公开(公告)号：US10696686B2

公开(公告)日：2020-06-30

申请号：US14894698

申请日：2014-05-29

Applicant: Syngenta Limited

Inventor： Janice Black ,  James Nicholas Scutt ,  Louisa Whalley ,  Nigel James Willets

IPC: C07D493/08 ,  A01N43/16 ,  C07D309/32 ,  C07D311/96 ,  C07C49/753 ,  A01N43/18 ,  C07C323/22 ,  A01N43/40 ,  C07D307/42 ,  A01N35/06 ,  A01N37/02 ,  A01N37/10 ,  A01N47/06 ,  C07C49/577 ,  C07C69/24 ,  C07C69/78 ,  C07C69/96 ,  C07C381/14 ,  A01N43/90 ,  C07C49/517

Abstract: The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R1 is fluorine or bromine; R2 is ethynyl, C1-C3alkoxy, C1-C3haloalkoxy, or C1-C3alkoxy-C1-C3alkoxy-; and Q is a pyran-3,5-dione-4-yl, a thiopyran-3,5-dione-4-yl, a piperidine-3,5-dione-4-yl, a cyclopentane-1,3-dione-2-yl, a cyclohexane-1,3, 5-trione-2-yl, a cyclohexane-1,3-dione-2-yl, or a cycloheptane-1,3-dione-2-yl, or a derivative thereof (e.g. a fused such as fused bicyclic derivative, and/or a spirocyclic derivative), or an enol ketone tautomer derivative thereof, wherein Q is further defined herein; and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. Preferably, X is methyl; and/or R1 is fluorine; and/or R2 is —O—R2A, wherein R2A is methyl, ethyl, trifluoromethyl, difluoromethyl, trifluoroethyl, or —CH2CH2OCH3. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the weeds and/or to the plants and/or to the locus thereof.

公开(公告)号：US20150051293A1

公开(公告)日：2015-02-19

申请号：US14315809

申请日：2014-10-14

Applicant: KYOTO UNIVERSITY

Inventor： Noriyuki TSUMAKI ,  Hiroshi TAKEMORI ,  Hiroyuki FUCHINO ,  Nobuo KAWAHARA

IPC: C07C49/517 ,  C07C49/513

CPC classification number: A61K31/122

Abstract: An object of the present invention is to provide a therapeutic preparation and method for diseases associated with cartilage loss, cartilage degeneration and/or cartilage thinning. The present invention provides a therapeutic preparation comprising a pterosin derivative or a pharmaceutically acceptable salt thereof for diseases associated with cartilage loss, cartilage degeneration and/or cartilage thinning; and a therapeutic method for the diseases.

Abstract translation: 本发明的目的是提供与软骨损失，软骨变性和/或软骨变薄相关的疾病的治疗制剂和方法。 本发明提供包含蝶呤蛋白衍生物或其药学上可接受的盐的治疗制剂，用于与软骨损失，软骨变性和/或软骨变薄相关的疾病; 和疾病的治疗方法。

公开(公告)号：US20090054530A1

公开(公告)日：2009-02-26

申请号：US12197686

申请日：2008-08-25

Applicant: Daryoush Parkhideh

Inventor： Daryoush Parkhideh

IPC: A61K31/122 ,  C07C49/517 ,  A61P43/00 ,  B32B1/00

CPC classification number: A61K31/355 ,  A23L33/15 ,  A23V2002/00 ,  A23V2200/25 ,  A61K9/14 ,  A61K31/12 ,  A61K31/122 ,  Y10S977/775 ,  Y10T428/2982 ,  A61K2300/00 ,  A23V2250/314

Abstract: Bioavailability of Coenzyme-Q 10 (“Co-Q10”), an oil-soluble substance, can be enhanced in a subject by modifying, e.g. nanonizing or charging, the form of Co-Q10. Co-Q10 bioavailability also can be enhanced by administering Co-Q10 to the subject as an oil (lipid)-based and water (hydro)-based mixed composition, along with other optional components, such as oils, resins and other carriers. Accordingly, the invention provides various Co-Q10 compositions, e.g. compositions comprised of (i) Co-Q10 dissolved in one or more Co-Q10-soluble oils and (ii) Co-Q10 in admixture with at least one water-dispersible agent. A Co-Q10 complex of the invention, therefore, yields an increased cell absorption rate, as well as an enhanced percentage of Co-Q10 peak absorption, compared to previously known compounds. Methods for making and using the aforementioned compositions also are provided.

