公开(公告)号：US20160228373A1

公开(公告)日：2016-08-11

申请号：US15022429

申请日：2014-09-16

申请人： HOVIONE INTERNATIONAL LTD

发明人： Iris Duarte ,  Maria Jose Pereira ,  Luis Padrela ,  Marcio Temtem

IPC分类号： A61K9/16 ,  A61K31/194 ,  C30B29/54 ,  A61K31/55 ,  A61K31/455 ,  C30B11/02 ,  A61K31/522 ,  A61K31/60

CPC分类号： A61K9/1688 ,  A61K9/1617 ,  A61K31/194 ,  A61K31/455 ,  A61K31/522 ,  A61K31/55 ,  A61K31/60 ,  B01D9/0009 ,  B01D9/0063 ,  C30B11/02 ,  C30B29/54

摘要： The present invention discloses a scalable and solvent-free method to produce cocrystals in a particulate form. A method of making cocrystals comprises the steps of: a) feeding a molten mixture of at least a first substance and a second substance which are able to form cocrystals to an atomizer; b) atomizing the molten mixture to droplets; c) solidifying the droplets to particles; d) collecting the said particles. The invention also provides the use of cocrystals made according to the method of the invention in the formulation of a pharmaceutical composition. The invention also provides cocrystals obtainable or obtained by the method of the present invention, in particular cocrystals in the form of particles. Also provided is a pharmaceutical composition comprising cocrystals made according to the method of the invention, in particular, a pharmaceutical composition comprising cocrystals in the form of particles made according to the method of the invention.

摘要翻译： 本发明公开了一种可扩展且无溶剂的方法来生产颗粒形式的共晶体。 制备共晶体的方法包括以下步骤：a）将能够形成共晶体的至少第一物质和第二物质的熔融混合物送入雾化器; b）将熔融混合物雾化成液滴; c）将液滴固化成颗粒; d）收集所述颗粒。 本发明还提供根据本发明的方法制备的共晶在药物组合物的制剂中的用途。 本发明还提供了可通过本发明的方法获得或获得的共晶体，特别是颗粒形式的共晶体。 还提供了包含根据本发明的方法制备的共晶体的药物组合物，特别是包含根据本发明方法制备的颗粒形式的晶体的药物组合物。