NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES
    1.
    发明申请
    NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES 审中-公开
    用于酶及其结合剂的新型超敏感发光基质

    公开(公告)号:US20100317122A1

    公开(公告)日:2010-12-16

    申请号:US12861400

    申请日:2010-08-23

    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent. an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.5

    Abstract translation: 新的化学发光化合物,在水性缓冲液中稳定,用于生物测定,包括吖啶类化合物和1,2-二氧杂环丁烷。 在新的吖啶类化合物中有水溶性吖啶,增强剂偶联的吖啶,双和三吖啶以及吖啶-1,3-二恶烷。 在新的1,2-二氧杂环丁烷中,含有电子缺乏基团的二氧杂环丁烷和连接的双-1,2-二氧杂环丁烷。 1,2-二氧杂环丁烷可用作各种酶的底物。 吖啶可与氧化剂混合。 水性缓冲液和任选的稳定剂,以形成用于特别测定HRP的底物或试剂制剂

    NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES
    6.
    发明申请
    NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES 审中-公开
    用于酶及其结合剂的新型超敏感发光基质

    公开(公告)号:US20140073771A1

    公开(公告)日:2014-03-13

    申请号:US14026160

    申请日:2013-09-13

    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent. an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.

    Abstract translation: 新的化学发光化合物,在水性缓冲液中稳定,用于生物测定,包括吖啶类化合物和1,2-二氧杂环丁烷。 在新的吖啶类化合物中有水溶性吖啶,增强剂偶联的吖啶,双和三吖啶以及吖啶-1,3-二恶烷。 在新的1,2-二氧杂环丁烷中,含有电子缺乏基团的二氧杂环丁烷和连接的双-1,2-二氧杂环丁烷。 1,2-二氧杂环丁烷可用作各种酶的底物。 吖啶可与氧化剂混合。 水性缓冲液和任选的稳定剂,以形成用于特别测定HRP的底物或试剂制剂。

    Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates
    7.
    发明授权
    Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates 失效
    用于酶及其共轭物的超敏感化学发光底物

    公开(公告)号:US08546150B2

    公开(公告)日:2013-10-01

    申请号:US12861492

    申请日:2010-08-23

    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.

    Abstract translation: 新的化学发光化合物,在水性缓冲液中稳定,用于生物测定,包括吖啶类化合物和1,2-二氧杂环丁烷。 在新的吖啶类化合物中有水溶性吖啶,增强剂偶联的吖啶,双和三吖啶以及吖啶-1,3-二恶烷。 在新的1,2-二氧杂环丁烷中,含有电子缺乏基团的二氧杂环丁烷和连接的双-1,2-二氧杂环丁烷。 1,2-二氧杂环丁烷可用作各种酶的底物。 吖啶可以与氧化剂混合,含水缓冲液和任选的稳定剂,以形成用于特别是用于测定HRP的底物或试剂制剂。

    ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES
    8.
    发明申请
    ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES 有权
    用于酶及其结合剂的超敏感性发光基质

    公开(公告)号:US20100317877A1

    公开(公告)日:2010-12-16

    申请号:US12861453

    申请日:2010-08-23

    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent. an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.

    Abstract translation: 新的化学发光化合物,在水性缓冲液中稳定,用于生物测定,包括吖啶类化合物和1,2-二氧杂环丁烷。 在新的吖啶类化合物中有水溶性吖啶,增强剂偶联的吖啶,双和三吖啶以及吖啶-1,3-二恶烷。 在新的1,2-二氧杂环丁烷中,含有电子缺乏基团的二氧杂环丁烷和连接的双-1,2-二氧杂环丁烷。 1,2-二氧杂环丁烷可用作各种酶的底物。 吖啶可与氧化剂混合。 水性缓冲液和任选的稳定剂,以形成用于特别测定HRP的底物或试剂制剂。

    ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES
    9.
    发明申请
    ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES 失效
    用于酶及其结合剂的超敏感性发光基质

    公开(公告)号:US20100317031A1

    公开(公告)日:2010-12-16

    申请号:US12861492

    申请日:2010-08-23

    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.

    Abstract translation: 新的化学发光化合物,在水性缓冲液中稳定,用于生物测定,包括吖啶类化合物和1,2-二氧杂环丁烷。 在新的吖啶类化合物中有水溶性吖啶,增强剂偶联的吖啶,双和三吖啶以及吖啶-1,3-二恶烷。 在新的1,2-二氧杂环丁烷中,含有电子缺乏基团的二氧杂环丁烷和连接的双-1,2-二氧杂环丁烷。 1,2-二氧杂环丁烷可用作各种酶的底物。 吖啶可以与氧化剂混合,含水缓冲液和任选的稳定剂,以形成用于特别是用于测定HRP的底物或试剂制剂。

    Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates
    10.
    发明授权
    Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates 有权
    用于酶及其共轭物的超敏感化学发光底物

    公开(公告)号:US07781229B2

    公开(公告)日:2010-08-24

    申请号:US11578601

    申请日:2005-04-14

    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridanebased compounds and (1,2)-dioxetanes. Among the new acridanebased compounds are water-soluble acridanes, enhancer coupled acridanes, bis and trisacridanes as well as acridane-(1,2)-dioxetanes. Among the new (1,2)-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The (1,2)-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent. An aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.

    Abstract translation: 在水性缓冲液中稳定的用于生物测定的新化学发光化合物包括吖啶基化合物和(1,2) - 二氧杂环丁烷。 在新的吖啶系化合物中有水溶性吖啶,增强剂偶联吖啶,双和三吖啶以及吖啶 - (1,2) - 二氧杂环丁烷。 新的(1,2) - 二氧杂环丁烷是含有电子缺乏基团的二氧杂环丁烷和连接的双-1,2-二氧杂环丁烷。 (1,2) - 二氧杂环己烷可用作各种酶的底物。 吖啶可与氧化剂混合。 水性缓冲液和任选的稳定剂,以形成用于特别测定HRP的底物或试剂制剂。

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