Abstract translation: 辅酶Y10（“Co-Q10”）的生物利用度，油溶性物质可通过修饰，例如， 纳米化或充电，形式为Co-Q10。 通过向受试者施用基于油（脂质）的和水（基于水）的混合组合物以及其它任选的组分如油，树脂和其它载体，可以提高Co-Q10生物利用度。 因此，本发明提供了各种Co-Q10组合物，例如 包含（i）溶解在一种或多种Co-Q10可溶性油中的Co-Q10和（ii）与至少一种水分散性试剂混合的Co-Q10的组合物。 因此，与先前已知的化合物相比，本发明的Co-Q10复合物产生增加的细胞吸收速率，以及增加的Co-Q10峰吸收百分比。 还提供了制备和使用上述组合物的方法。

公开(公告)号：US06953792B2

公开(公告)日：2005-10-11

申请号：US10276129

申请日：2001-05-16

Applicant: Jose Luis Castro Pineiro ,  Kevin Dinnell ,  Jason Matthew Elliot ,  Gregory John Hollingworth ,  Duncan Edward Shaw ,  Christopher John Swain ,  Lihu Yang

Inventor： Jose Luis Castro Pineiro ,  Kevin Dinnell ,  Jason Matthew Elliot ,  Gregory John Hollingworth ,  Duncan Edward Shaw ,  Christopher John Swain ,  Lihu Yang

IPC: C07D295/04 ,  A61K31/075 ,  A61K31/12 ,  A61K31/135 ,  A61K31/16 ,  A61K31/165 ,  A61K31/215 ,  A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/403 ,  A61K31/41 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/4355 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/451 ,  A61K31/472 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/54 ,  A61K31/55 ,  A61P1/08 ,  A61P25/04 ,  A61P25/06 ,  A61P25/22 ,  A61P25/24 ,  A61P29/00 ,  A61P43/00 ,  C07C43/178 ,  C07C45/29 ,  C07C49/497 ,  C07C49/517 ,  C07C49/697 ,  C07C49/747 ,  C07C49/753 ,  C07C69/757 ,  C07C69/767 ,  C07C217/48 ,  C07C217/52 ,  C07C229/22 ,  C07C233/23 ,  C07C233/31 ,  C07C233/32 ,  C07C233/58 ,  C07C233/59 ,  C07C235/40 ,  C07C235/80 ,  C07C235/82 ,  C07C237/04 ,  C07C237/08 ,  C07C237/24 ,  C07D207/06 ,  C07D207/16 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/38 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D211/74 ,  C07D213/38 ,  C07D217/04 ,  C07D233/90 ,  C07D241/08 ,  C07D257/04 ,  C07D265/30 ,  C07D275/04 ,  C07D277/28 ,  C07D295/08 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15 ,  C07D295/155 ,  C07D295/185 ,  C07D295/192 ,  C07D295/205 ,  C07D307/52 ,  C07D317/72 ,  C07D333/20 ,  C07D401/04 ,  C07D401/06 ,  C07D413/04 ,  C07D417/12 ,  C07D487/08 ,  C07D491/20 ,  C07D295/16

CPC classification number: C07D295/185 ,  C07B2200/09 ,  C07C45/29 ,  C07C49/697 ,  C07C49/747 ,  C07C49/753 ,  C07C217/52 ,  C07C233/23 ,  C07C233/31 ,  C07C233/58 ,  C07C233/59 ,  C07C235/40 ,  C07C235/82 ,  C07C237/04 ,  C07C237/24 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D211/48 ,  C07D211/58 ,  C07D213/38 ,  C07D241/08 ,  C07D295/096 ,  C07D295/15 ,  C07D295/155 ,  C07D295/192 ,  C07D295/205 ,  C07D401/06 ,  C07C47/228

Abstract: The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R?17, R18, R19, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

Abstract translation: 本发明涉及式（I）的化合物：其中环A为苯基或吡啶环; X代表选自（a），（b），（c），（d），（e），（f），（g），（h），（i），（j） ，（k），（1）和R 1，R 2，R 3，R 4，R R 5，R 6，R 7，R 13，R 14，R 14， R 16，R 16，R 17，R 18，R 19，R 21a， SUP>和R 21b如本文所定义。 该化合物特别用于治疗或预防抑郁，焦虑，疼痛，炎症，偏头痛，呕吐或带状疱疹后神经痛。

公开(公告)号：US6118017A

公开(公告)日：2000-09-12

申请号：US291576

申请日：1999-04-08

Applicant: Siegfried B. Christensen, IV ,  Cornelia J. Forster

Inventor： Siegfried B. Christensen, IV ,  Cornelia J. Forster

IPC: A61P11/00 ,  A61K31/215 ,  A61K31/275 ,  A61P11/06 ,  A61P43/00 ,  C07C45/59 ,  C07C49/517 ,  C07C49/755 ,  C07C69/157 ,  C07C69/757 ,  C07C251/44 ,  C07C255/46 ,  C07C255/00 ,  C07C49/23 ,  C07C205/00 ,  C07C229/00 ,  C07C249/00

CPC classification number: C07C255/46 ,  C07C45/59 ,  C07C49/755 ,  C07C69/757 ,  C07C2101/04 ,  C07C2101/08

Abstract: This invention relates to ketones, alcohols and amines and acids represented by the likes of 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylcyanoclobutan-1-one. They are useful as PDE 4 antngionists.

