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公开(公告)号：US11925907B2
公开(公告)日：2024-03-12
申请号：US17628853
申请日：2020-07-21
发明人： Christopher Adair , Ben Geiling
IPC分类号： B01J19/18 , A61K31/05 , A61K31/352 , A61K36/185 , B01D9/00 , B01D11/02 , B01J4/00 , B01J19/00 , C07B63/00
CPC分类号： B01D9/0036 , A61K31/05 , A61K31/352 , A61K36/185 , B01D9/0063 , B01D11/0203 , B01D11/0288 , B01J4/001 , B01J19/0066 , B01J19/18 , C07B63/00 , B01D9/0009 , B01D9/0018 , C07B2200/13
摘要： Disclosed herein is a method for continuously preparing crystalline cannabinoid particles. The method includes preparing a cannabinoid-rich solution that comprises a first cannabinoid and inducing the cannabinoid-rich solution to a supersaturated state in which the first cannabinoid has a supersaturated concentration that is greater than a corresponding saturation concentration of the first cannabinoid. The method includes flowing the cannabinoid-rich solution into a continuous stirred-tank reactor (CSTR) in a continuous manner, mixing the cannabinoid-rich solution under turbulent mixing conditions to form a plurality of crystalline cannabinoid particles and a cannabinoid-depleted solution within the CSTR, and discharging the plurality of crystalline cannabinoid particles and the cannabinoid-depleted solution from the CSTR in a continuous manner to provide a flow rate through the CSTR. The method includes separating crystalline cannabinoid particles from the plurality of crystalline cannabinoid particles and the cannabinoid-depleted solution in a continuous manner.
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公开(公告)号：US20230159364A1
公开(公告)日：2023-05-25
申请号：US16964598
申请日：2020-06-26
CPC分类号： C02F9/00 , B01D9/005 , B01D9/0009 , B01D9/0013 , C02F2103/08
摘要： A novel Salt Repellent Technique is presented to remove all inorganic salts from seawater to get potable water. The repellent additives recommended throws out all salts of sodium, magnesium, calcium, potassium and the like ions from seawater and paves way to get salt free potable water. The conventional washing of ice crystals is completely avoided due to the presence of additives. This technique helps to remove last traces of salts from seawater and analogous waters, without undertaking the conventional washing process. The new salt repellent process assures of high water recovery, ease of operation, lesser pollution, smaller plants, simpler machinery and technology, lower energy cost, nil or lesser pre-treatment and recovery of valuable by-products. To reduce the TDS still lower, it is recommended to have a simplified reverse osmosis unit in addition, as a post-operative arrangement.
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公开(公告)号：US20180050280A1
公开(公告)日：2018-02-22
申请号：US15238320
申请日：2016-08-16
申请人： Naveed Aslam
发明人： Naveed Aslam
CPC分类号： B01D9/0009 , B01D9/0063 , B01D2009/0086 , C02F1/22 , C02F1/5236 , C02F1/68 , C02F2001/5218 , C02F2103/10 , C02F2209/02 , C02F2305/00
摘要： A method and crystallizer for treating produced water through the steps of feeding produced water to a porous pipe in a chamber wherein the chamber is cylindrically shaped having an interior wall with a top and a bottom; feeding gaseous nitrogen to a nozzle present in the chamber, which is in fluid communication with an interior pipe; feeding the produced water to the interior pipe wherein slush is formed in the pipe and this slush is forced through the interior pipe to the top of the chamber; operating at least one scraper which is mounted circumferentially about the porous pipe and having arms that extend outwardly from the scraper center in contact with the interior wall of the chamber wherein the scraper will remove salt crystals from the interior walls of the chamber; recovering salt crystals from the bottom of the chamber; and recovering fresh water from the chamber.
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4.发明申请公开(公告)号：US20180037527A1
公开(公告)日：2018-02-08
申请号：US15784913
申请日：2017-10-16
CPC分类号： C07C29/76 , B01D1/30 , B01D5/0036 , B01D9/0009 , B01D9/0054 , B01D9/0059 , B01D9/0063 , B01D2257/204 , C07C31/202
摘要： A MEG reclamation process includes the step of increasing above 2,000 ppm the divalent metal salts concentration of a rich (wet) MEG feed stream flowing into a precipitator. The increasing step includes routing a salts-saturated MEG slipstream from the flash separator it to the precipitator. The slipstream may be mixed with a fresh water feed stream, a portion of the rich MEG feed stream, or some combination of the two. The rich MEG feed stream also may be split into two streams, with a portion of the stream being heated and routed to the flash separator and the other portion being combined as above with the removed slipstream. The process can be performed on the slipstream after dilution and prior to entering the precipitator or after being loaded into the precipitator. Removal of the insoluble salts may be done in either a batch or continuous mode.
