公开(公告)号：US20240335398A1

公开(公告)日：2024-10-10

申请号：US18679670

申请日：2024-05-31

申请人： JANSSEN PHARMACEUTICALS, INC.

发明人： M. Ilias JIMIDAR ,  Jingli WANG ,  Caroline AERTS ,  Katrien VERBRUGGEN ,  Saartje THEUNIS ,  Jaskaran SINGH ,  Kris KAYENS ,  Peter ZANNIKOS ,  Hong YAN

IPC分类号： A61K31/135 ,  A61K9/00 ,  A61M11/00 ,  A61P25/24

CPC分类号： A61K31/135 ,  A61K9/0043 ,  A61P25/24 ,  A61M11/001

摘要： The present invention is directed to pharmaceutical products, and to methods for the treatment of depression (e.g., major depressive disorder) and other diseases or disorders for which esketamine has a therapeutic benefit. In some embodiments, the methods are useful for the treatment of treatment-refractory or treatment-resistant depression or suicidal ideation. Methods of intranasal administration and devices for intranasal administration are also disclosed.

公开(公告)号：US12097322B2

公开(公告)日：2024-09-24

申请号：US17118552

申请日：2020-12-10

申请人： BMC MEDICAL CO., LTD.

发明人： Lijun Liu ,  Jianxin Zhi ,  Zhi Zhuang ,  Min Chang

IPC分类号： A61M16/00 ,  A61L9/20 ,  A61M11/00 ,  A61M16/04 ,  A61M16/06 ,  A61M16/08 ,  A61M16/10 ,  A61M16/16 ,  G16H20/40 ,  G16H40/63

CPC分类号： A61M16/0066 ,  A61L9/20 ,  A61M16/1075 ,  A61M16/109 ,  A61M16/16 ,  A61M16/161 ,  G16H20/40 ,  A61L2209/12 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M16/0465 ,  A61M16/06 ,  A61M16/0616 ,  A61M16/0666 ,  A61M16/1055 ,  A61M16/107 ,  A61M2205/3306 ,  A61M2205/3368 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/42 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/587 ,  A61M2209/10 ,  A61M2230/42

摘要： A respiratory ventilation apparatus configured to deliver a respiratory gas to a patient interface is provided. The apparatus may include a gas pressurization unit configured to generate a pressurized respiratory gas, a gas inlet port configured to introduce the respiratory gas into the respiratory ventilation apparatus, a gas outlet port configured to discharge the pressurized respiratory gas to a respiration tube, a detection module configured to detect the pressure of the pressurized respiratory gas, at least one non-volatile memory configured to store a plurality of parameters and a plurality of programs, and one or more controllers. The one or more controllers may be configured to initiate the respiratory ventilation apparatus upon a boot operation, and/or initiate a program that constantly reads information from the detection module, and controls the pressure of the pressurized respiratory gas using the information read from the detection module and at least one parameter.

公开(公告)号：US12083285B2

公开(公告)日：2024-09-10

申请号：US16883677

申请日：2020-05-26

申请人： Stamford Devices Ltd.

发明人： Andrew R. Clark ,  James B. Fink

IPC分类号： A61M16/14 ,  A61M11/00 ,  A61M15/00 ,  A61M16/04 ,  A61M16/06 ,  A61M16/08 ,  A61M39/10

CPC分类号： A61M16/14 ,  A61M11/001 ,  A61M15/009 ,  A61M16/0465 ,  A61M16/0488 ,  A61M16/0666 ,  A61M16/0816 ,  A61M16/0883 ,  A61M11/005 ,  A61M2039/1077 ,  A61M2202/0488 ,  A61M2205/0294 ,  A61M2205/3379 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/8206 ,  A61M2230/40 ,  A61M2240/00

摘要： A method of delivering aerosolized surfactant to an infant that includes interfacing an aerosolization device with an airway of an infant and aerosolizing, using the aerosolization device, a volume of surfactant into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 μm at a rate of at least 0.1 ml/min. The surfactant is aerosolized within about 1 to 8 cm from a patient interface. Aerosol is generated for up to approximately 80% or each inspiration. The method also includes delivering the aerosolized surfactant to the infant's airway.

公开(公告)号：US20240293628A1

公开(公告)日：2024-09-05

申请号：US18658680

申请日：2024-05-08

申请人： DAIKIN INDUSTRIES, LTD.

