公开(公告)号：US4885077A

公开(公告)日：1989-12-05

申请号：US272372

申请日：1988-11-17

Applicant: Mutlu Karakelle ,  Richard J. Zdrahala

Inventor： Mutlu Karakelle ,  Richard J. Zdrahala

IPC: G01N27/40

CPC classification number: G01N27/40

Abstract: A porous composite membrane comprises a base membrane of high mechanical strength and a coating of a hydrophilic polymer on the surface of the membrane and on the walls of the pores. The invention includes a method to prepare the membrane and a biosensor including the membrane.

Abstract translation: 多孔复合膜包括机械强度高的基膜和在膜表面和孔壁上的亲水性聚合物涂层。 本发明包括制备膜的方法和包括膜的生物传感器。

公开(公告)号：US4806430A

公开(公告)日：1989-02-21

申请号：US120901

申请日：1987-11-16

Applicant: David E. Spielvogel ,  Richard J. Zdrahala

Inventor： David E. Spielvogel ,  Richard J. Zdrahala

IPC: A61L29/08 ,  C09D183/04 ,  B32B9/06

CPC classification number: A61L29/085 ,  C09D183/04 ,  Y10T428/31663

Abstract: A film-forming siloxane composition having excellent adherent and lubricating properties comprising a reactive component having a combination of three siloxane polymers chemically crosslinked, and a non-reactive component dispersed therein. Substrates are dipped or otherwise coated with the compositions, at which time they are cured quickly under heat to a durable, adherent lubricating surface which is dry to the touch. Of particular advantage is the use of these films on hypodermic needles, razor blades, catheters and the like.

Abstract translation: 具有优异的粘附性和润滑性的成膜硅氧烷组合物包括具有三种经过化学交联的硅氧烷聚合物和分散在其中的非反应性组分的组合的反应性组分。 底物被浸渍或以其他方式涂覆组合物，此时它们在加热下快速固化成耐干燥的粘合润滑表面，该表面是干燥的。 特别的优点是在皮下注射针，剃刀刀片，导管等上使用这些膜。

公开(公告)号：US4647643A

公开(公告)日：1987-03-03

申请号：US796387

申请日：1985-11-08

Applicant: Richard J. Zdrahala ,  David Spielvogel

Inventor： Richard J. Zdrahala ,  David Spielvogel

IPC: C08G18/38 ,  C08G18/61

CPC classification number: C08G18/3893 ,  C08G18/61 ,  Y10S528/906

Abstract: Soft, non-blocking, thermoplastic polyurethanes are prepared by reacting a long chain polyester or polyether diol, a short chain diol, a diisocyanate and a silicone diol of the formula: ##STR1## wherein x has a value of about 1 to 30, y has a value of about 1 to 200, R is an alkylene group having 2 to 4 carbon atoms, R.sup.1 is selected from the group consisting of an alkyl group having 1 to 18 carbon atoms, a haloalkyl group having 1 to 18 carbon atoms, a phenyl group, a substituted phenyl group, or a phenylalkyl group, and V and W are divalent linking groups. A unique feature of the invention is that the polymers exhibit, less blocking, are less susceptible to hydrolysis and are highly transparent. These polyurethanes are particularly useful in fabricating medical tubing.

Abstract translation: 柔软的，非阻塞的热塑性聚氨酯通过使长链聚酯或聚醚二醇，短链二醇，二异氰酸酯和下式的硅氧烷二醇反应来制备：其中x具有约1至30的值，y 具有约1至200的值，R是具有2至4个碳原子的亚烷基，R 1选自具有1至18个碳原子的烷基，具有1至18个碳原子的卤代烷基， 苯基，取代苯基或苯基烷基，V和W是二价连接基团。 本发明的独特特征在于聚合物显示较少的阻塞性较不易水解并且是高度透明的。 这些聚氨酯在制造医用管道中特别有用。

公开(公告)号：US06443988B1

公开(公告)日：2002-09-03

申请号：US09193973

申请日：1998-11-18

Applicant: Jeffrey C. Felt ,  Mark A. Rydell ,  Richard J. Zdrahala ,  Alexander Arsenyev

Inventor： Jeffrey C. Felt ,  Mark A. Rydell ,  Richard J. Zdrahala ,  Alexander Arsenyev

IPC: A61F244

Abstract: A method, and related composition and apparatus for repairing a tissue site. The method involves the use of a curable polyurethane biomaterial composition having a plurality of parts adapted to be mixed at the time of use in order to provide a flowable composition and to initiate cure. The flowable composition can be delivered using minimally invasive means to a tissue site and there fully cured provide a permanent and biocompatible prosthesis for repair of the tissue site. Further provided are a mold apparatus, e.g., in the form of a balloon or tubular cavity, for receiving a biomaterial composition, and a method for delivering and filling the mold apparatus with a curable composition in situ to provide a prosthesis for tissue repair.