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公开(公告)号：US20160228373A1
公开(公告)日：2016-08-11
申请号：US15022429
申请日：2014-09-16
发明人： Iris Duarte , Maria Jose Pereira , Luis Padrela , Marcio Temtem
IPC分类号： A61K9/16 , A61K31/194 , C30B29/54 , A61K31/55 , A61K31/455 , C30B11/02 , A61K31/522 , A61K31/60
CPC分类号： A61K9/1688 , A61K9/1617 , A61K31/194 , A61K31/455 , A61K31/522 , A61K31/55 , A61K31/60 , B01D9/0009 , B01D9/0063 , C30B11/02 , C30B29/54
摘要： The present invention discloses a scalable and solvent-free method to produce cocrystals in a particulate form. A method of making cocrystals comprises the steps of: a) feeding a molten mixture of at least a first substance and a second substance which are able to form cocrystals to an atomizer; b) atomizing the molten mixture to droplets; c) solidifying the droplets to particles; d) collecting the said particles. The invention also provides the use of cocrystals made according to the method of the invention in the formulation of a pharmaceutical composition. The invention also provides cocrystals obtainable or obtained by the method of the present invention, in particular cocrystals in the form of particles. Also provided is a pharmaceutical composition comprising cocrystals made according to the method of the invention, in particular, a pharmaceutical composition comprising cocrystals in the form of particles made according to the method of the invention.
摘要翻译： 本发明公开了一种可扩展且无溶剂的方法来生产颗粒形式的共晶体。 制备共晶体的方法包括以下步骤：a）将能够形成共晶体的至少第一物质和第二物质的熔融混合物送入雾化器; b）将熔融混合物雾化成液滴; c）将液滴固化成颗粒; d）收集所述颗粒。 本发明还提供根据本发明的方法制备的共晶在药物组合物的制剂中的用途。 本发明还提供了可通过本发明的方法获得或获得的共晶体，特别是颗粒形式的共晶体。 还提供了包含根据本发明的方法制备的共晶体的药物组合物，特别是包含根据本发明方法制备的颗粒形式的晶体的药物组合物。
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公开(公告)号：US20140223958A1
公开(公告)日：2014-08-14
申请号：US14347228
申请日：2012-09-26
IPC分类号： C02F1/22
CPC分类号： C02F1/22 , B01D9/0009 , B01D9/0081 , B01D9/04 , C02F1/265 , C02F1/36 , C02F2103/08 , Y02A20/132
摘要： A freeze desalination process uses cyclopentane (“C5H10”) (14) as an agent for the formation of a gas hydrate as a clathrate (13). A crystallizer vessel (10) containing a mixture of seawater (11) and diffuse bubbles (18) of C5H10 is cooled to allow a gas hydrate phase to form. An ultrasonic transducer (21) located in the bubble stream encourages nucleation and thus clathrate formation.
摘要翻译： 冷冻脱盐方法使用环戊烷（“C5H10”）（14）作为形成气态水合物作为包合物的试剂（13）。 将包含海水（11）和C5H10的扩散气泡（18）的混合物的结晶器容器（10）冷却以形成气体水合物相。 位于气泡流中的超声换能器（21）促进成核，从而形成包合物。
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公开(公告)号：US08431084B2
公开(公告)日：2013-04-30
申请号：US12821186
申请日：2010-06-23
申请人： Stephen W. Fetsko
发明人： Stephen W. Fetsko
IPC分类号： B01D9/02
CPC分类号： C07C37/84 , B01D9/0009 , C07C39/16
摘要： A crystallizer for the evaporative production of phenol-BPA adduct crystals is provided that achieves more uniform crystal growth while suppressing undesired crystal nucleation. The crystallizer includes a cylindrical vessel; a draft tube concentrically disposed within the cylindrical vessel such that an annular space is defined between the vessel and tube; an impeller that circulates liquid in the vessel through the draft tube and the annular space, and a plurality of nozzles mounted around an inner wall of said cylindrical vessel that introduce an evaporative coolant into the vessel. Each of the nozzles includes a discharge end disposed between about 30% and 60% of a radial extent of the annular space, and is located below an upper end of the draft tube a distance of between about 50% to 150% of the diameter of the vessel. Such a nozzle arrangement provides a consistent and uniform concentration of coolant across the surface of the boiling zone that prevents or at least reduces unwanted crystal nucleation.
摘要翻译： 提供了用于蒸发生产苯酚 - BPA加合物晶体的结晶器，其在抑制不期望的晶体成核的同时实现更均匀的晶体生长。 结晶器包括圆柱形容器; 同心地设置在圆柱形容器内的引流管，使得在容器和管之间限定环形空间; 叶轮，其通过所述引流管和所述环形空间使所述容器中的液体循环;以及多个喷嘴，所述喷嘴安装在所述圆柱形容器的内壁周围，所述喷嘴将蒸发的冷却剂引入所述容器。 每个喷嘴包括设置在环形空间的径向范围的约30％至60％之间的排放端，并且位于引流管的上端下方的距离在距离的大约50％至150％ 船只。 这样的喷嘴装置提供了在沸腾区域的表面上的一致且均匀的冷却剂浓度，其防止或至少减少了不想要的晶体成核。
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公开(公告)号：US20120142974A9
公开(公告)日：2012-06-07
申请号：US12821186
申请日：2010-06-23
申请人： Stephen W. Fetsko
发明人： Stephen W. Fetsko
CPC分类号： C07C37/84 , B01D9/0009 , C07C39/16
摘要： Both a crystallizer and method for the evaporative production of phenol-BPA adduct crystals are provided that achieve more uniform crystal growth while suppressing undesired crystal nucleation. The crystallizer includes a cylindrical vessel; a draft tube concentrically disposed within the cylindrical vessel such that an annular space is defined between the vessel and tube; an impeller that circulates liquid in the vessel through the draft tube and the annular space, and a plurality of nozzles mounted around an inner wall of said cylindrical vessel that introduce an evaporative coolant into the vessel. Each of the nozzles includes a discharge end disposed between about 30% and 60% of a radial extent of the annular space, and is located below an upper end of the draft tube a distance of between about 50% to 150% of the diameter of the vessel. Such a nozzle arrangement provides a consistent and uniform concentration of coolant across the surface of the boiling zone that prevents or at least reduces unwanted crystal nucleation on the inner surfaces of the vessel and promotes uniform crystal growth by providing a consistent and uniform degree of supersaturation across the annular space within the boiling zone.