发明人： Junichiro ARAI ,  Nobuaki TAKEDA ,  Joonsoo CHO

IPC分类号： A61M11/00 ,  A61M11/04

CPC分类号： A61M11/001 ,  A61M11/042 ,  A61M2205/36

摘要： A spray device includes a useful substance having an antioxidative effect or an anti-inflammatory effect, a sprayer configured to spray the useful substance into a space in which a target person is present, and a controller configured to control the sprayer. The useful substance sprayed by the sprayer has a particle diameter of 1 μm to 10 μm. An air treatment device includes the spray device.

公开(公告)号：US20240269398A1

公开(公告)日：2024-08-15

申请号：US18570507

申请日：2022-06-15

申请人： APTAR FRANCE SAS

发明人： Francois LE MANER ,  Ludovic PETIT

IPC分类号： A61M11/00 ,  A61M15/08 ,  A61M39/24

CPC分类号： A61M11/007 ,  A61M15/08 ,  A61M39/24 ,  A61M2039/242

摘要： A spray head (10) for a device for dispensing a fluid product, comprising a body (11) provided with a spray hole (12), the spray head (10) comprising a connecting member (15) rigidly attached to the body (11), the connecting member (15) defining a central axial channel (16), the spray head (10) comprising at least one valve (20; 40) forming precompression means for generating a calibrated spray through the spray hole (12), an intermediate member (14) being inserted between the connecting member (15) and the body (11), the intermediate member (14) being hollow and comprising an opening (14′) that opens into the connecting member (15), a sleeve (40) being mounted so as to slide in the connecting member (15) around the intermediate member (14) between an open position and a closed position, a resilient element (41) biasing the sleeve (14) to its closed position in which it closes off the opening (14′), the sleeve (40) being moved towards its open position when the flow of fluid product (F) is actuated based on a predetermined pressure.

公开(公告)号：US12059526B2

公开(公告)日：2024-08-13

申请号：US18331201

申请日：2023-06-08

申请人： BMC MEDICAL CO., LTD.

发明人： Lijun Liu ,  Jianxin Zhi ,  Zhi Zhuang ,  Min Chang

IPC分类号： A61M16/00 ,  A61L9/20 ,  A61M11/00 ,  A61M16/04 ,  A61M16/06 ,  A61M16/08 ,  A61M16/10 ,  A61M16/16 ,  G16H20/40 ,  G16H40/63

CPC分类号： A61M16/0066 ,  A61L9/20 ,  A61M16/1075 ,  A61M16/109 ,  A61M16/16 ,  A61M16/161 ,  G16H20/40 ,  A61L2209/12 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M16/0465 ,  A61M16/06 ,  A61M16/0616 ,  A61M16/0666 ,  A61M16/1055 ,  A61M16/107 ,  A61M2205/3306 ,  A61M2205/3368 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/42 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/587 ,  A61M2209/10 ,  A61M2230/42

摘要： A respiratory ventilation apparatus configured to deliver a respiratory gas to a patient interface is provided. The apparatus may include a gas pressurization unit configured to generate a pressurized respiratory gas, a gas inlet port configured to introduce the respiratory gas into the respiratory ventilation apparatus, a gas outlet port configured to discharge the pressurized respiratory gas to a respiration tube, a detection module configured to detect the pressure of the pressurized respiratory gas, at least one non-volatile memory configured to store a plurality of parameters and a plurality of programs, and one or more controllers. The one or more controllers may be configured to initiate the respiratory ventilation apparatus upon a boot operation, and/or initiate a program that constantly reads information from the detection module, and controls the pressure of the pressurized respiratory gas using the information read from the detection module and at least one parameter.

公开(公告)号：US20240264144A1

公开(公告)日：2024-08-08

申请号：US18605672

申请日：2024-03-14

申请人： TransMedics, Inc.

发明人： Waleed H. HASSANEIN ,  Tamer I. KHAYAL ,  Robert HAVENER ,  Stanley KYI ,  Ihab Abdel FATTAH ,  Hesham SALEH ,  Jon C. TRACHTENBERG

IPC分类号： G01N33/49 ,  A01N1/02 ,  A61M11/00 ,  A61M11/04 ,  A61M16/00 ,  A61M16/10

CPC分类号： G01N33/4925 ,  A01N1/02 ,  A01N1/0226 ,  A01N1/0247 ,  A61M11/042 ,  A61M16/024 ,  A61M11/00 ,  A61M2016/0027 ,  A61M2016/0033 ,  A61M16/0078 ,  A61M16/10 ,  A61M2016/1025 ,  A61M2016/103 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/025 ,  A61M2202/0468 ,  A61M2205/3368 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/432

摘要： The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.

