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公开(公告)号：US20230298167A1
公开(公告)日：2023-09-21
申请号：US18009138
申请日：2021-06-07
Inventor： Sudipta SAMANTA , Muthukaruppan SWAMINATHAN , Jianing HU , Chan Soh HA , Shen-Yi Lan CHEONG
IPC: G06T7/00 , G06N3/043 , G06N5/048 , G06N3/0464
CPC classification number: G06T7/0012 , G06N3/043 , G06N5/048 , G06N3/0464
Abstract: The present invention relates to the provision of an automated system and a computer-implemented method for detecting a disease such as nasopharyngeal cancer (NPC) based upon the use of either a Fuzzy Inference (FI) system or a deep learning-fuzzy inference (DeLFI) hybrid model to analyse immunofluorescence assay (IFA) images. For NPC detection, the system and method of the invention would distinguish between Epstein Barr Virus (EBV) Early Antigen (EA) positive and negative cells, and identify cellular patterns which are indicative of NPC. The DeLFI hybrid model requires less human evaluation and thereby has the potential to improve the scalability and accuracy of NPC detection.
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公开(公告)号：US20210108246A1
公开(公告)日：2021-04-15
申请号：US17077581
申请日：2020-10-22
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Rongji SUM , Muthukaruppan SWAMINATHAN , Ian CHEONG
Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.
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公开(公告)号：US20200377898A1
公开(公告)日：2020-12-03
申请号：US16070648
申请日：2017-02-02
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Lianghui JI , Yanbin LIU , Chong Mei John KOH , Sihui Amy YAP
Abstract: The present invention relates to the field of molecular biology and more particularly to promoters useful for metabolic engineering in yeast or fungi for the production of biobased chemicals with broad applications. Intron-containing promoters with strong activity during oil-accumulation stages are particularly useful for genetic engineering in yeast and fungi, particularly Rhodosporidium or Rhodotorula genera. Such promoter are capable of driving strong expression of RNA or proteins in species of the Rhodosporidium or Rhodotorula genera.
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公开(公告)号：US10570402B2
公开(公告)日：2020-02-25
申请号：US16190386
申请日：2018-11-14
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Lin Cai , Longhua Sun , Lin Fu , Lianghui Ji
Abstract: The present invention relates to the field of the production of transgenic plants through Agrobacterium-mediated transformation of cells of somatic embryogenic calli or embryogenic suspension cultures and regeneration of the transformed cells into fruit-setting plants. In particular, the present invention relates to the production of transgenic plants in the Euphorbiaceae family. The present invention further relates to media compositions, selection methods and engineered Agrobacterium tumefaciens strains that improve Agrobacterium-mediated transformation efficiency.
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公开(公告)号：US10325183B2
公开(公告)日：2019-06-18
申请号：US15511089
申请日：2015-09-15
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Muthukaruppan Swaminathan , Tobias Sjoblom , Ian Cheong , Obdulio Piloto
Abstract: An improved system and method for digital image classification is provided. A host computer having a processor is coupled to a memory storing thereon reference feature data. A graphics processing unit (GPU) having a processor is coupled to the host computer and is configured to obtain, from the host computer, feature data corresponding to the digital image; to access, from the memory, the one or more reference feature data; and to determine a semi-metric distance based on a Poisson-Binomial distribution between the feature data and the one or more reference feature data. The host computer is configured to classify the digital image using the determined semi-metric distance.
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Patent Agency Ranking
公开(公告)号：US10081821B2
公开(公告)日：2018-09-25
申请号：US15326077
申请日：2015-08-21
Applicant: Temasek Life Sciences Laboratory Limited
Inventor： Yanbin Liu , Chong Mei Koh , Lianghui Ji
IPC: C12N1/14 , C12N1/15 , C12N9/02 , C12P7/64 , C12N15/52 , C12N15/81 , C12N9/04 , C12N9/10 , C12N9/88 , C12N9/90 , C12N9/00
Abstract: The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of polyunsaturated fatty acids (PUFA) in fungal hosts selected from Rhodosporidium and Rhodotorula genera. The present invention further relates to a modified fungal host cell having reduced native aldehyde dehydrogenase (ALD 1) enzyme activity, and methods for producing omega-3 and omega-6 fatty acids and triacylglycerides, by growing said fungal host cell under suitable conditions.
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27.发明申请公开(公告)号：US20170362285A1
公开(公告)日：2017-12-21
申请号：US15535466
申请日：2015-12-14
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Yanbin LIU , Chong Mei KOH , Lianghui JI
CPC classification number: C07K14/37 , C12N9/0008 , C12N15/113 , C12N15/80 , C12P21/02 , C12P23/00
Abstract: The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of carotenoids in fungal hosts selected from Rhodospordium and Rhodotorula genera.
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公开(公告)号：US20170000877A1
公开(公告)日：2017-01-05
申请号：US15107074
申请日：2014-12-12
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Fang HE , Hwei-Sing Jimmy KWANG , Prabakaran MOOKKAN
IPC: A61K39/145 , C12N7/00 , C07K14/005
CPC classification number: A61K39/145 , A61K39/12 , A61K2039/5252 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16171
Abstract: The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine strain using hemagglutinin (HA) engineering to elicit cross-clade protection. The present invention also relates to an epitope-chimeric H5 and to a reverse genetics (RG) influenza virus expressing the epitope-chimeric H5.
Abstract translation: 本发明涉及一价H5N1疫苗。 更具体地说，本发明涉及使用血凝素（HA）工程开发一价H5疫苗株以引发交叉枝叶保护。 本发明还涉及表位嵌合H5和表达表位嵌合H5的反向遗传学（RG）流感病毒。
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公开(公告)号：US12158426B2
公开(公告)日：2024-12-03
申请号：US17999331
申请日：2021-05-20
Inventor： In-Cheol Jang , Benny Jian Rong Sng , Gajendra Pratap Singh , Rajeev J. Ram
Abstract: The present invention relates to the use of a Raman spectral signature for detection of plant metabolites, specifically carotenoids, in tissue of a plant leaf. Carotenoids are used as a biomarker for an early, real-time diagnosis of shade avoidance syndrome (SAS) in growing plants in a non-invasive or non-destructive way in order to detect the adverse effect of the SAS upon their health, and ultimately their yield. The early, real-time diagnosis of SAS provides a window period within which further adverse effects of SAS may be slowed or prevented without negatively affecting the yield of growing plants or leafy vegetables.
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公开(公告)号：US11034981B2
公开(公告)日：2021-06-15
申请号：US16484322
申请日：2018-01-29
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Lianghui Ji , Yanbin Liu , Chong Mei John Koh , Sihui Amy Yap , Si Te Ngoh
IPC: C12P7/04
Abstract: The present invention relates to the field of fungal production fatty alcohols. More specifically, the present invention relates to genetically modified host cells, nucleic acid constructs and culture medium for the production of fatty alcohols in Rhodosporidium.
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