公开(公告)号：US06299448B1

公开(公告)日：2001-10-09

申请号：US09505567

申请日：2000-02-17

Applicant: Ivanka J. Zdrahala ,  Richard J. Zdrahala

Inventor： Ivanka J. Zdrahala ,  Richard J. Zdrahala

IPC: A61C800

CPC classification number: A61C8/0036 ,  A61C8/0006 ,  A61C2201/007

Abstract: The present invention relates generally to surgical implants intended for the augmentation, repair, and restoration of soft tissue (e.g. gingiva or cartilage), hard tissue (e.g. bone), and the like. More particularly, the present invention relates to the in vivo anchoring of cast implants by stent-like anchors made of a shape memory alloy and/or polymers which are desirably covered with a textile sleeve of a specific porosity.

Abstract translation: 本发明一般涉及用于增加，修复和恢复软组织（例如牙龈或软骨），硬组织（例如骨）等的外科植入物。 更具体地说，本发明涉及通过由形状记忆合金和/或聚合物制成的支架状锚固体的体内锚定，所述形状记忆合金和/或聚合物期望地被特定孔隙率的纺织套筒覆盖。

公开(公告)号：US5716660A

公开(公告)日：1998-02-10

申请号：US455714

申请日：1995-05-31

Applicant: Kevin Weadock ,  David J. Lentz ,  Richard J. Zdrahala

Inventor： Kevin Weadock ,  David J. Lentz ,  Richard J. Zdrahala

IPC: A61L27/00 ,  A61F2/06 ,  A61L17/00 ,  A61L27/34 ,  A61L27/48 ,  B05D3/00

CPC classification number: A61L27/34 ,  A61L27/48

Abstract: An implantable prosthesis comprising an expanded polytetraethylene member having pores present in its wall structure wherein said pores contain a solid insoluble biocompatible, biodegradable material of natural origin. A process of preparing said prostheses is also disclosed.

Abstract translation: 一种可植入假体，其包含在其壁结构中存在的孔的膨胀聚四亚乙基构件，其中所述孔含有天然来源的固体不溶性生物相容性可生物降解的材料。 还公开了制备所述假体的方法。

公开(公告)号：US5505887A

公开(公告)日：1996-04-09

申请号：US209543

申请日：1994-03-10

Applicant: Richard J. Zdrahala ,  Nicholas Popadiuk ,  Gerald Kalin ,  David J. Lentz

Inventor： Richard J. Zdrahala ,  Nicholas Popadiuk ,  Gerald Kalin ,  David J. Lentz

IPC: A61L29/04 ,  B29C47/00 ,  B29C47/24 ,  B29C47/86 ,  B29K27/18 ,  B29K105/04 ,  B29L23/00

CPC classification number: B29C47/86 ,  A61L29/041 ,  B29C47/0004 ,  B29C47/0023 ,  B29C47/24 ,  B29C47/862 ,  B29C47/864 ,  B29C47/866 ,  B29C47/0016 ,  B29K2027/18 ,  B29L2031/753

Abstract: An improved extrusion method is employed in a process which is used to form tubing for medical applications. The method includes providing an extrusion apparatus having a die which includes a die cavity and a mandrel within the die cavity. The die is rotated in a first rotational direction while the mandrel is rotated in a second rotational direction opposite the first direction. While the die and the mandrel are rotating, a PTFE paste is passed through the annular passage defined between the die and the mandrel. The die cavity is cooled to maintain the PTFE paste passing therethrough at a substantially non-elevated temperature.

Abstract translation: 在用于形成用于医疗应用的管道的方法中采用改进的挤出方法。 该方法包括提供具有模具的挤出设备，该模具在模腔内包括模腔和心轴。 模具沿着第一旋转方向旋转，同时心轴沿与第一方向相反的第二旋转方向旋转。 当模具和心轴旋转时，PTFE浆料通过限定在模具和心轴之间的环形通道。 冷却模腔以保持PTFE浆料在基本上不升高的温度下通过。

公开(公告)号：US4720521A

公开(公告)日：1988-01-19

申请号：US804209

申请日：1985-12-03

Applicant: David E. Spielvogel ,  Richard J. Zdrahala

Inventor： David E. Spielvogel ,  Richard J. Zdrahala

IPC: C08J5/18 ,  A61L29/08 ,  A61M5/32 ,  B32B15/08 ,  B32B27/00 ,  C08L83/07 ,  C09D183/04 ,  C09D183/07 ,  C08L83/04

CPC classification number: A61L29/085 ,  C09D183/04

Abstract: A film-forming siloxane composition having excellent adherent and lubricating properties comprising a reactive component having a combination of three siloxane polymers chemically crosslinked, and a non-reactive component dispersed therein. Substrates are dipped or otherwise coated with the compositions, at which time they are cured quickly under heat to a durable, adherent lubricating surface which is dry to the touch. Of particular advantage is the use of these films on hypodermic needles, razor blades, catheters and the like.

