公开(公告)号：US20220168471A1

公开(公告)日：2022-06-02

申请号：US17245150

申请日：2021-04-30

Applicant: Toray Industries, Inc.

Inventor： Rumiko Kitagawa ,  Masataka Nakamura

IPC: A61L27/50 ,  A61L31/04 ,  A61L33/06 ,  A61K9/70 ,  A61L15/00 ,  B05D7/24 ,  B32B27/30 ,  A61L27/00 ,  A61L27/36

Abstract: A device includes a substrate and a hydrophilic polymer layer made of a hydrophilic polymer having a hydroxyl group. The hydrophilic polymer layer having a hydroxyl group is fixed to at least a part of a surface of the substrate and the hydrophilic polymer further has an amide group. A liquid film retention time of the device is 15 seconds or more. The device has a surface of a substrate which is hydrophilized. A method for producing the device by a simple method is also disclosed.

公开(公告)号：US11118067B2

公开(公告)日：2021-09-14

申请号：US15879526

申请日：2018-01-25

Applicant: President and Fellows of Harvard College

Inventor： Joanna Aizenberg ,  Michael Aizenberg ,  Sung Hoon Kang ,  Philseok Kim ,  Tak Sing Wong

IPC: B05D3/00 ,  C09D5/00 ,  C09D5/16 ,  A61L27/28 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00 ,  A61L33/06 ,  B01L3/00 ,  B65D25/14 ,  H01L31/0236 ,  G02B1/14 ,  C10M105/54 ,  C10M105/56 ,  F01D25/18 ,  F15D1/02 ,  F15D1/10 ,  F28F13/18 ,  F28F19/02 ,  B05D5/00 ,  B01D69/02 ,  B05D5/08 ,  B63B59/04 ,  B64D15/00 ,  C02F1/44 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F16L57/00 ,  H01L31/0216

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). Slippery liquid-infused porous surfaces outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (

公开(公告)号：US20210177567A1

公开(公告)日：2021-06-17

申请号：US17183543

申请日：2021-02-24

Applicant: Xeltis, A.G.

Inventor： Luke David Burke ,  Martijn Antonius Johannes Cox ,  Aurelie Serrero

IPC: A61F2/00 ,  A61L33/00 ,  A61L33/06 ,  A61L31/14 ,  A61L31/16 ,  A61L31/04 ,  A61F2/06 ,  A61L27/18 ,  A61M1/36

Abstract: A cardiovascular graft is provided with highly reduced thrombogenicity. The cardiovascular graft is an electrospun non-woven mesh produced from supramolecular polymers with large diameter fibers. The cardiovascular graft can be implemented as a vascular graft into the human body to allow vascular bypass/reconstruction, or repeated venous access for dialysis treatment, as well as other disorders of small-diameter blood vessels.

公开(公告)号：US11020511B2

公开(公告)日：2021-06-01

申请号：US16070664

申请日：2017-02-22

Applicant: Toray Industries, Inc.

Inventor： Rumiko Kitagawa ,  Masataka Nakamura

IPC: A61L27/50 ,  A61L15/00 ,  A61L27/36 ,  A61L31/04 ,  B32B27/30 ,  A61L33/06 ,  A61K9/70 ,  B05D7/24 ,  A61L27/00

Abstract: A device includes a substrate and a hydrophilic polymer layer made of a hydrophilic polymer having a hydroxyl group. The hydrophilic polymer layer having a hydroxyl group is fixed to at least a part of a surface of the substrate and the hydrophilic polymer further has an amide group. A liquid film retention time of the device is 15 seconds or more. The device has a surface of a substrate which is hydrophilized. A method for producing the device by a simple method is also disclosed.

公开(公告)号：US10786606B2

公开(公告)日：2020-09-29

申请号：US15753266

申请日：2016-08-19

Applicant: Anteo Technologies Pty Ltd

Inventor： Nobuyoshi Joe Maeji ,  Chang-Yi Huang

IPC: A61L33/00 ,  A61K47/69 ,  A61K47/54 ,  A61K31/727 ,  A61L33/04 ,  A61L33/06 ,  B82Y30/00

Abstract: The present invention relates to the coating of a range of functional heparins onto the surface of a substrate for which hemocompatibility is a key functional characteristic, such that the functionality of the functional heparin is maintained. The approach employs a metal coordination complex to bind to the substrate with the functional heparin binding to the metal coordination complex to thereby impart hemocompatibility.

