ,  Sang-Sup Han

IPC分类号： C10G29/22 ,  C07C49/185 ,  C07B63/00 ,  B04B5/00 ,  C07F3/04 ,  G01N21/75

CPC分类号： C10G29/22 ,  B04B5/00 ,  C07B63/00 ,  C07B63/02 ,  C07C49/185 ,  C07F3/04 ,  C10G21/16 ,  C10G2300/201 ,  G01N21/75

摘要： Disclosed is a method of removing calcium from a hydrocarbon fraction using an extraction agent including 2-oxopropanal or derivatives thereof, the method including (S1) adding a hydrocarbon fraction with an extraction agent including 2-oxopropanal or derivatives thereof to give a mixture, (S2) converting an oil-soluble calcium compound into a water-soluble calcium compound by reacting the hydrocarbon fraction with the 2-oxopropanal or derivatives thereof, and (S3) removing the water-soluble calcium compound.

公开(公告)号：US20180105489A1

公开(公告)日：2018-04-19

申请号：US15840691

申请日：2017-12-13

申请人： Asahi Kasei Kabushiki Kaisha

发明人： Masaaki Shinohata ,  Nobuhisa Miyake

IPC分类号： C07C263/20 ,  B01D3/00 ,  B01D3/34 ,  B01D3/14 ,  C07C263/04 ,  C07B63/00 ,  C07C265/14

CPC分类号： C07C263/20 ,  B01D3/009 ,  B01D3/143 ,  B01D3/34 ,  C07B63/00 ,  C07C263/04 ,  Y02P20/127 ,  C07C265/14

摘要： Disclosed is a method for separating, with a multi-stage distillation column, a mixture containing an active hydrogen-containing compound (A) and a compound (B) that reversibly reacts with the active hydrogen containing compound (A), the method comprising distillation-separating the active hydrogen-containing compound (A) and the compound (B) with the multi-stage distillation column in the presence of an intermediate-boiling-point inactive compound (C) that has a normal boiling point between a normal boiling point of the active hydrogen-containing compound (A) and a normal boiling point of the compound (B) and is chemically inactive for both of the (A) and the compound (B).

公开(公告)号：US20180093961A1

公开(公告)日：2018-04-05

申请号：US15564590

申请日：2016-04-13

申请人： E I Du Pont DE NEMOURS and Company ,  Archer Daniels Midland Company

发明人： Stephen J. Howard ,  Kristina A. Kreutzer ,  Bhuma Rajagopalan ,  Eric R. Sacia ,  Alexandra Sanborn ,  Brennan Smith

IPC分类号： C07D307/68 ,  C07B33/00 ,  C07B63/00 ,  B01J21/06 ,  B01J23/10 ,  B01J23/656 ,  B01J23/75 ,  C08G69/28 ,  C08G69/32 ,  C08L77/10

CPC分类号： C07D307/68 ,  B01J21/066 ,  B01J23/10 ,  B01J23/6562 ,  B01J23/75 ,  B01J31/04 ,  B01J2231/70 ,  C07B33/00 ,  C07B63/00 ,  C08G63/181 ,  C08G69/28 ,  C08G69/32 ,  C08L77/10 ,  Y02P20/125

摘要： An integrated process is described for producing 2,5-furandicarboxylic acid and/or a derivative thereof from a six carbon sugar-containing feed, comprising: a) dehydrating a feed comprising a six-carbon sugar unit, in the presence of a bromine source and of a solvent, to generate an oxidation feed comprised of at least one of 5-hydroxymethylfurfural and/or a derivative or derivatives of 5-hydroxymethylfurfural in the solvent, together with at least one bromine containing species; b) contacting the oxidation feed from step (a) with a metal catalyst and with an oxygen source under oxidation conditions to produce an oxidation product mixture comprising 2,5-furandicarboxylic acid (FDCA) and/or a derivative thereof, the solvent, and a residual catalyst; c) purifying and separating the mixture obtained in step (b) to obtain FDCA and/or a derivative thereof and the solvent; and d) recycling at least a portion of the solvent obtained in step (c) to step (a).

公开(公告)号：US20180044194A1

公开(公告)日：2018-02-15

申请号：US15789997

申请日：2017-10-21

申请人： XIANGTAN UNIVERSITY

发明人： Lixin YANG ,  Mi FU ,  Yi WANG ,  Hongyu QI ,  Yu XU ,  Yali LIU ,  Yalin GUI ,  Jing HE

IPC分类号： C01D15/08 ,  B01D12/00 ,  B01D11/04 ,  C07F9/11

CPC分类号： C01D15/08 ,  B01D11/04 ,  B01D12/00 ,  C01F5/22 ,  C01F5/24 ,  C07B63/00 ,  C07F9/11

摘要： The present invention discloses a method for producing lithium carbonate from a low-lithium brine by separating magnesium and enriching lithium. A salt-lake brine is used as a raw material and is converted into halide salts through dehydration by evaporation and separation by crystallization; the halide salts are directly extracted using trialkyl phosphate or a mixture of trialkyl phosphate and monohydric alcohol, and an organic extraction phase as well as remaining halide salts are obtained after solid-liquid separation; reverse extraction is performed on the organic extraction phase to obtain a lithium-rich solution with a low magnesium-to-lithium ratio, and lithium carbonate is obtained after concentration and removal of magnesium by alkalization. The used solid-liquid extraction method is simple with no co-extraction agent used, and a solute distribution driving force is strong, unaffected by phase equilibrium of the brine extraction agent. The mass ratio of magnesium-to-lithium significantly decreases in the extraction phase.

公开(公告)号：US20180028695A1

公开(公告)日：2018-02-01

申请号：US15219745

申请日：2016-07-26

申请人： LABORATOIRES CYCLOPHARMA

发明人： Gilles VIOT

IPC分类号： A61K51/04 ,  C07J1/00

CPC分类号： A61K51/0493 ,  C07B59/007 ,  C07B63/00 ,  C07B2200/05 ,  C07J1/007 ,  C07J71/0089

摘要： The present invention relates to a method for the synthesis of a radioactive agent composition comprising at least a purification step carried out in the presence of an antioxidant, to the composition obtained by this method comprising radioactive agent and excipient, and to the method for preventing radiolysis of radioactive agent composition comprising the synthesis of said radioactive agent according to the method of the invention.