Abstract translation: 具有优异的粘附性和润滑性的成膜硅氧烷组合物包括具有三种经过化学交联的硅氧烷聚合物和分散在其中的非反应性组分的组合的反应性组分。 底物被浸渍或以其他方式涂覆组合物，此时它们在加热下快速固化成耐干燥的粘合润滑表面，该表面是干燥的。 特别的优点是在皮下注射针，剃刀刀片，导管等上使用这些膜。

公开(公告)号：US4190711A

公开(公告)日：1980-02-26

申请号：US838017

申请日：1977-09-29

Applicant: Richard J. Zdrahala ,  Frank E. Critchfield

Inventor： Richard J. Zdrahala ,  Frank E. Critchfield

IPC: C08G18/00 ,  C08G18/10 ,  C08G18/48 ,  C07C125/04 ,  C08G18/14

CPC classification number: C08G18/4837 ,  C08G18/10 ,  C08G2101/0008 ,  C08G2101/0066 ,  C08G2120/00 ,  Y10S521/914

Abstract: Thermoplastic polyether polyurethane elastomers are provided by reacting and forming: (a) a novel liquid polyurethane quasi-prepolymer having a free NCO content of from about 16 percent to about 25 percent; (b) a reactive poly(oxypropylene-oxyethylene) diol; and (c) as an extender, a short chain diol in the presence of (d) a catalyst. The elastomers can be either solid or microcellular, and they are suitable for production using Reaction Injection Molding (RIM) or conventional casting technology. The elastomers are useful in the production of automotive body panels, gears, seals and the like, and, since the elastomers are thermoplastic, any excess elastomer ("scrap") can be reused.

Abstract translation: 热塑性聚醚聚氨酯弹性体通过反应和形成：（a）具有约16％至约25％的游离NCO含量的新型液体聚氨酯预预聚物提供; （b）反应性聚（氧丙烯 - 氧乙烯）二醇; 和（c）作为增量剂，在（d）催化剂存在下的短链二醇。 弹性体可以是固体或微孔的，它们适用于使用反应注射成型（RIM）或常规铸造技术的生产。 弹性体可用于制造汽车车身板，齿轮，密封件等，并且由于弹性体是热塑性的，因此可以重复使用任何过量的弹性体（“废料”）。

公开(公告)号：US6080198A

公开(公告)日：2000-06-27

申请号：US964414

申请日：1997-11-04

Applicant: David J. Lentz ,  Nick Popadiuk ,  Peter Schmitt ,  Edward J. Dormier ,  Richard J. Zdrahala

Inventor： David J. Lentz ,  Nick Popadiuk ,  Peter Schmitt ,  Edward J. Dormier ,  Richard J. Zdrahala

IPC: A61L27/00 ,  A61F2/06 ,  A61L27/16 ,  A61L27/50

CPC classification number: A61F2/07 ,  A61F2/06 ,  A61F2/88 ,  A61L27/16 ,  A61L27/507 ,  A61F2002/072 ,  Y10S623/901

Abstract: An implantable microporous ePTFE tubular vascular graft exhibits long-term patency, superior radial tensile strength, reduction in tear propagation, and increases in suture retention strength and crush resistance. The graft includes an ePTFE tubular structure having a preselected microporous structure. The tubular structure is wrapped externally with a PTFE yarn in a helical fashion. The helical wrap of yarn is bonded to the exterior surface of the tubular structure by application of heat or heat in combination with force to form a composite structure which substantially maintains the porosity of the underlying tubular structure while increasing the suture retention strength, radial tensile strength, crush resistance, and tear propagation resistance.

Abstract translation: 可植入的微孔ePTFE管状血管移植物显示出长期通畅，优异的径向拉伸强度，撕裂增加的减少，以及缝线保持强度和抗压性的提高。 移植物包括具有预选微孔结构的ePTFE管状结构。 管状结构以螺旋方式用PTFE纱线外部包裹。 通过结合施加热量或热量将纱线的螺旋卷绕结合到管状结构的外表面，以形成复合结构，其基本上保持下面的管状结构的孔隙率，同时增加缝合线保持强度，径向拉伸强度 抗碎裂性和抗撕裂性。