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    Biocompatible phase invertible proteinaceous compositions and methods for making and using the same
    12.
    发明授权
    Biocompatible phase invertible proteinaceous compositions and methods for making and using the same 有权
    生物相容相可逆蛋白质组合物及其制备和使用方法

    公开(公告)号：US08198363B2

    公开(公告)日：2012-06-12

    申请号：US12326835

    申请日：2008-12-02

    Applicant: Ronald Dieck ,  Ian J. Handley ,  Neil Winterbottom ,  Joanna Wong

    Inventor： Ronald Dieck ,  Ian J. Handley ,  Neil Winterbottom ,  Joanna Wong

    IPC: A61K47/48

    CPC classification number: A61L24/108 ,  A61L24/043 ,  A61L24/10 ,  A61L31/041 ,  C08L89/00 ,  C08L5/08

    Abstract: Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

    Abstract translation: 提供生物相容相可逆蛋白质组合物及其制备和使用方法。 根据本发明的相可逆组合物通过组合液体蛋白质基质和液体交联组合物制备，其中液体交联组合物包含大分子交联剂。 还提供了用于制备主题组合物的试剂盒。 主题组合物，试剂盒和系统可用于各种不同的应用。

    PROCESS FOR MAKING DRY AND STABLE HEMOSTATIC COMPOSITIONS
    13.
    发明申请
    PROCESS FOR MAKING DRY AND STABLE HEMOSTATIC COMPOSITIONS 有权
    制备干燥和稳定的HEMOSTATIC组合物的方法

    公开(公告)号：US20120121532A1

    公开(公告)日：2012-05-17

    申请号：US13151048

    申请日：2011-06-01

    Applicant: Andreas Goessl ,  Atsushi Edward Osawa ,  Cary J. Reich

    Inventor： Andreas Goessl ,  Atsushi Edward Osawa ,  Cary J. Reich

    IPC: A61K38/48 ,  A61P7/04 ,  A61K31/765 ,  B32B1/02 ,  A61K31/78 ,  A61K31/785

    CPC classification number: A61L24/043 ,  A61K9/0014 ,  A61K9/1658 ,  A61K9/19 ,  A61K38/39 ,  A61K38/4833 ,  A61L24/0015 ,  A61L24/10 ,  A61L24/106 ,  A61L2300/418 ,  A61L2300/802 ,  A61L2400/04 ,  A61L2400/06 ,  B65B3/003 ,  B65B5/12 ,  B65B55/02 ,  C12Y304/21005 ,  Y10T428/13

    Abstract: Described is a process for making a dry and stable hemostatic composition, said process comprisinga) providing a first component comprising a dry preparation of a coagulation inducing agent,b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) providing said first component and said second component in a combined form in a final container, c1) either by filling said first component and said second component into said final container so as to obtain a dry mixture in said final container, c2) or by providing said first component or said second component in said final container and adding said second component or said first component so as to obtain a combination of said first component with said second component in said final container, d) finishing the final container to. a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.

    Abstract translation: 描述了制备干燥和稳定的止血组合物的方法，所述方法包括a）提供包含凝结诱导剂的干制剂的第一组分，b）提供第二组分，其包含适于用于 止血，c）以最终容器中的组合形式提供所述第一组分和所述第二组分，c1）通过将所述第一组分和所述第二组分填充到所述最终容器中以便在所述最终容器中获得干混合物，c2 ）或通过在所述最终容器中提供所述第一组分或所述第二组分并加入所述第二组分或所述第一组分以获得所述第一组分与所述最终容器中的所述第二组分的组合，d）将最终容器整理成 。 包含所述第一组分和所述第二组分的可储存药物装置，其为组合形式，作为干燥且稳定的止血组合物。

    REINFORCED ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF
    14.
    发明申请
    REINFORCED ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF 审中-公开
    增强粘合复合材料及其制备和使用方法

    公开(公告)号：US20110287067A1

    公开(公告)日：2011-11-24

    申请号：US13114397

    申请日：2011-05-24

    Applicant: Russell John STEWART

    Inventor： Russell John STEWART

    IPC: A61K9/00 ,  A61K38/18 ,  A61P19/08 ,  A61P27/02 ,  A61P37/02 ,  A61B17/03 ,  A61P31/00 ,  A61P5/00 ,  C07K2/00 ,  C08B37/00 ,  B01J41/12 ,  A61K31/7088 ,  A61P29/00

