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公开(公告)号：US10401332B2
公开(公告)日：2019-09-03
申请号：US15062405
申请日：2016-03-07
摘要： A system and method of reducing chromatographic band broadening within a separation column include passing a mobile phase through a length of a separation column, and generating a spatial thermal gradient external to and along the length of the separation column. The spatial thermal gradient is specifically configured to counteract a particular change in a property of the mobile phase as the mobile phase passes through the separation column. For example, the particular change counteracted may be a change in density or in temperature of the mobile phase. For analytical-scale columns, for example, the spatial thermal gradient may be configured to produce temperatures external to and along the length of the separation column that substantially matches temperatures predicted to form in the mobile phase along the column length as the mobile phase passes through the separation column, thereby substantially preventing formation of a radial thermal gradient in the mobile phase.
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12.发明申请公开(公告)号：US20160266077A1
公开(公告)日：2016-09-15
申请号：US15062430
申请日：2016-03-07
IPC分类号： G01N30/30
CPC分类号： G01N30/30 , G01N2030/3015 , G01N2030/303 , G01N2030/3053
摘要： Analytical-scale separation column assemblies include a tube with a bore packed with a stationary phase through which a mobile phase flows. In one embodiment, thermal elements are disposed remotely from and unattached to the tube. The thermal elements are in thermal communication with an external surface of the tube for producing a spatial thermal gradient outside of and along a length of the tube. In another embodiment, discrete, spatially separated strips of thermally conductive material are disposed on and wrapped around an external surface of the tube. Thermal elements are disposed remotely from the tube. Each thermal element is in thermal communication with one strip of thermally conductive material by a heat-transfer device. The thermal elements produce a spatial thermal gradient outside of and along a tube length by controlling temperature of each strip of thermally conductive material disposed on and wrapped around the external surface of the tube.
摘要翻译： 分析级分离柱组件包括具有填充有流动相流过的固定相的孔的管。 在一个实施例中，热元件远离管并且不附接于管。 热元件与管的外表面热连通，用于在管的长度之外和沿着管的长度产生空间热梯度。 在另一个实施例中，离散的，空间上分离的导热材料条被布置在管的外表面上并且缠绕在管的外表面上。 热元件远离管放置。 每个热元件通过热传递装置与一条导热材料热连通。 热元件通过控制设置在管的外表面上并缠绕在管的外表面上的每个导热材料条的温度在管长度之外产生空间热梯度。
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13.发明申请SYSTEM AND METHOD FOR REDUCING CHROMATOGRAPHIC BAND BROADENING IN SEPARATION DEVICES 审中-公开用于降低分离装置中色谱条带宽度的系统和方法公开(公告)号：US20160266076A1
公开(公告)日：2016-09-15
申请号：US15062405
申请日：2016-03-07
CPC分类号： G01N30/30 , B01D15/16 , B01D15/161 , B01D15/40 , G01N30/02 , G01N30/54 , G01N2030/027 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N2030/3053 , H01L33/645
摘要： A system and method of reducing chromatographic band broadening within a separation column include passing a mobile phase through a length of a separation column, and generating a spatial thermal gradient external to and along the length of the separation column. The spatial thermal gradient is specifically configured to counteract a particular change in a property of the mobile phase as the mobile phase passes through the separation column. For example, the particular change counteracted may be a change in density or in temperature of the mobile phase. For analytical-scale columns, for example, the spatial thermal gradient may be configured to produce temperatures external to and along the length of the separation column that substantially matches temperatures predicted to form in the mobile phase along the column length as the mobile phase passes through the separation column, thereby substantially preventing formation of a radial thermal gradient in the mobile phase.
摘要翻译： 在分离塔内减少色谱带宽增长的系统和方法包括使流动相通过一段分离柱，并产生沿着分离柱外部和沿着分离柱长度的空间热梯度。 空间热梯度被特别配置为当流动相通过分离柱时抵消流动相的特性变化。 例如，抵消的特定变化可以是流动相的密度或温度的变化。 对于分析级列，例如，空间热梯度可以被配置为产生在分离柱的长度之外和沿着分离柱的长度，其基本上与流动相通过时沿柱长度预测形成的温度相匹配 分离柱，从而基本上防止在流动相中形成径向热梯度。
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公开(公告)号：US11041834B2
公开(公告)日：2021-06-22
申请号：US16292610
申请日：2019-03-05
摘要： A chromatographic device includes a primary channel having a cross-sectional area and characteristic length such that analyte travel within the primary channel is substantially convective. A plurality of secondary channels each having a cross-sectional area and characteristic length such that analyte flow into and out of a secondary channel is substantially diffusive, each of the plurality of secondary channels having an entrance in fluidic communication with the primary channel wherein the entrance intersects the primary channel.