Abstract translation: 本发明涉及由3-（3-环戊氧基-4-甲氧基苯基）-3-苯基氰基聚丁烯-1-酮代表的酮，醇和胺和酸。 它们作为PDE 4 antionionists有用。

公开(公告)号：US5886233A

公开(公告)日：1999-03-23

申请号：US765102

申请日：1997-08-08

Applicant: Andreas Steinmeyer ,  Gunter Neef ,  Gunnar Muller ,  Hans-Joachim Knolker

Inventor： Andreas Steinmeyer ,  Gunter Neef ,  Gunnar Muller ,  Hans-Joachim Knolker

IPC: C07D307/20 ,  C07C39/10 ,  C07C43/188 ,  C07C43/196 ,  C07C45/29 ,  C07C45/40 ,  C07C45/69 ,  C07C49/172 ,  C07C49/497 ,  C07C49/517 ,  C07C49/577 ,  C07C49/647 ,  C07C67/42 ,  C07C69/013 ,  C07C69/16 ,  C07C69/28 ,  C07C251/34 ,  C07C251/44 ,  C07F7/08 ,  C07F7/18 ,  C07C49/29

CPC classification number: C07F7/1852 ,  C07C251/44 ,  C07C43/188 ,  C07C43/196 ,  C07C45/29 ,  C07C45/40 ,  C07C45/69 ,  C07C49/497 ,  C07C49/517 ,  C07C49/577 ,  C07C49/647 ,  C07C69/013

Abstract: Described are cyclohexanone derivatives of the formula (I), a method of preparing them and intermediates used in their preparation. ##STR1##

Abstract translation: PCT No.PCT / EP95 / 02274。 371日期：1997年8月8日 102（e）日期1997年8月8日PCT Filed Jun。13，1995 PCT Pub。 公开号WO96 / 00207 日期1996年1月4日描述了式（I）的环己酮衍生物，其制备方法和其制备中使用的中间体。 （一）

公开(公告)号：US5223647A

公开(公告)日：1993-06-29

申请号：US902734

申请日：1992-06-23

Applicant: Shunich Maemoto ,  Akira Iwasaki ,  Junzo Hasegawa

Inventor： Shunich Maemoto ,  Akira Iwasaki ,  Junzo Hasegawa

IPC: C07C67/56 ,  C07B57/00 ,  C07C45/78 ,  C07C45/85 ,  C07C49/497 ,  C07C49/517 ,  C07C67/58 ,  C07C69/76

CPC classification number: C07C45/78 ,  C07C45/85

Abstract: The present invention discloses a separating and purifying (4R, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone comprising the steps of:reacting a diastereomer mixture of (4R, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone represented by the formula (I) ##STR1## and (4S, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone represented by the formula (II) ##STR2## with a reagent which reacts with the hydroxyl groups at least equimolar to the compound represented by the formula (II) to thereby convert the compound represented by the formula (II) into (4S, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone derivative represented by the formula (III) ##STR3## (where R represents a group modifying the hydroxyl group) by modification with priority of the hydroxyl group in the formula (II), andseparating the compound of the formula (I) from the compound of the formula (III) through the difference in solubility to water or an organic solvent. According to the invention, (4R, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone is easily separated with a high yield.

公开(公告)号：US5019655A

公开(公告)日：1991-05-28

申请号：US363252

申请日：1989-06-08

Applicant: Guy P. Adrian

Inventor： Guy P. Adrian

IPC: C07C45/68 ,  C07C45/00 ,  C07C45/42 ,  C07C45/45 ,  C07C45/51 ,  C07C49/453 ,  C07C49/483 ,  C07C49/517 ,  C07C49/697 ,  C07C49/755 ,  C07C67/00

CPC classification number: C07C45/512 ,  C07C45/00 ,  C07C45/42 ,  C07C49/697 ,  C07C49/755

Abstract: Method of preparing 4-disubstituted phenyl-1-tetralones of formula ##STR1## in which X represents halogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy and Y, situated in position 2' or 3', represents halogen or C.sub.1 -C.sub.4 alkyl, this method being characterized in that it comprises the reaction, in the presence of an acid agent, of .alpha.-naphthol of formula (II) with a phenyl compound of formula (III): ##STR2## where X represents halogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, and Y is situated in the ortho or meta position with respect to X and represents halogen or C.sub.1 -C.sub.4 alkyl.

