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    Cannulated Device with Atraumatic Tip for Delivering Local Depot to a Joint Space and Methods of Use Thereof
    11.
    发明申请
    Cannulated Device with Atraumatic Tip for Delivering Local Depot to a Joint Space and Methods of Use Thereof 审中-公开
    具有无创尖端的插管装置，用于将本地仓库交付给关节空间及其使用方法

    公开(公告)号：US20090287165A1

    公开(公告)日：2009-11-19

    申请号：US12120819

    申请日：2008-05-15

    Applicant: Susan Drapeau ,  Nelson Scarborough

    Inventor： Susan Drapeau ,  Nelson Scarborough

    IPC: A61M25/00

    CPC classification number: A61B17/3421 ,  A61B17/3439 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2017/3447 ,  A61B2017/3456 ,  A61B2017/3488

    Abstract: Devices for delivery of a pharmaceutical depot is provided. Exemplary device may comprise a cannula defining a working channel between a distal end and a proximal end, wherein the distal end comprises an atraumatic tip. The atraumatic tip may comprise a rounded tip or a soft tip. The cannulated delivery device may include a docking member proximally adjacent to the distal end of the lumen. Methods of using such devices to deliver pharmaceutical depot into a joint space are also provided.

    Abstract translation: 提供用于递送药剂库的设备。 示例性装置可以包括在远端和近端之间限定工作通道的套管，其中远端包括无创伤的尖端。 无创尖端可以包括圆形尖端或软尖端。 插管输送装置可以包括靠近内腔远端的对接构件。 还提供了使用这种装置将药剂库输送到关节空间中的方法。

    Methods, systems and reagents for tendon and ligament therapy
    12.
    发明申请
    Methods, systems and reagents for tendon and ligament therapy 审中-公开
    用于腱和韧带治疗的方法，系统和试剂

    公开(公告)号：US20070259030A1

    公开(公告)日：2007-11-08

    申请号：US11418948

    申请日：2006-05-05

    Applicant: Susan Drapeau

    Inventor： Susan Drapeau

    IPC: A61K38/55 ,  A61K9/127

    CPC classification number: A61L27/54 ,  A61K38/57 ,  A61L2300/222 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/434 ,  A61L2300/802

    Abstract: A method for the use and delivery of tissue inhibitors of matrix metalloproteinase (TIMPs) to control the activity of the matrix metalloproteinase (MMPs) in the extracellular matrix (ECM) in order to treat and prevent extracellular matrix degradation in an injured tendon or ligament is presented. Accelerated breakdown of the extracellular matrix occurs in various pathological processes, including inflammation, chronic degenerative diseases and tumor invasion. Four members of the tissue inhibitor of metalloproteinase (TIMP) family have been characterized so far, designated as TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Various introduction amounts, timing and combinations are capable of inhibiting the activities of all known matrix metalloproteinase (MMPs) and as such play a key role in maintaining the balance between (ECM) deposition and degradation in different physiological processes.

    Abstract translation: 使用和传递基质金属蛋白酶（TIMPs）的组织抑制剂以控制细胞外基质（ECM）中的基质金属蛋白酶（MMP）的活性以便治疗和预防损伤的肌腱或韧带中的细胞外基质降解的方法是 呈现。 细胞外基质的加速分解发生在各种病理过程中，包括炎症，慢性退行性疾病和肿瘤侵袭。 金属蛋白酶组织抑制剂（TIMP）家族的四个成员迄今已被表征为TIMP-1，TIMP-2，TIMP-3和TIMP-4。 各种引入量，时间和组合都能够抑制所有已知的基质金属蛋白酶（MMP）的活性，因此在保持不同生理过程中（ECM）沉积和降解之间的平衡方面起关键作用。

    Pharmaceutical removal of vascular extensions from a degenerating disc
    13.
    发明申请
    Pharmaceutical removal of vascular extensions from a degenerating disc 审中-公开
    药物从退化椎间盘移除血管延伸

    公开(公告)号：US20070253960A1

    公开(公告)日：2007-11-01

    申请号：US11413346

    申请日：2006-04-28

    Applicant: Josee Roy ,  Susan Drapeau ,  Jeffrey Marx

    Inventor： Josee Roy ,  Susan Drapeau ,  Jeffrey Marx

    IPC: A61K39/395

    CPC classification number: A61K31/16 ,  A61K31/337 ,  A61K31/573 ,  A61K38/179 ,  A61K38/18 ,  A61K2039/505

    Abstract: The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disc includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disc. Disruption of vascular elements includes causing the vascular extensions to retract from the disc, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.

    Abstract translation: 本发明提供了一种通过施用破坏椎间盘中的神经元和/或血管元件（通常是退化的椎间盘）的治疗剂来减轻椎间盘突出症的方法。 盘中的神经元元件的破坏包括破坏神经末梢而基本上不影响神经的中枢体，抑制神经末梢的激活，并抑制神经末梢进入椎间盘的生长。 血管元件的破坏包括使血管延伸部从椎间盘缩回，或抑制这种延伸的形成。 治疗剂可以通过体内泵，推注或贮库局部给药，或者可以全身给药。

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