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    Fluorinated polyetherurethanes and medical devices therefrom
    3.
    发明授权
    Fluorinated polyetherurethanes and medical devices therefrom 失效
    氟化聚醚聚氨酯和医疗器械

    公开(公告)号：US4935480A

    公开(公告)日：1990-06-19

    申请号：US325731

    申请日：1989-03-20

    申请人： Richard J. Zdrahala ,  Marc A. Strand

    发明人： Richard J. Zdrahala ,  Marc A. Strand

    IPC分类号： A61L33/06 ,  C08G18/10 ,  C08G18/50

    CPC分类号： C08G18/5015 ,  A61L33/068 ,  C08G18/10 ,  Y10S623/924

    摘要： Non-blocking, hemocompatible, thermoplastic, fluorinated polyetherurethanes and a method for their preparation from fluorinated polyether glycols, isocyanates, chain extenders and a non-fluorinated polyol. The method includes two steps in which the fluorinated glycol is reacted initially with the diisocyanate to give a prepolymer having terminal isocyanate groups, and the prepolymer is then reacted with the extender and non-fluorinated polyol. Medical devices are fabricated from the fluorinated polyetherurethane.

    摘要翻译： 非阻塞性，血液相容性，热塑性，氟化聚醚氨基甲酸酯及其由氟化聚醚二醇，异氰酸酯，扩链剂和非氟化多元醇制备的方法。 该方法包括两个步骤，其中氟化二醇首先与二异氰酸酯反应得到具有末端异氰酸酯基团的预聚物，然后预聚物与增量剂和非氟化多元醇反应。 医疗器械由氟化聚醚聚氨酯制成。

    Composite membrane, method for its preparation and electrolyte sensor including same
    4.
    发明授权
    Composite membrane, method for its preparation and electrolyte sensor including same 失效
    复合膜，其制备方法和包括其的电解质传感器

    公开(公告)号：US4885077A

    公开(公告)日：1989-12-05

    申请号：US272372

    申请日：1988-11-17

    申请人： Mutlu Karakelle ,  Richard J. Zdrahala

    发明人： Mutlu Karakelle ,  Richard J. Zdrahala

    IPC分类号： G01N27/40

    CPC分类号： G01N27/40

    摘要： A porous composite membrane comprises a base membrane of high mechanical strength and a coating of a hydrophilic polymer on the surface of the membrane and on the walls of the pores. The invention includes a method to prepare the membrane and a biosensor including the membrane.

    摘要翻译： 多孔复合膜包括机械强度高的基膜和在膜表面和孔壁上的亲水性聚合物涂层。 本发明包括制备膜的方法和包括膜的生物传感器。

    Film-forming silicone compositions having lubricating properties
    5.
    发明授权
    Film-forming silicone compositions having lubricating properties 失效
    具有润滑性能的成膜硅酮组合物

    公开(公告)号：US4806430A

    公开(公告)日：1989-02-21

    申请号：US120901

    申请日：1987-11-16

    申请人： David E. Spielvogel ,  Richard J. Zdrahala

    发明人： David E. Spielvogel ,  Richard J. Zdrahala

    IPC分类号： A61L29/08 ,  C09D183/04 ,  B32B9/06

    CPC分类号： A61L29/085 ,  C09D183/04 ,  Y10T428/31663

    摘要： A film-forming siloxane composition having excellent adherent and lubricating properties comprising a reactive component having a combination of three siloxane polymers chemically crosslinked, and a non-reactive component dispersed therein. Substrates are dipped or otherwise coated with the compositions, at which time they are cured quickly under heat to a durable, adherent lubricating surface which is dry to the touch. Of particular advantage is the use of these films on hypodermic needles, razor blades, catheters and the like.

    摘要翻译： 具有优异的粘附性和润滑性的成膜硅氧烷组合物包括具有三种经过化学交联的硅氧烷聚合物和分散在其中的非反应性组分的组合的反应性组分。 底物被浸渍或以其他方式涂覆组合物，此时它们在加热下快速固化成耐干燥的粘合润滑表面，该表面是干燥的。 特别的优点是在皮下注射针，剃刀刀片，导管等上使用这些膜。

    Soft non-blocking polyurethanes
    6.
    发明授权
    Soft non-blocking polyurethanes 失效
    软非阻燃聚氨酯

    公开(公告)号：US4647643A

    公开(公告)日：1987-03-03

    申请号：US796387

    申请日：1985-11-08

    申请人： Richard J. Zdrahala ,  David Spielvogel

    发明人： Richard J. Zdrahala ,  David Spielvogel

    IPC分类号： C08G18/38 ,  C08G18/61

    CPC分类号： C08G18/3893 ,  C08G18/61 ,  Y10S528/906

    摘要： Soft, non-blocking, thermoplastic polyurethanes are prepared by reacting a long chain polyester or polyether diol, a short chain diol, a diisocyanate and a silicone diol of the formula: ##STR1## wherein x has a value of about 1 to 30, y has a value of about 1 to 200, R is an alkylene group having 2 to 4 carbon atoms, R.sup.1 is selected from the group consisting of an alkyl group having 1 to 18 carbon atoms, a haloalkyl group having 1 to 18 carbon atoms, a phenyl group, a substituted phenyl group, or a phenylalkyl group, and V and W are divalent linking groups. A unique feature of the invention is that the polymers exhibit, less blocking, are less susceptible to hydrolysis and are highly transparent. These polyurethanes are particularly useful in fabricating medical tubing.