公开(公告)号：US20240245118A1

公开(公告)日：2024-07-25

申请号：US18625427

申请日：2024-04-03

申请人： Altria Client Services LLC

发明人： San LI ,  Georgios D. KARLES ,  Richard JUPE ,  Gerd KOBAL ,  Munmaya K. MISHRA

IPC分类号： A24F40/42 ,  A24D3/04 ,  A24D3/06 ,  A24D3/17 ,  A24F40/10 ,  A24F40/40 ,  A24F40/48 ,  A24F40/485 ,  A61M11/00 ,  A61M11/04 ,  A61M15/06

CPC分类号： A24F40/42 ,  A24D3/048 ,  A24D3/061 ,  A24D3/17 ,  A24F40/40 ,  A61M11/003 ,  A61M11/044 ,  A61M15/06 ,  A24F40/10 ,  A24F40/48 ,  A24F40/485 ,  A61M2205/3653 ,  A61M2205/50 ,  A61M2205/8206

摘要： An electronic smoking article includes a liquid aerosol formulation, a heater operable to at least partially volatilize the liquid aerosol formulation and form an aerosol and a tubular filter segment downstream of the heater. The tubular filter segment is operable to selectively filter aerosol particles and vapors from the aerosol.

公开(公告)号：US20240238538A1

公开(公告)日：2024-07-18

申请号：US17999215

申请日：2021-05-06

申请人： Yu GU

发明人： Yu GU

IPC分类号： A61M11/00 ,  A61M15/00

CPC分类号： A61M11/007 ,  A61M11/001 ,  A61M15/0036

摘要： A nebulizing device (100) is provided, including: a hollow housing (101), including a cavity (110). where the cavity (110) includes a liquid channel (111) located inside the cavity and a nebulizing spray nozzle (103) located at a distal end of the liquid channel (111) with a plurality of fluid outlets; and an injector (102), at least partially accommodated in the cavity (110). The injector (102) includes: a reservoir (120), configured to accommodate liquid; a liquid conveying pipe (121) including a liquid inlet (122) and a liquid outlet (123), where the liquid inlet (122) is located in the reservoir (120), the liquid outlet (123) is located in the liquid channel (111), the liquid outlet and the nebulizing spray nozzle (103) jointly define a liquid chamber (124), and the liquid conveying pipe (121) is configured to convey the liquid in the reservoir (120) into the liquid chamber (124); and an injector proximal end (102), which is coupled to the liquid conveying pipe (121) and configured to receive a pushing force, so that the liquid conveying pipe (121) is movable in the cavity (110) from a proximal position to a distal position to form a predetermined nebulizing pressure at the nebulizing spray nozzle (103), and the liquid can flow out through the nebulizing spray nozzle (103) and converge to generate a plume spray with a predetermined initial speed, where at least 50% of droplets in the plume spray have an average particle size ranging from 1 um to 10 um.

公开(公告)号：US12036355B2

公开(公告)日：2024-07-16

申请号：US17051382

申请日：2019-05-03

申请人： Boehringer Ingelheim International GmbH

发明人： Stephen Terence Dunne ,  Dana Huesch ,  Peter Rolf Werner Langguth

IPC分类号： A61M11/00 ,  A61F9/00 ,  A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K31/58 ,  A61K47/24 ,  A61K47/28 ,  A61M15/00 ,  B05B9/08 ,  B05B11/00 ,  B05B11/02 ,  B05B11/10 ,  B05B17/00

CPC分类号： A61M11/007 ,  A61F9/0008 ,  A61K9/0078 ,  A61K9/127 ,  A61K47/24 ,  A61K47/28 ,  B05B9/0822 ,  B05B17/00 ,  A61K9/0048 ,  A61K9/1075 ,  A61K31/58 ,  A61M15/0035 ,  A61M2205/071 ,  B05B11/0054 ,  B05B11/026 ,  B05B11/028 ,  B05B11/1091

摘要： A system includes a nebulizer for nebulizing a fluid from a container and such a container containing a fluid and are proposed. The fluid is a non-newtonian fluid, in form of a suspension or emulsion or a liposomal fluid or a gel. The nebulizer includes a fluid pump for withdrawing the fluid in doses from the container and pressurizing the respective doses for nebulization through nozzle channels having a hydraulic diameter in the range of 3 to 20 microns at an operational pressure of 5 to 250 MPa.