摘要翻译： 提供了一种用于蒸发生产苯酚 - BPA加合物晶体的结晶器和方法，其在抑制不需要的晶体成核的同时实现更均匀的晶体生长。 结晶器包括圆柱形容器; 同心地设置在圆柱形容器内的引流管，使得在容器和管之间限定环形空间; 叶轮，其通过所述引流管和所述环形空间使所述容器中的液体循环;以及多个喷嘴，所述喷嘴安装在所述圆柱形容器的内壁周围，所述喷嘴将蒸发的冷却剂引入所述容器。 每个喷嘴包括设置在环形空间的径向范围的约30％至60％之间的排放端，并且位于引流管的上端下方的距离在距离的大约50％至150％ 船只。 这种喷嘴装置提供了在沸腾区域的表面上的一致且均匀的冷却剂浓度，其防止或至少减少了容器内表面上的不期望的晶体成核，并通过提供一致且均匀的过饱和度来促进均匀的晶体生长 沸腾区内的环形空间。
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公开(公告)号：US06383233B1
公开(公告)日：2002-05-07
申请号：US09142501
申请日：1999-01-19
申请人： Karl Reuter
发明人： Karl Reuter
IPC分类号： B01D900
CPC分类号： B01D9/0009 , B01D9/0036 , B01D9/005
摘要： A process is described for separating a desired substance from an aggregate mixture in which process a three-phase dispersion is formed, the first phase comprising droplets phase comprising a liquid transport phase, and the third phase comprising a surface upon which the desired substance can crystallize, whereby a chemical potential exists for crystal growth of the desired substance in the third phase thereby creating a flow of the desired substance from the first phase through the second phase to the third phase where the desired substance crystallizes, characterized in that the Gibb's free enthalpy of formation (&Dgr;G) of the droplets is
摘要翻译： 描述了一种将所需物质与聚集混合物分离的方法，其中形成三相分散体的过程中，第一相包含液相，其包含液体输送相，第三相包含所需物质可结晶的表面 ，由此存在第三相中所需物质的晶体生长的化学势，从而产生所需物质从所述第一相到第二相到期望物质结晶的第三相的流动，其特征在于，Gibb的游离焓 （DELTAG）小于0。
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公开(公告)号：US6072066A
公开(公告)日：2000-06-06
申请号：US51598
申请日：1998-05-04
申请人： Alain Tirtiaux , Chee Hong Tan
发明人： Alain Tirtiaux , Chee Hong Tan
CPC分类号： B01D9/0009 , C11B15/00 , C11B7/0091
摘要： Process for crystallizing fatty substances for their subsequent fractionation especially by pressure filtering, consisting in particular in melting the fatty substances, dividing the molten mass into beads, feeding these beads into a pre-refrigerated aqueous solution, adjusting the concentration of the fatty substance relative to the aqueous solution, adjusting the feed rate of said beads, adjusting the temperature of the beads/solution mixture, maintaining said mixture temperature until the crystallization of each bead has completely stabilized, subsequently transferring the beads/solution mixture to the filtration location, separating the fatty substance beads under a low pressure from the aqueous solution, and finally extracting from said fatty substance beads, under high pressure, the liquid portion of the fatty substance, and apparatus for applying this process.
摘要翻译： PCT No.PCT / BE96 / 00106 Sec。 371日期：1998年4月14日 102（e）1998年4月14日PCT PCT 1996年10月4日PCT公布。 出版物WO97 / 14777 日期1997年04月24日特别是通过压滤法结晶脂肪物质以进行后续分馏的方法，特别是在熔化脂肪物质时，将熔融物质分成珠，将这些珠子送入预冷的水溶液中，调节浓度 相对于水溶液的脂肪物质，调节所述珠粒的进料速率，调节珠子/溶液混合物的温度，保持所述混合物温度直到每个珠粒的结晶完全稳定，随后将珠/溶液混合物转移到 过滤位置，在低压下从水溶液中分离脂肪物质珠，最后在高压下从所述脂肪物质珠提取脂肪物质的液体部分，以及用于施加该过程的装置。
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