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15.发明申请公开(公告)号：US20200217825A1
公开(公告)日：2020-07-09
申请号：US16334118
申请日：2017-09-13
摘要： Methods for transferring a carbon dioxide based separation procedure from a first chromatographic system to a second one involve identifying an average column pressure for the separation in the first system is identified, determining a measured average column pressure for the separation in the second system, and comparing the measured average column pressure with the identified average column pressures. To more closely match the identified average column pressure, the methods involve: (a) altering a cross-sectional area of a column packed with media in the second system; and/or (b) adding makeup fluid along the length of the column in the second system. Columns with the characteristics used in the methods and second chromatographic systems are disclosed.
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公开(公告)号：US10705060B2
公开(公告)日：2020-07-07
申请号：US15553268
申请日：2016-02-25
摘要： Methods for focusing analyte peaks in liquid chromatography using a spatial temperature gradient are provided. Also provided are methods for focusing analyte peaks and improving resolution using a trap column upstream of a separation column. Further, methods are provided in which the trap column placed upstream of the separation column is packed with a temperature-sensitive polymer/copolymer, and a spatial temperature gradient is applied along the trap column for obtaining improved retentivity by trap column stationary phase, and overall improved resolution of analyte peaks.
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公开(公告)号：US10359403B2
公开(公告)日：2019-07-23
申请号：US15909275
申请日：2018-03-01
发明人： Michael O. Fogwill , Joshua A. Shreve , Michael Eggertson , Thomas S. McDonald , Joseph D. Michienzi , Abhijit Tarafder
摘要： The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO2-based chromatography system. A first pressure control element is located downstream of a CO2-based chromatography system and is disposed to control pressure within the column. A split restrictor is located downstream of the primary pressure control element and is disposed to divert a portion of the mobile phase flow to a detector. A second pressure control element is located downstream of the split restrictor and is disposed to control pressure at the restrictor. While the first pressure control element executes a pressure-controlled gradient separation, the second pressure control element maintains a constant pressure at the restrictor. During a composition-programmed gradient separation, the second control element maintains a constant pressure at the split restrictor while the first pressure control element maintains a constant average density across the column.
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公开(公告)号：US20190187109A1
公开(公告)日：2019-06-20
申请号：US16223330
申请日：2018-12-18
CPC分类号： G01N30/14 , B01D15/18 , B01D15/26 , G01N1/34 , G01N30/32 , G01N30/34 , G01N2030/143 , G01N2030/342
摘要： In various aspects provided are purification media and containers for dispensing a purified liquid are provided herein where a high surface area-to-volume chemically interactive purification media positioned at the outlet of a container that purifies the liquid as it is dispensed and/or extracted.
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19.发明申请公开(公告)号：US20190083901A1
公开(公告)日：2019-03-21
申请号：US16070908
申请日：2017-01-19
摘要： In a sample extraction system, providing within the system two or more extraction vessel assemblies, each of which receive an extraction vessel containing the sample to be extracted and is pressurized with an extraction solvent. Additionally, providing certain changeable fluid circuits such that the extraction system may provide a sustained delivery of feed solution above or about a threshold concentration.
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公开(公告)号：US20180306757A1
公开(公告)日：2018-10-25
申请号：US15769215
申请日：2016-10-19
发明人： Abhijit Tarafder
CPC分类号： G01N30/06 , G01N30/20 , G01N30/88 , G01N2030/207
摘要： A significant reduction in extra-column band broadening can be achieved by decoupling the injection system from the main solvent flow line. In addition, by decoupling the injection system from the main solvent flow line, additional components (e.g., filters, valves, etc.) can be introduced into the chromatography system without increasing the negative band broadening effects. Systems and methods herein provide not only for such decoupling but also for filtering precipitates from the system. As a result, a larger volume of sample can be injected into the present systems without compromising separation yield. In addition, an increase the column loading per batch, an increase the overall yield of separations, and greater system efficiency (i.e., less time lost for cleaning and maintenance) can be realized.
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