    CPC classification number: A61L24/046 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/043 ,  A61L24/06 ,  A61L24/10 ,  A61L27/26 ,  A61L27/54 ,  A61L2300/62 ,  A61L2430/16 ,  C08F8/00 ,  C08F8/06 ,  C08L89/00

    Abstract: Described herein is the synthesis of reinforced adhesive complex coacervates and their use thereof. The reinforced adhesive complex coacervates are composed of (a) at least one polycation, (b) at least one polyanion, and (c) a reinforcing component. The adhesive complex coacervates described herein can be subsequently cured to produce strong, cohesive adhesives. The reinforced adhesive complex coacervates have several desirable features when compared to conventional adhesives. The reinforced adhesive complex coacervates are effective in wet or underwater applications. The reinforced adhesive complex coacervates described herein, being phase separated from water, can be applied underwater without dissolving or dispersing into the water. The reinforced adhesive complex coacervates have numerous biological applications as bioadhesives and bioactive delivery devices. In particular, the reinforced adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, wet tissues in physiological conditions.

    Abstract translation: 本文描述的是增强粘合剂复合凝聚层的合成及其用途。 增强粘合剂复合物凝聚层由（a）至少一种聚阳离子，（b）至少一种聚阴离子和（c）增强组分组成。 随后可以固化本文所述的粘合剂复合物凝聚层以产生强的粘结粘合剂。 当与常规粘合剂相比时，增强粘合剂复合物凝聚层具有几个期望的特征。 增强粘合剂复合物凝聚层在湿法或水下应用中是有效的。 本文所述的与水相分离的增强粘合剂复合物凝聚层可以在水中施加而不溶解或分散在水中。 增强粘合剂复合物凝聚层具有生物粘合剂和生物活性递送装置的许多生物应用。 特别地，本文所述的增强粘合剂复合物凝聚层在水下应用和存在水的情况下特别有用，例如生理条件下的湿纸巾。

    Enzyme inhibiting adhesives
    16.
    发明授权
    Enzyme inhibiting adhesives 有权
    酶抑制粘合剂

    公开(公告)号：US07858836B2

    公开(公告)日：2010-12-28

    申请号：US11288610

    申请日：2005-11-29

    Applicant: Mahesh Sambasivam

    Inventor： Mahesh Sambasivam

    IPC: A61F13/00 ,  C08L3/02

    CPC classification number: A61K36/81 ,  A61L15/40 ,  A61L15/58 ,  A61L15/60 ,  A61L24/0015 ,  A61L24/10 ,  A61L2300/434

    Abstract: An adhesive composition including an adhesive component and an enzyme inhibiting component for use in ostomy and wound care applications. The enzyme inhibitors are derived from tubers, such as potatoes. In ostomy, the adhesive composition helps to secure the collection bag or pouch to the skin. In wound care application, the adhesive composition secures the wound dressing to the skin. The adhesive composition also may be used to couple two or more ostomy or wound care components together.

    Abstract translation: 一种粘合剂组合物，包括用于造口和伤口护理应用的粘合剂组分和酶抑制组分。 酶抑制剂衍生自块茎，如马铃薯。 在造口术中，粘合剂组合物有助于将收集袋或小袋固定到皮肤上。 在伤口护理应用中，粘合剂组合物将伤口敷料固定到皮肤上。 粘合剂组合物还可用于将两个或多个造口或伤口护理部件连接在一起。

    BIOGEL
    17.
    发明申请
    BIOGEL 有权

    公开(公告)号：US20100249044A1

    公开(公告)日：2010-09-30

    申请号：US12515721

    申请日：2007-11-27

    Applicant: Greg Walker

    Inventor： Greg Walker

    IPC: A61K38/36 ,  C12N5/07 ,  A61P17/02

    CPC classification number: A61K38/07 ,  A61K9/0014 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L24/10 ,  A61L24/106 ,  A61L2400/04

    Abstract: A biogel, and kits, agents, and methods for formation of the biogel are described. The biogel can be used for a variety of applications, including haemostasis, wound sealing, tissue engineering or localised drug delivery.

