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    MATERIALS AND METHODS FOR IMMUNOASSAY OF PTERINS
    14.
    发明申请
    MATERIALS AND METHODS FOR IMMUNOASSAY OF PTERINS 审中-公开
    用于免疫杂交的材料和方法

    公开(公告)号：US20120115244A1

    公开(公告)日：2012-05-10

    申请号：US12942781

    申请日：2010-11-09

    申请人： Maciej Adamczyk ,  R. Jeffrey Brashear ,  Stephen C. Hsu ,  Phillip G. Mattingly

    发明人： Maciej Adamczyk ,  R. Jeffrey Brashear ,  Stephen C. Hsu ,  Phillip G. Mattingly

    IPC分类号： G01N33/53 ,  C07K14/765 ,  C07K2/00 ,  C07K14/435 ,  C07K16/00 ,  C07D475/04

    CPC分类号： C07D475/04 ,  C07D487/14 ,  C09B15/00 ,  G01N33/5308

    摘要： Methods of assaying for (i) a pterin by immunoassay employing a pterin as capture agent, (ii) neopterin by chemiluminescent microparticle immunoassay (CMIA) employing an anti-neopterin antibody (Ab) as capture agent, (iii) neopterin by an immunoassay (IA) employing an acridinium (Acr)-labeled anti-neopterin Ab as conjugate, and (iv) neopterin by an IA employing Acr-labeled neopterin as tracer; an Acr-labeled anti-neopterin Ab; a conjugate/complex comprising anti-neopterin Ab and a carrier scaffold; a conjugated pterin; a conjugate comprising an Acr-labeled pterin and a carrier scaffold; an immunogen comprising neopterin and a carrier protein; a conjugate comprising such an immunogen and an Acr compound; an immunogen comprising a carrier protein and a neopterin hapten; a conjugate comprising such an immunogen and an Acr compound; a kit for assaying a pterin comprising a pterin as a capture agent and instructions for IA; and a kit for assaying neopterin comprising an anti-neopterin Ab as a capture agent and instructions for CMIA, neopterin comprising an Acr-labeled anti-neopterin Ab as a conjugate and instructions for IA, or Acr-labeled neopterin as a tracer and instructions for IA.

    摘要翻译： 通过使用蝶呤作为捕获剂的免疫测定法测定（i）蝶呤的方法，（ii）使用抗新蝶呤抗体（Ab）作为捕获剂的化学发光微粒免疫测定（CMIA）的新蝶呤，（iii）通过免疫测定法 IA）使用吖啶（Acr）标记的抗新蝶呤Ab作为缀合物，和（iv）通过使用Acr标记的新蝶呤作为示踪剂的IA的新蝶呤; Acr标记的抗新蝶呤Ab; 包含抗新蝶呤Ab和载体支架的缀合物/复合物; 共轭蝶呤 包含Acr标记的蝶呤和载体支架的缀合物; 包含新蝶呤和载体蛋白的免疫原; 包含这种免疫原和Acr化合物的缀合物; 包含载体蛋白和新蝶呤半抗原的免疫原; 包含这种免疫原和Acr化合物的缀合物; 用于测定包含蝶呤作为捕获剂的蝶呤的试剂盒和用于IA的说明书; 以及用于测定新蝶呤的试剂盒，其包含抗新蝶呤Ab作为捕获剂和CMIA指令，包含Acr标记的抗新蝶呤Ab作为缀合物的新蝶呤，以及用于IA或Acr标记的新喋呤作为示踪剂的说明书 IA。

    Quinolinium ion derivatives, process for the production of the derivatives, products made by using the same, and reduction and oxidation methods with the derivatives
    17.
    发明授权
    Quinolinium ion derivatives, process for the production of the derivatives, products made by using the same, and reduction and oxidation methods with the derivatives 失效
    喹啉离子衍生物，制备衍生物的方法，使用该衍生物的产物，以及衍生物的还原和氧化方法

    公开(公告)号：US07977486B2

    公开(公告)日：2011-07-12

    申请号：US12440538

    申请日：2007-03-05

    申请人： Shunichi Fukuzumi ,  Hiroaki Kotani ,  Kei Ohkubo

    发明人： Shunichi Fukuzumi ,  Hiroaki Kotani ,  Kei Ohkubo

    IPC分类号： C07D215/04 ,  C07D213/22 ,  C07D213/56

    CPC分类号： C09B15/00 ,  C07D215/10 ,  C09B57/00 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029

    摘要： An electron donor-acceptor dyad is provided that can provide a charge-separated state with longevity and not only high oxidizing power but also high reducing power. A compound of the present invention is a quinolinium ion derivative represented by the following formula (I), a stereoisomer or tautomer thereof, or a salt thereof: where R1 is a hydrogen atom or an alkyl group, and Ar1 to Ar3 each are a hydrogen atom or an electron-donating group. The compound of the present invention has the above-mentioned structure and therefore can provide a charge-separated state with longevity and not only high oxidizing power but also high reducing power and can be used for various products such as photocatalysts, photosensitizers, dyes, oxidants, reductants, dye-sensitized solar cells, and organic EL devices.

    摘要翻译： 提供电子给体 - 受体二元体，其可以提供长寿命的电荷分离状态，不仅具有高氧化能力，而且还具有高还原能力。 本发明化合物是下式（I）表示的喹啉鎓离子衍生物，其立体异构体或互变异构体或其盐：其中，R 1为氢原子或烷基，Ar 1〜Ar 3为氢 原子或给电子基团。 本发明的化合物具有上述结构，因此可以提供具有寿命的电荷分离状态，不仅具有高的氧化能力，而且还具有高的还原能力，并且可用于各种产物如光催化剂，光敏剂，染料，氧化剂 ，还原剂，染料敏化太阳能电池和有机EL器件。

    Fluorescent Amino Acid Derivatives
    19.
    发明申请
    Fluorescent Amino Acid Derivatives 失效
    荧光氨基酸衍生物

    公开(公告)号：US20100152417A1

    公开(公告)日：2010-06-17

    申请号：US11916061

    申请日：2006-06-08

    申请人： Masumi Taki ,  Masahiko Sisido

    发明人： Masumi Taki ,  Masahiko Sisido

    IPC分类号： C07K2/00 ,  C07D221/18 ,  C07K14/00

    CPC分类号： C09B15/00 ,  C07K14/005 ,  C09B5/36 ,  C12N2740/16322 ,  Y02P20/55

    摘要： The subject of the present invention is to provide a fluorescent substance excitable under visible light, having higher photostability and a long fluorescence lifetime. Another subject is to provide a fluorescent substance consists of a non-natural amino acid applicable to peptide synthesis systems.Searching fluorescent substances, which are fluorescent amino acids and excitable under visible light, having the lowest possible molecular weight for a high photostability resulted in forming a condensed polycyclic aromatic compound by subjecting a compound having an acridone structure to substitution with an amino acid and further condensation with a benzene ring. Thus, the subject is achieved by the fluorescent substance consisting of amino acid-substituted benzoacridone derivative excitable under visible light.

    摘要翻译： 本发明的主题是提供在可见光下可激发的荧光物质，具有较高的光稳定性和较长的荧光寿命。 另一个主题是提供由适用于肽合成系统的非天然氨基酸组成的荧光物质。 在具有高光稳定性的情况下，以具有最低可能分子量的荧光氨基酸和可见光激发的荧光物质搜索导致通过使具有吖啶酮结构的化合物用氨基酸取代并进一步缩合形成稠合多环芳族化合物 与苯环。 因此，通过由可见光可激发的氨基酸取代的苯并吖啶酮衍生物构成的荧光物质来实现。