    摘要翻译： 柔软的，非阻塞的热塑性聚氨酯通过使长链聚酯或聚醚二醇，短链二醇，二异氰酸酯和下式的硅氧烷二醇反应来制备：其中x具有约1至30的值，y 具有约1至200的值，R是具有2至4个碳原子的亚烷基，R 1选自具有1至18个碳原子的烷基，具有1至18个碳原子的卤代烷基， 苯基，取代苯基或苯基烷基，V和W是二价连接基团。 本发明的独特特征在于聚合物显示较少的阻塞性较不易水解并且是高度透明的。 这些聚氨酯在制造医用管道中特别有用。

    Polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
    7.
    发明授权
    Polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents 有权
    聚合物涂层用聚合氧化物链接枝，包含共价键合的生物活性剂

    公开(公告)号：US06338904B1

    公开(公告)日：2002-01-15

    申请号：US09589784

    申请日：2000-06-08

    申请人： Birendra K. Patnaik ,  Richard J. Zdrahala

    发明人： Birendra K. Patnaik ,  Richard J. Zdrahala

    IPC分类号： B32B2740

    CPC分类号： A61L33/0029 ,  A61K47/59 ,  A61K47/60 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/10 ,  A61L33/0011 ,  Y10S623/90 ,  Y10T428/31551 ,  A61L27/18 ,  C08L75/04 ,  A61L29/06 ,  A61L31/06 ,  C08L71/02

    摘要： Disclosed are bio-active coating compositions for polymeric substrates. In particular, a bio-active coating is described which is the reaction product formed by providing a polymer backbone with at least one free isocyanate group, wherein the isocyanate group is pendant from the polymer backbone. There is further provided a hydrophilic, amine-terminated spacer which has at least one amine group at its first and second ends. One of the amine groups of the spacer is reacted with one or more of the isocyanate groups on the polymer backbone in the presence of an optional catalyst agent. A bio-active agent is then covalently bonded onto an unreacted end of the spacer in the presence of a catalyst. Also disclosed are coating compositions for a substrate and methods of preparing same.

    摘要翻译： 公开了用于聚合物基材的生物活性涂料组合物。 特别地，描述了生物活性涂层，其是通过向聚合物主链提供至少一个游离异氰酸酯基团形成的反应产物，其中异氰酸酯基团从聚合物主链悬挂。 还提供亲水的胺封端的间隔物，其在其第一和第二端具有至少一个胺基。 在任选的催化剂存在下，间隔基的一个胺基与聚合物主链上的一个或多个异氰酸酯基团反应。 然后在催化剂的存在下将生物活性剂共价键合到间隔物的未反应端上。 还公开了用于底物的涂料组合物及其制备方法。

    Method for forming a yarn wrapped PTFE tubular prosthesis
    9.
    发明授权
    Method for forming a yarn wrapped PTFE tubular prosthesis 失效
    用于形成缠绕PTFE管状假体的纱线的方法

    公开(公告)号：US6080198A

    公开(公告)日：2000-06-27

    申请号：US964414

    申请日：1997-11-04

    申请人： David J. Lentz ,  Nick Popadiuk ,  Peter Schmitt ,  Edward J. Dormier ,  Richard J. Zdrahala

    发明人： David J. Lentz ,  Nick Popadiuk ,  Peter Schmitt ,  Edward J. Dormier ,  Richard J. Zdrahala

    IPC分类号： A61L27/00 ,  A61F2/06 ,  A61L27/16 ,  A61L27/50

    CPC分类号： A61F2/07 ,  A61F2/06 ,  A61F2/88 ,  A61L27/16 ,  A61L27/507 ,  A61F2002/072 ,  Y10S623/901

    摘要： An implantable microporous ePTFE tubular vascular graft exhibits long-term patency, superior radial tensile strength, reduction in tear propagation, and increases in suture retention strength and crush resistance. The graft includes an ePTFE tubular structure having a preselected microporous structure. The tubular structure is wrapped externally with a PTFE yarn in a helical fashion. The helical wrap of yarn is bonded to the exterior surface of the tubular structure by application of heat or heat in combination with force to form a composite structure which substantially maintains the porosity of the underlying tubular structure while increasing the suture retention strength, radial tensile strength, crush resistance, and tear propagation resistance.

    摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅，优异的径向拉伸强度，撕裂增加的减少，以及缝线保持强度和抗压性的提高。 移植物包括具有预选微孔结构的ePTFE管状结构。 管状结构以螺旋方式用PTFE纱线外部包裹。 通过结合施加热量或热量将纱线的螺旋卷绕结合到管状结构的外表面，以形成复合结构，其基本上保持下面的管状结构的孔隙率，同时增加缝合线保持强度，径向拉伸强度 抗碎裂性和抗撕裂性。