公开(公告)号：US12109356B2

公开(公告)日：2024-10-08

申请号：US18239551

申请日：2023-08-29

申请人： De Motu Cordis Pty Ltd

发明人： Brendan O'Flaherty ,  Johann Lipman ,  Patrick Joseph Lynch ,  John Fredatovich

IPC分类号： A61M15/00

CPC分类号： A61M15/0041 ,  A61M15/0008 ,  A61M15/0025 ,  A61M15/0035 ,  A61M2202/064 ,  A61M2205/273

摘要： The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.

公开(公告)号：US20240198020A1

公开(公告)日：2024-06-20

申请号：US18362449

申请日：2023-07-31

申请人： Civitas Therapeutics, Inc.

发明人： Colleen Ellwanger ,  Brian Noble ,  Tim Coker ,  Sean Plunkett

IPC分类号： A61M15/00

CPC分类号： A61M15/0028 ,  A61M15/0035 ,  A61M15/0041 ,  A61M2202/064

摘要： A device for puncturing a capsule to release a powdered medicament therefrom includes a chamber for receiving the capsule. The capsule includes opposing domes and a cylindrical wall portion defined by a capsule wall radius r. The device further includes a mechanism for puncturing at least one hole in at least one dome. A center of each hole is located within an annular puncture region situated at no less than 0.4 r, and a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule. The annular puncture region may, for example, be situated between about 0.4 r and about 0.8 r, or between about 0.4 r and about 0.6 r.

公开(公告)号：US20240091468A1

公开(公告)日：2024-03-21

申请号：US18039590

申请日：2021-12-09

申请人： PHILIP MORRIS PRODUCTS, S.A.

发明人： Onur DAYIOGLU

IPC分类号： A61M15/00

CPC分类号： A61M15/0035 ,  A61M15/0021 ,  A61M2202/064

摘要： An inhaler system includes a housing defining a housing cavity, a sleeve extending along a sleeve longitudinal axis and positioned within the housing cavity, a capsule is contained within the sleeve and having a capsule longitudinal axis, and a piercing element having only a single shaft extending from a fixed end to a tip along a piercing element longitudinal axis, the piercing element longitudinal axis being parallel with and offset from the capsule longitudinal axis. Only a single aperture is formed in the capsule by the piercing element.

公开(公告)号：US20240058554A1

公开(公告)日：2024-02-22

申请号：US18023622

申请日：2021-08-31

申请人： JANSSEN PHARMACEUTICA NV

发明人： David RAMOS ,  Monica A. KAPIL ,  Chaley John LARSON ,  Steven J. SCHWARZ ,  Emma Louise HUBERT ,  Hong YAN

IPC分类号： A61M15/00

CPC分类号： A61M15/0035

摘要： Various exemplary drug delivery devices with propellant, drug products utilizing the same, and methods of using drug delivery devices with propellant are provided. In general, a nasal drug delivery device is configured to expel a drug into a nose of a patient and to drive delivery of the drug using a propellant. The propellant includes a gas, e.g., air, carbon dioxide, etc., and/or at least one material substance configured to produce energy that causes movement of the drug out of an opening of the drug delivery device.

公开(公告)号：US11766529B2

公开(公告)日：2023-09-26

申请号：US16325612

申请日：2017-08-10

申请人： Alfred Von Schuckmann

发明人： Alfred Von Schuckmann

IPC分类号： A61M15/00 ,  A61M11/00

CPC分类号： A61M15/0041 ,  A61M11/00 ,  A61M11/003 ,  A61M15/00 ,  A61M15/003 ,  A61M15/0023 ,  A61M15/0026 ,  A61M15/0028 ,  A61M15/0035 ,  A61M15/0001 ,  A61M15/0021 ,  A61M15/0025 ,  A61M2202/064

摘要： A device for inhaling powdery substances contained in capsules has a housing, a capsule receiver, a closing cover, a mouth piece, and a closure cap. The closure cap is designed to cover simultaneously the mouthpiece, closing cover and capsule receiver, wherein the closure cap, mouthpiece and closing cover are hinged in a pivoting manner. Two pivot axes, which are different but run in the same direction, are formed, which, in respect of a side view in which geometric axes of the pivot axes are represented in the form of points, are arranged next to each other and on a same side of the capsule receiver. In a usage state of the device, the first pivot axis is arranged closer to the capsule receiver. The closing cover and the mouthpiece can be pivoted about the first pivot axis and only the closure cap can be pivoted about the second pivot axis.

公开(公告)号：US11690819B2

公开(公告)日：2023-07-04

申请号：US17682033

申请日：2022-02-28

申请人： Impel Pharmaceuticals Inc.

