公开(公告)号：US20170362285A1

公开(公告)日：2017-12-21

申请号：US15535466

申请日：2015-12-14

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED

Inventor： Yanbin LIU ,  Chong Mei KOH ,  Lianghui JI

IPC: C07K14/37 ,  C12N9/02 ,  C12N15/80 ,  C12N15/113 ,  C12P23/00 ,  C12P21/02

CPC classification number: C07K14/37 ,  C12N9/0008 ,  C12N15/113 ,  C12N15/80 ,  C12P21/02 ,  C12P23/00

Abstract: The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of carotenoids in fungal hosts selected from Rhodospordium and Rhodotorula genera.

公开(公告)号：US20170198315A1

公开(公告)日：2017-07-13

申请号：US15326077

申请日：2015-08-21

Applicant: Temasek Life Sciences Laboratory Limited

Inventor： Yanbin LIU ,  Chong Mei KOH ,  Lianghui JI

IPC: C12P7/64 ,  C12N15/52 ,  C12N9/10 ,  C12N9/88 ,  C12N9/00 ,  C12N9/04 ,  C12N9/02 ,  C12N9/90

CPC classification number: C12P7/6427 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/0071 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12N15/52 ,  C12N15/81 ,  C12P7/6463 ,  C12Y101/0104 ,  C12Y102/01003 ,  C12Y102/01012 ,  C12Y114/19 ,  C12Y114/19001 ,  C12Y114/19003 ,  C12Y114/19006 ,  C12Y203/0102 ,  C12Y203/03008 ,  C12Y401/01001 ,  C12Y402/01011 ,  C12Y502/01008 ,  C12Y602/01003 ,  C12Y604/01002

Abstract: The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of polyunsaturated fatty acids (PUFA) in fungal hosts selected from Rhodosporidium and Rhodotorula genera. The present invention further relates to a modified fungal host cell having reduced native aldehyde dehydrogenase (ALD 1) enzyme activity, and methods for producing omega-3 and omega-6 fatty acids and triacylglycerides, by growing said fungal host cell under suitable conditions.