公开(公告)号：US20170000877A1

公开(公告)日：2017-01-05

申请号：US15107074

申请日：2014-12-12

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED

Inventor： Fang HE ,  Hwei-Sing Jimmy KWANG ,  Prabakaran MOOKKAN

IPC: A61K39/145 ,  C12N7/00 ,  C07K14/005

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5252 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16171

Abstract: The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine strain using hemagglutinin (HA) engineering to elicit cross-clade protection. The present invention also relates to an epitope-chimeric H5 and to a reverse genetics (RG) influenza virus expressing the epitope-chimeric H5.

Abstract translation: 本发明涉及一价H5N1疫苗。 更具体地说，本发明涉及使用血凝素（HA）工程开发一价H5疫苗株以引发交叉枝叶保护。 本发明还涉及表位嵌合H5和表达表位嵌合H5的反向遗传学（RG）流感病毒。

公开(公告)号：US20130251715A1

公开(公告)日：2013-09-26

申请号：US13897725

申请日：2013-05-20

Applicant: NATIONAL INSTITUTE OF HEALTH RESEARCH AND DEVELOPMENT (NIHRD)-MINISTRY OF HEALTH ,  Temasek Life Sciences Laboratory Limited

Inventor： Hong Liang QIAN ,  Fang HE ,  Siti Fadilah SUPARI ,  Hwei-Sing KWANG

IPC: C07K16/10

CPC classification number: C07K16/1018 ,  A61K39/42 ,  C07K2317/24 ,  C07K2317/76 ,  C12N2760/16111 ,  G01N33/56983 ,  G01N2333/11

Abstract: Monoclonal antibodies and related binding proteins that are specific for conformational epitopes of avian influenza virus H5 subtype hemagglutinin glycoprotein are provided. The antibodies can be used for the detection and treatment of H5 subtype AIV in specimens.

Abstract translation: 提供了特异于禽流感病毒H5亚型血凝素糖蛋白构象表位的单克隆抗体和相关结合蛋白。 该抗体可用于标本中H5亚型AIV的检测和治疗。