公开(公告)号：US20140031330A1

公开(公告)日：2014-01-30

申请号：US13939962

申请日：2013-07-11

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Benjamin Fauber ,  Simon Gaines ,  Alberto Gobbi ,  Olivier Rene ,  David Vesey ,  Stuart Ward

IPC: C07D487/04 ,  C07D417/12 ,  C07D471/04 ,  C07D295/185

CPC classification number: C07D295/185 ,  C07D275/02 ,  C07D279/02 ,  C07D281/02 ,  C07D291/02 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D451/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/10 ,  C07D498/10 ,  C07D513/10 ,  C07D515/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n，p，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6 ，R7，R8，R9，R10，R11和R12如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US11008312B2

公开(公告)日：2021-05-18

申请号：US16398795

申请日：2019-04-30

Applicant: Genentech, Inc.

Inventor： Sarah M. Bronner ,  James J. Crawford ,  Andrew Cridland ,  Patrick Cyr ,  Benjamin Fauber ,  Emanuela Gancia ,  Alberto Gobbi ,  Christopher Hurley ,  Jonathan Killen ,  Wendy Lee ,  Olivier Rene ,  Monique Bodil Van Niel ,  Stuart Ward ,  Paul Winship ,  Jason Zbieg

IPC: C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D401/14

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20160311817A1

公开(公告)日：2016-10-27

申请号：US15202911

申请日：2016-07-06

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Olivier Rene ,  Sushant Malhotra ,  Herbert Yajima

IPC: C07D417/14 ,  C07D417/04

CPC classification number: C07D417/14 ,  C07D417/04 ,  C07D417/10

Abstract: Compounds of the formula I or a pharmaceutical salt thereof, wherein m, n, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 或其药物盐，其中m，n，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10 和R 11如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US20160272631A1

公开(公告)日：2016-09-22

申请号：US14481991

申请日：2014-09-10

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Alberto Gobbi

IPC: C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Compounds of the formula I or II: or pharmaceutically acceptable salts thereof, wherein R1 is a group of formula (a), (b), (c); (d) or (e): and m, n, X, Y, R1, R2, R3, R4, Rb and Rc are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 并且m，n，X，Y，R 1，R 2，R 3，R 4，R b和R c如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US09115101B2

公开(公告)日：2015-08-25

申请号：US13939962

申请日：2013-07-11

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Benjamin Fauber ,  Simon Gaines ,  Alberto Gobbi ,  Olivier Rene ,  David Vesey ,  Stuart Ward

IPC: C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D279/02 ,  C07D281/02 ,  C07D291/02 ,  C07D295/185 ,  C07D491/10 ,  C07D513/10 ,  A61K31/541 ,  A61P19/02 ,  C07D451/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D275/02 ,  C07D498/10 ,  C07D515/12

CPC classification number: C07D295/185 ,  C07D275/02 ,  C07D279/02 ,  C07D281/02 ,  C07D291/02 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D451/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/10 ,  C07D498/10 ,  C07D513/10 ,  C07D515/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n，p，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6 ，R7，R8，R9，R10，R11和R12如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US20150197529A1

公开(公告)日：2015-07-16

申请号：US14593260

申请日：2015-01-09

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Alberto Gobbi ,  Olivier Rene ,  Monique Bodil van Niel ,  Emanuela Gancia ,  Simon Gaines ,  Tammy Laddywahetty ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC: C07D491/113 ,  C07D491/107 ,  C07D417/12 ,  C07D417/14 ,  C07D279/02

CPC classification number: C07D417/10 ,  C07D279/02 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/107 ,  C07D491/113

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n，p，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6 ，R7，R8，R9，R10，R11和R12如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US20150105429A1

公开(公告)日：2015-04-16

申请号：US14574972

申请日：2014-12-18

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Olivier Rene

IPC: C07D413/04 ,  C07D231/12 ,  C07C311/16 ,  C07D409/04 ,  C07D213/42 ,  C07D333/22 ,  C07D409/12 ,  C07C317/32 ,  C07C311/13

CPC classification number: C07D413/04 ,  C07C311/13 ,  C07C311/16 ,  C07C311/37 ,  C07C317/32 ,  C07C317/48 ,  C07D213/42 ,  C07D231/12 ,  C07D277/28 ,  C07D333/20 ,  C07D333/22 ,  C07D333/24 ,  C07D409/04 ,  C07D409/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, A, B, C, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式I化合物或其药学上可接受的盐，其中m，A，B，C，R 1，R 2，R 3，R 4和R 5如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US20180222882A1

公开(公告)日：2018-08-09

申请号：US15801201

申请日：2017-11-01

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Monique Bodil van Niel ,  Andrew Cridland ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward

IPC: C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  C07D401/14 ,  C07D491/107 ,  A61P19/02 ,  A61P25/28 ,  A61P17/06 ,  A61P1/00 ,  A61P11/00 ,  A61P11/06

CPC classification number: C07D401/04 ,  A61P1/00 ,  A61P11/00 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D491/107

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, A, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US09751873B2

公开(公告)日：2017-09-05

申请号：US15047523

申请日：2016-02-18

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Alberto Gobbi ,  Olivier Rene ,  Monique Bodil van Niel ,  Emanuela Gancia ,  Simon Gaines ,  Tammy Ladduwahetty ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC: C07D417/14 ,  C07D417/10 ,  C07D279/02 ,  C07D417/12 ,  C07D491/107 ,  C07D491/113 ,  C07D487/08

CPC classification number: C07D417/10 ,  C07D279/02 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/107 ,  C07D491/113

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20170137393A1

公开(公告)日：2017-05-18

申请号：US15199447

申请日：2016-06-30

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Benjamin Fauber ,  Emanuela Gancia ,  Simon Gaines ,  Alberto Gobbi ,  Christopher Hurley ,  Tammy Ladduwahetty ,  Olivier Rene ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC: C07D279/02 ,  C07D417/12 ,  C07D417/10

CPC classification number: C07D279/02 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, R1, R2, R3, R4, R5 R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.