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公开(公告)号：US08838394B2
公开(公告)日：2014-09-16
申请号：US13756760
申请日：2013-02-01
Applicant: California Institute of Technology
Inventor： Emil Kartalov , Aditya Rajagopal , Axel Scherer
CPC classification number: G06F19/20 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G01N21/6486 , G06F17/10 , G06F17/11 , G06F19/12 , G06F19/24 , Y02A50/53 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
Abstract translation: 本公开提供了用于多个检测样品中多个分析物的方法，系统，组合物和试剂盒。 在一些实例中，本公开提供方法，系统，组合物和试剂盒，其中可以通过获取信号的至少一个可定量分量的累积测量或测量，在单个样品体积中检测多个分析物。 在某些情况下，信号的附加组件或附加信号（或其组件）也被量化。 信号的每个信号或分量可以用于构建编码方案，然后可以使用它来确定是否存在任何分析物。
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公开(公告)号：US11950887B2
公开(公告)日：2024-04-09
申请号：US17020740
申请日：2020-09-14
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Dominic Yurk , Yaser Abu-Mostafa , Alaina Ann Brinley Rajagopal
CPC classification number: A61B5/02133 , A61B5/6832 , A61B5/7405 , A61B5/02141
Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.
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公开(公告)号：US20230240646A1
公开(公告)日：2023-08-03
申请号：US18128998
申请日：2023-03-30
Applicant: California Institute of Technology
Inventor： Alaina Ann Brinley Rajagopal , Aditya Rajagopal
CPC classification number: A61B8/0891 , A61B8/14 , A61B8/40 , A61B8/4236 , A61B8/4472 , G01S15/895
Abstract: An ultrasound measurement device includes: a processing device and multiple ultrasound sensors that capture tomographic information of a physiological structure. The ultrasound sensors include a first ultrasound sensor including a first transducer having a first frequency response with a first resonant frequency, and a second ultrasound sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits an ultrasound signal that is reflected by the physiological structure to create a reflected ultrasound signal, the first transducer generates a first received signal from the reflected ultrasound signal, the second transducer generates a second received signal from the reflected ultrasound signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.
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公开(公告)号：US20230151440A1
公开(公告)日：2023-05-18
申请号：US17810696
申请日：2022-07-05
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
IPC: C12Q1/70 , C12Q1/68 , C12Q1/6851
CPC classification number: C12Q1/701 , C12Q1/703 , C12Q1/68 , C12Q1/6851 , Y10T436/143333
Abstract: A non-transitory computer-readable storage medium storing executable instructions to cause a system to detect a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a measured change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.
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公开(公告)号：US11414716B2
公开(公告)日：2022-08-16
申请号：US16827590
申请日：2020-03-23
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
IPC: C12P19/34 , C12Q1/70 , C12Q1/68 , C12Q1/6851
Abstract: Medical systems for detecting a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a change in signal generated by the fluorophore and quencher, and measured by a sensor of the medical system, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, and measured by the sensor of the medical system, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.
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Patent Agency Ranking
公开(公告)号：US20200060644A1
公开(公告)日：2020-02-27
申请号：US16547544
申请日：2019-08-21
Applicant: California Institute of Technology
Inventor： Alaina Ann Brinley Rajagopal , Aditya Rajagopal
Abstract: Some implementations of the disclosure are directed to an ultrasound measurement device including: multiple ultrasound sensors to capture tomographical information of a physiological structure, each ultrasound sensor comprising a transducer having a respective resonant frequency, where each transducer has a frequency response that partially overlaps with a frequency response of another transducer; and a processing device to control and process measurements made by the ultrasound sensors. The device may be incorporated in an adhesive substrate configured to be adhered to a patient's skin in alignment with an artery of the patient. The processing device may use the multiple ultrasound sensors to compute the mean arterial pressure through the artery by performing operations of: measuring a circumference of the artery using the multiple ultrasound sensors; measuring a blood flow velocity using the same ultrasound sensors; and computing the mean arterial pressure using the measured arterial circumference and blood flow velocity.
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公开(公告)号：US10376892B2
公开(公告)日：2019-08-13
申请号：US15360691
申请日：2016-11-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya Rajagopal , Samson Chen , Axel Scherer , Christopher I. Walker
Abstract: PC board fluidic devices for performing a Polymerase Chain Reaction (PCR) are disclosed. The devices comprise a printed circuit board and a PCR chamber. The PCR chamber is a fluidic chamber and is located in, or is part of, the PC board. The PC board can include a coil trace heating element with a temperature sensor and controller.
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公开(公告)号：US10068051B2
公开(公告)日：2018-09-04
申请号：US14451876
申请日：2014-08-05
Applicant: California Institute of Technology
Inventor： Emil Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G01N33/48 , G01N33/50 , G06F19/20 , G06F19/12 , C12Q1/68 , G01N21/64 , C12Q1/6825 , C12Q1/6851 , G06F19/24 , G06F17/10 , G06F17/11
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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19.发明授权公开(公告)号：US09533308B2
公开(公告)日：2017-01-03
申请号：US13763352
申请日：2013-02-08
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya Rajagopal , Samson Chen , Axel Scherer , Christopher I. Walker
CPC classification number: B01L7/52 , B01L3/502707 , B01L2200/147 , B01L2300/0816 , B01L2300/0893 , B01L2300/12 , B01L2300/123 , B01L2300/1827 , B01L2300/1844 , C12Q1/686 , H05K1/0212 , H05K1/0272 , H05K1/028 , H05K3/46 , H05K3/4697 , Y10T29/49124
Abstract: An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB) fluidic device. The PCR chamber is a fluidic chamber and is located in, or is part of, the printed circuit board (PCB) fluidic device. A method for manufacturing an apparatus for performing the Polymerase Chain Reaction and a method for performing the Polymerase Chain Reaction are further disclosed.
Abstract translation: 公开了一种用于进行聚合酶链式反应（PCR）的装置。 该装置包括用于进行聚合酶链式反应的PCR室和印刷电路板（PCB）流体装置。 PCR室是流体室，并且位于印刷电路板（PCB）流体装置中或者是其中的一部分。 进一步公开了进行聚合酶链式反应的装置的制造方法和进行聚合酶链式反应的方法。
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公开(公告)号：US08841712B2
公开(公告)日：2014-09-23
申请号：US13852480
申请日：2013-03-28
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Axel Scherer , Michael D. Henry , Sameer Walavalkar , Thomas A. Tombrello , Andrew P. Homyk
IPC: H01L29/76 , G01N27/327 , H01L29/66 , H01L29/78
CPC classification number: C12Q1/02 , A61B5/04001 , G01N27/3275 , G01N27/4146 , G01R1/06711 , G01R1/07342 , H01L29/413 , H01L29/42376 , H01L29/4966 , H01L29/66477 , H01L29/78 , H01L29/7831
Abstract: A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar transistor allows for advantageous insertion into cellular membranes, and the biomimitec character of the gate element operates as an advantageous interface for sensing small amplitude voltages such as transmembrane cell potentials. The nano-pillar transistor can be used in various embodiments to stimulate cells, to measure cell response, or to perform a combination of both actions.
Abstract translation: 场效应纳米柱晶体管具有结合有生物医学部分的柱形门元件，其提供了优于现有技术器件的各种优点。 纳米柱晶体管的小尺寸允许有利地插入到细胞膜中，并且栅极元件的生物学特性作为用于感测小幅度电压（例如跨膜电池电位）的有利接口。 纳米柱晶体管可用于各种实施例中以刺激细胞，测量细胞反应或执行两种动作的组合。
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