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公开(公告)号：US11690819B2
公开(公告)日：2023-07-04
申请号：US17682033
申请日：2022-02-28
发明人： John D. Hoekman , Kelsey H. Satterly , Inna Dashevsky , Aditya R. Das , Stephen B. Shrewsbury , Gregory J. Davies , Bhavin Y. Gajera
IPC分类号： A61K31/198 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/48 , A61K31/165 , A61M11/02 , A61M15/00 , A61M15/08 , A61P25/16
CPC分类号： A61K31/198 , A61K9/0043 , A61K9/0053 , A61K9/0075 , A61K9/14 , A61K9/1623 , A61K9/1652 , A61K9/48 , A61K31/165 , A61M11/02 , A61M15/003 , A61M15/0035 , A61M15/0036 , A61M15/08 , A61P25/16 , A61M15/009 , A61M2202/04 , A61M2202/064 , A61M2205/8225 , A61M2206/20
摘要： A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.
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公开(公告)号：US20220296504A1
公开(公告)日：2022-09-22
申请号：US17498381
申请日：2021-10-11
IPC分类号： A61K9/00 , A61P25/16 , A61M15/00 , A61K31/198 , A61K9/16 , A61K31/197
摘要： Methods are provided for treating OFF episodes in a patient with Parkinson's disease or a Parkinson syndrome, comprising administering to a subject with Parkinson's disease or a Parkinson syndrome experiencing an OFF episode an effective dose of a dry pharmaceutical composition comprising L-DOPA, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma levodopa concentration (Cmax) of at least 200 ng/mL, with (b) a mean time to Cmax (Tmax) of levodopa of less than or equal to 60 minutes. Dry pharmaceutical compositions of levodopa suitable for intranasal administration and unit dosage forms comprising the dry pharmaceutical compositions are also provided.
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公开(公告)号：US11517548B2
公开(公告)日：2022-12-06
申请号：US16517423
申请日：2019-07-19
发明人： John D. Hoekman , Kelsey H. Satterly , Inna Dashevsky , Aditya R. Das , Stephen B. Shrewsbury , Gregory J. Davies , Bhavin Y. Gajera
IPC分类号： A61K31/198 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/48 , A61K31/165 , A61M11/02 , A61M15/00 , A61M15/08 , A61P25/16
摘要： A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.
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4.发明公开公开(公告)号：US20230301955A1
公开(公告)日：2023-09-28
申请号：US18313330
申请日：2023-05-06
发明人： John D. Hoekman , Kelsey H. Satterly , Inna Dashevsky , Aditya R. Das , Stephen B. Shrewsbury , Gregory J. Davies , Bhavin Y. Gajera
IPC分类号： A61K31/198 , A61P25/16 , A61K9/00 , A61M15/00 , A61M11/02 , A61M15/08 , A61K9/16 , A61K31/165 , A61K9/48 , A61K9/14
CPC分类号： A61K31/198 , A61P25/16 , A61K9/0075 , A61M15/0036 , A61M11/02 , A61M15/003 , A61M15/08 , A61M15/0035 , A61K9/0043 , A61K9/1623 , A61K9/1652 , A61K31/165 , A61K9/48 , A61K9/14 , A61K9/0053 , A61M15/009 , A61M2202/04 , A61M2202/064 , A61M2206/20 , A61M2205/8225
摘要： A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.
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公开(公告)号：US20220233486A1
公开(公告)日：2022-07-28
申请号：US17682033
申请日：2022-02-28
发明人： John D. Hoekman , Kelsey H. Satterly , Inna Dashevsky , Aditya R. Das , Stephen B. Shrewsbury , Gregory J. Davies , Bhavin Y. Gajera
IPC分类号： A61K31/198 , A61P25/16 , A61K9/00
摘要： A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.
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