    Abstract translation: 描述了生物凝胶，以及用于形成生物凝胶的试剂盒，试剂和方法。 生物凝胶可用于各种应用，包括止血，伤口密封，组织工程或局部药物递送。

    Method for attaching two surfaces to each other using a bioadhesive polyphenolic protein and periodate ions
    18.
    发明申请
    Method for attaching two surfaces to each other using a bioadhesive polyphenolic protein and periodate ions 有权

    公开(公告)号：US20070160744A1

    公开(公告)日：2007-07-12

    申请号：US11637011

    申请日：2006-12-12

    Applicant: Magnus Qvist

    Inventor： Magnus Qvist

    IPC: A61K38/16

    CPC classification number: A61L27/34 ,  A61L24/10 ,  C09D189/00 ,  C09J5/00 ,  C09J189/00 ,  C08L89/00

    Abstract: The present invention pertains to a method for attaching two surfaces to each other or coating a surface by providing a bioadhesive composition consisting of an aqueous solution of a bioadhesive polyphenolic protein derived from a byssus-forming mussel, and mixing said bioadhesive composition with a preparation comprising non-enzymatic oxidising periodate ions so that the concentration of periodate ions is at least 1.80 mmol/g in the final composition before applying the mixture to at least one of two surfaces to be attached to each other or coated or applying said composition and said periodate ions without any specific order, to at least one of two surfaces to be attached to each other or the surface to be coated, thereby mixing the bioadhesive composition and the periodate ions. The surfaces are then joined (if necessary) and left for sufficiently long time for curing to occur. The invention can be provided as a kit of parts comprising the MAP-solution, a preparation comprising the periodate ions and optionally a device to apply the compositions of the invention to surfaces that are to be attached to each other or coated.

    Method for attaching two surfaces to each other using a bioadhesive polyphenolic protein and periodate ions
    19.
    发明申请
    Method for attaching two surfaces to each other using a bioadhesive polyphenolic protein and periodate ions 有权
    使用生物粘附性多酚蛋白和高碘酸盐离子将两个表面彼此连接的方法

    公开(公告)号：US20050224175A1

    公开(公告)日：2005-10-13

    申请号：US10509401

    申请日：2003-03-25

    Applicant: Magnus Qvist

    Inventor： Magnus Qvist

    IPC: A61L24/10 ,  A61L27/34 ,  C09D189/00 ,  C09J5/00 ,  C09J189/00 ,  B32B31/00

    CPC classification number: A61L27/34 ,  A61L24/10 ,  C09D189/00 ,  C09J5/00 ,  C09J189/00 ,  C08L89/00

    Abstract: The present invention pertains to a method for attaching two surfaces to each other or coating a surface by providing a bioadhesive composition consisting of an aqueous solution of a bioadhesive polyphenolic protein derived from a byssus-forming mussel, and mixing said bioadhesive composition with a preparation comprising non-enzymatic oxidising periodate ions so that the concentration of periodate ions is at least 1.80 mmol/g in the final composition before applying the mixture to at least one of two surfaces to be attached to each other or coated or applying said composition and said periodate ions without any specific order, to at least one of two surfaces to be attached to each other or the surface to be coated, thereby mixing the bioadhesive composition and the periodate ions. The surfaces are then joined (if necessary) and left for sufficiently long time for curing to occur. The invention can be provided as a kit of parts comprising the MAP-solution, a preparation comprising the periodate ions and optionally a device to apply the compositions of the invention to surfaces that are to be attached to each other or coated.

    Abstract translation: 本发明涉及通过提供一种生物粘合剂组合物将两个表面彼此附着或涂覆在一起的方法，所述生物粘合剂组合物由衍生自构成贻贝的生物粘附多酚蛋白的水溶液组成，并将所述生物粘附性组合物与包含 非酶促氧化高碘酸盐离子，使得最终组合物中高碘酸根离子的浓度至少为1.80mmol / g，然后将所述混合物施用于要彼此连接的两个表面中的至少一个或涂覆或施用所述组合物和所述高碘酸盐 离子没有任何特定的顺序，至少要彼此连接的两个表面或待涂覆的表面中，从而混合生物粘合剂组合物和高碘酸盐离子。 然后将表面连接（如果需要）并且留下足够长的时间以进行固化发生。 本发明可以作为包含MAP-溶液，包含高碘酸根离子的制剂和任选的将本发明组合物施用于彼此连接或涂覆的表面的装置的试剂盒来提供。

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