Abstract translation: 制备其中X表示卤素，C 1 -C 4烷基或C 1 -C 4烷氧基和位于2'或3'位置的Y的式（Ⅰ）的4-二取代苯基-1-四氢萘酮的方法代表卤素或C1 -C4烷基，该方法的特征在于其包含式（II）的α-萘酚在酸存在下与式（III）的苯基化合物反应：图像（II） （III）其中X表示卤素，C 1 -C 4烷基或C 1 -C 4烷氧基，Y相对于X位于邻位或间位，代表卤素或C1-C4烷基。

公开(公告)号：US4983584A

公开(公告)日：1991-01-08

申请号：US124139

申请日：1987-11-23

Applicant: Chikara Fukaya ,  Hitoshi Yasuda ,  Toshiaki Akira ,  Masakazu Iwai ,  Kanemichi Okano ,  Kazumasa Yokoyama

Inventor： Chikara Fukaya ,  Hitoshi Yasuda ,  Toshiaki Akira ,  Masakazu Iwai ,  Kanemichi Okano ,  Kazumasa Yokoyama

IPC: A61K31/045 ,  A61K31/075 ,  A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/70 ,  C07C47/192 ,  C07C47/198 ,  C07C49/11 ,  C07C49/172 ,  C07C49/175 ,  C07C49/497 ,  C07C49/517

CPC classification number: A61K31/7004 ,  A61K31/045 ,  A61K31/075 ,  A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/70 ,  C07C47/192 ,  C07C47/198 ,  C07C49/11 ,  C07C49/172 ,  C07C49/175 ,  C07C49/497 ,  C07C49/517 ,  Y10S514/927

Abstract: A therapeutic and prophylactic agent for peptic ulcers comprising as an effective ingredient a cyclohexane derivative represented by general formula (I): ##STR1## wherein A represents a group shown by formula, >CH.sub.2, ##STR2## wherein X represents ethynylene, vinylene or ethylene, Y represents oxo or a hydroxy group; R.sup.1, R.sup.3, R.sup.4 and R.sup.5 each represents a hydrogen atom or alkyl; R.sup.2 represents a hydrogen atom, alkyl or a group shown by --OR.sup.8 ;R.sup.6 represents a hydrogen atom, oxo or a group shown by --OR.sup.8 ; and R.sup.7 represents a hydrogen atom or a group shown by --OR.sup.8, wherein R.sup.8 represents a hydrogen atom or an organic residue.

公开(公告)号：US4849454A

公开(公告)日：1989-07-18

申请号：US855905

申请日：1986-04-24

Applicant: Marie-Madeleine Bouton ,  Jean Jacques ,  Andre Pierdet

Inventor： Marie-Madeleine Bouton ,  Jean Jacques ,  Andre Pierdet

IPC: C07C69/013 ,  A61K8/00 ,  A61K8/11 ,  A61K8/35 ,  A61K8/37 ,  A61K8/49 ,  A61K31/045 ,  A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/455 ,  A61P17/00 ,  A61P43/00 ,  A61Q5/00 ,  C07C45/00 ,  C07C45/61 ,  C07C45/67 ,  C07C49/513 ,  C07C49/517 ,  C07C49/737 ,  C07C49/753 ,  C07C67/00 ,  C07C69/03 ,  C07C69/08 ,  C07C313/00 ,  C07C323/13 ,  C07D213/79 ,  C07D213/80 ,  C07D317/70 ,  C07D317/72

CPC classification number: C07D213/80 ,  C07C49/513 ,  C07D317/70 ,  C07D317/72 ,  C07C2103/16

Abstract: Novel antiandrogenic compositions comprising an anti-androgenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

Abstract translation: 包含抗雄激素有效量的至少一种式I的化合物的新型抗雄激素组合物，其中R是1至4个碳原子的烷基，R 1是1至2个碳原子的烷基，R 2选自 氢原子，任选被杂原子间隔的1至8个碳原子的烷基，2至8个碳原子的链烯基和炔基任选地被2至18个碳原子的有机羧酸的杂原子，甲酰基和酰基中断，R3选自 由氢，1至4个碳原子的烷基和2至4个碳原子的烯基和炔基组成的组，R 4选自氢和1至4个碳原子的烷基，虚线表示任选地存在 4（5）和5a（6）碳之间的双键和波浪线表示R4可以是α或β-位，一个无毒的药物载体或赋形剂和一种在温暖中治疗雄激素过多的条件的方法 -bl 被传染的动物。