公开(公告)号：US10391205B2

公开(公告)日：2019-08-27

申请号：US15362322

申请日：2016-11-28

Applicant: National University Corporation Yamagata University ,  NIPPON SHOKUBAI CO., LTD.

Inventor： Masaru Tanaka ,  Naoki Kobayashi ,  Yoshitomo Nakata ,  Asuka Sugawara

IPC: C08F220/12 ,  C08F220/18 ,  A61L33/06 ,  C08F220/28

Abstract: To Provide is a polymer having high antithrombogenicity compared to a conventional polymer having a glycerol group and suitable as a medical device material. It is the polymer having a structural unit derived from a glycerol group-containing monomer, and a structural unit derived from an unsaturated monomer having a structure in which an organic group having a structure site having 4 or more carbon atoms continuously bound is bound to an ethylenically unsaturated group; and satisfying a glass-transition temperature of 10° C. or less and/or a glass-transition temperature of −25° C. or less at a saturated water content.

公开(公告)号：US10363342B2

公开(公告)日：2019-07-30

申请号：US15419369

申请日：2017-01-30

Applicant: Insulet Corporation

Inventor： Bryan Dillon ,  Bryan Choate

IPC: A61L29/16 ,  A61M5/158 ,  A61M5/142 ,  A61L29/06 ,  A61L29/08 ,  A61L33/06

Abstract: Various embodiments of the present invention include a cannula coated or compounded with a material to extend the wear time for a patient by reducing inflammation and therefore increasing the time that the cannula may remain inserted, thereby increasing the effectiveness of the drug delivered using the cannula. The material may include a hydrophilic material, an anti-microbial material, an anti-inflammatory material, anti-thrombogenic material, or a combination of any of these materials.

公开(公告)号：US10350334B2

公开(公告)日：2019-07-16

申请号：US15659960

申请日：2017-07-26

Applicant: Becton, Dickinson and Company

Inventor： John J. Kelley, III ,  Thelma I. Valdes

IPC: A61L33/00 ,  A61K31/167 ,  A61K31/245 ,  A61K31/47 ,  A61K9/00 ,  A61K31/445 ,  A61L29/14 ,  A61L29/16 ,  A61L29/06 ,  A61L33/04 ,  A61L33/06 ,  A61K47/36 ,  A61M25/00

Abstract: The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide; an amino ester; an aminoacylanilide; an aminoalkyl benzoate; an amino carbonate; an N-phenylamidine compound; an N-aminoalkyl amid; an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine.

公开(公告)号：US10308745B2

公开(公告)日：2019-06-04

申请号：US15556002

申请日：2016-03-15

Applicant: Toray Industries, Inc.

Inventor： Suguru Ushiro ,  Hiroshi Takahashi ,  Yoshiyuki Ueno

IPC: C08F226/10 ,  B01D71/44 ,  B01D71/68 ,  A61K35/16 ,  A61M1/16 ,  A61M1/34 ,  B01D71/76 ,  C09D139/06 ,  C08F218/10 ,  B01D67/00 ,  B01D69/06 ,  B01D69/08 ,  A61L33/06 ,  C08F226/06 ,  B01D71/38

Abstract: A copolymer has blood compatibility and antithrombotic properties of greatly suppressing protein adhesion to be usable even when in contact with a biological component such as blood for a long period of time, and a medical device uses the copolymer. The copolymer is characterized by including a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit contains at least one type of a carboxylic acid vinyl unit, and the number of carbon atoms at the terminal of a side chain of the carboxylic acid vinyl unit is 2-7.

公开(公告)号：US20190125555A1

公开(公告)日：2019-05-02

申请号：US16173879

申请日：2018-10-29

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82 ,  A61F2/06 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61L31/02 ,  A61L33/06 ,  A61L31/14 ,  A61L33/00

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.