发明人： John D. Hoekman ,  Kelsey H. Satterly ,  Inna Dashevsky ,  Aditya R. Das ,  Stephen B. Shrewsbury ,  Gregory J. Davies ,  Bhavin Y. Gajera

IPC分类号： A61K31/198 ,  A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/48 ,  A61K31/165 ,  A61M11/02 ,  A61M15/00 ,  A61M15/08 ,  A61P25/16

CPC分类号： A61K31/198 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/48 ,  A61K31/165 ,  A61M11/02 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/0036 ,  A61M15/08 ,  A61P25/16 ,  A61M15/009 ,  A61M2202/04 ,  A61M2202/064 ,  A61M2205/8225 ,  A61M2206/20

摘要： A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.

公开(公告)号：US20230181849A1

公开(公告)日：2023-06-15

申请号：US18164836

申请日：2023-02-06

申请人： OptiNose, Inc.

发明人： Per Gisle DJUPESLAND ,  Roderick Peter HAFNER ,  Colin David SHELDRAKE

IPC分类号： A61M15/08 ,  A61M15/00 ,  A61M16/12 ,  A61M16/00 ,  A61M16/10

CPC分类号： A61M15/08 ,  A61M15/0035 ,  A61M15/0041 ,  A61M15/0098 ,  A61M16/127 ,  A61M15/0028 ,  A61M15/0021 ,  A61M15/0086 ,  A61M16/0066 ,  A61M15/003 ,  A61M16/105 ,  A61M16/1075 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/3606 ,  A61M2205/3673 ,  A61M2205/8218 ,  A61M2206/14 ,  A61M2210/0618 ,  A61M2210/0625 ,  A61M2205/076

摘要： A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.

公开(公告)号：US11660407B2

公开(公告)日：2023-05-30

申请号：US17787716

申请日：2021-05-07

申请人： Eli Lilly and Company

发明人： Jaime Ray Arnett

IPC分类号： A61M15/00 ,  A61M15/08

CPC分类号： A61M15/0041 ,  A61M15/0031 ,  A61M15/0035 ,  A61M15/0061 ,  A61M15/08 ,  A61M2202/064 ,  A61M2205/8281

摘要： The present disclosure provides a nasal delivery device with a device body that includes a trigger end and an outlet end. The nasal delivery device also includes a trigger assembly coupled to the trigger end of the device body, a drug container supported by the device body, and a spring-loaded activator assembly supported by the device body and disposed between the trigger assembly and the drug container.

公开(公告)号：US20190231998A1

公开(公告)日：2019-08-01

申请号：US16328198

申请日：2017-08-25

申请人： Nerudia Limited

发明人： Chris LORD ,  David JONES ,  Kenneth SCOTT ,  Stephen MCDONALD ,  Thomas SUDLOW

IPC分类号： A61M15/06 ,  A24F47/00 ,  A61M15/00 ,  A61M11/04

CPC分类号： A61M15/06 ,  A24F47/008 ,  A61M11/042 ,  A61M15/0021 ,  A61M15/0035 ,  A61M15/0041 ,  A61M2205/3653 ,  A61M2205/8206

摘要： There is disclosed a device for nicotine delivery, comprising: a vapour outlet conduit for coupling to, and for fluid communication with, a vapour creation system, said vapour outlet conduit defining a fluid passage therethrough for delivery of vapour from a vapour creation system to a user, wherein said vapour outlet conduit comprises a nicotine carrier unit region configured to accept a nicotine carrier unit and retain said nicotine carrier unit in said fluid passage. Also disclosed is a system for nicotine delivery and kits-of-parts for assembling the device and system.

公开(公告)号：US20180325777A1

公开(公告)日：2018-11-15

申请号：US15769314

申请日：2016-08-08

申请人： Capsugel Belgium NV

发明人： Tom Huysmans ,  Tarryn Dierckx ,  Stefaan Jaak Vanquickenborne

IPC分类号： A61J3/07 ,  C09J103/02 ,  A61J3/00

CPC分类号： A61J3/072 ,  A61J3/005 ,  A61K9/4808 ,  A61M15/0035 ,  A61M2202/064 ,  C08K5/05 ,  C08L3/02 ,  C09J5/00 ,  C09J103/02 ,  C09J105/00 ,  C09J2403/00 ,  C09J2405/00

摘要： A tamperproof dosage form for oral administration comprising a cap and a body each comprising an outer surface and an inner surface, the cap and body being arranged to telescopically engage with each other such that an overlap region is 5 formed between a portion of the outer surface of the body and a portion of the inner surface of the cap, said overlap region comprising an overlap length extending parallel to a centerline of said dosage form, wherein an adhesive substance is comprised throughout substantially the entire overlap length bonding said cap to said body.