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公开(公告)号：US10786606B2
公开(公告)日：2020-09-29
申请号：US15753266
申请日：2016-08-19
摘要： The present invention relates to the coating of a range of functional heparins onto the surface of a substrate for which hemocompatibility is a key functional characteristic, such that the functionality of the functional heparin is maintained. The approach employs a metal coordination complex to bind to the substrate with the functional heparin binding to the metal coordination complex to thereby impart hemocompatibility.
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公开(公告)号：US11202835B2
公开(公告)日：2021-12-21
申请号：US15777327
申请日：2016-11-21
IPC分类号： A61K47/61 , A61K47/54 , G01N30/06 , B01D15/38 , A61K47/59 , A61K31/496 , A61K38/16 , A61K39/395 , C07K16/18
摘要： The present invention relates to a method of controlled competitive exchange of a first agent bound to a metal coordination complex with a competing agent, with selection of the nature of the first agent allowing a tailoring of the binding strength and thereby allowing for a desired level of control for subsequent displacement by the selected competing agent. The method may be employed for release of therapeutic agents, sequestration of larger molecules from a sample, generation of a preferred binding surface and the like.
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公开(公告)号：US11726095B2
公开(公告)日：2023-08-15
申请号：US14907701
申请日：2014-08-13
IPC分类号： G01N33/58 , G01N33/543 , G01N33/553 , C07K17/14 , C07K1/13
CPC分类号： G01N33/587 , C07K1/13 , C07K17/14 , G01N33/54326 , G01N33/553
摘要： This invention resides in using metal complex-activated particles to bind molecules, polymers and other particles to each other, so as to produce multifunctional conjugates having controlled ratios of two or more different molecules.
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公开(公告)号：US20180333500A1
公开(公告)日：2018-11-22
申请号：US15777327
申请日：2016-11-21
IPC分类号： A61K47/61 , C07K16/18 , A61K47/54 , A61K47/59 , A61K38/16 , A61K39/395 , A61K31/496 , G01N30/06
CPC分类号： A61K47/61 , A61K31/496 , A61K38/16 , A61K39/3955 , A61K47/54 , A61K47/59 , C07K16/18 , G01N30/06
摘要： The present invention relates to a method of controlled competitive exchange of a first agent bound to a metal coordination complex with a competing agent, with selection of the nature of the first agent allowing a tailoring of the binding strength and thereby allowing for a desired level of control for subsequent displacement by the selected competing agent. The method may be employed for release of therapeutic agents, sequestration of larger molecules from a sample, generation of a preferred binding surface and the like.
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公开(公告)号：US10930925B2
公开(公告)日：2021-02-23
申请号：US16089594
申请日：2017-03-29
摘要： The invention relates to formulations comprising: (i) a first active material; (ii) a second active material; and (iii) a metal-coordination complex, wherein the first active material and the second active material have at least one surface property which is different, one from the other. Such formulations are more homogenous than those formed without the metal-coordination complex and can be used to form composite materials, such as those forming part of a conductive interface, having advantageous properties and providing for improvement in functionality of the conductive interface.
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公开(公告)号：US10586984B2
公开(公告)日：2020-03-10
申请号：US15567533
申请日：2016-04-19
IPC分类号： H01M4/58 , H01G11/46 , H01M4/38 , H01G11/32 , H01M4/36 , H01M4/505 , H01G11/42 , H01M4/62 , H01M4/525 , H01G11/30 , H01M4/583 , H01M10/42 , H01G4/008 , H01M10/052
摘要： The present invention describes the use of metal-ligand complexes within the active material of an electrode to provide for improvement in operation as well as to mitigate the cyclic stresses of swelling of the active material during charging and discharging operations and to provide resistance to dissolution of electrode active materials.
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公开(公告)号：US20160178636A1
公开(公告)日：2016-06-23
申请号：US14907701
申请日：2014-08-13
IPC分类号： G01N33/58 , G01N33/553 , G01N33/543
CPC分类号： G01N33/587 , C07K1/13 , C07K17/14 , G01N33/54326 , G01N33/553
摘要： This invention resides in using metal complex-activated particles to bind molecules, polymers and other particles to each other, so as to produce multifunctional conjugates having controlled ratios of two or more different molecules.
摘要翻译： 本发明在于使用金属络合物活化的颗粒将分子，聚合物和其它颗粒彼此结合，以便制备具有两个或多个不同分子的受控比例的多功能缀合物。
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