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    Polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
    2.
    发明授权
    Polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents 有权
    聚合物涂层用聚合氧化物链接枝，包含共价键合的生物活性剂

    公开(公告)号：US06338904B1

    公开(公告)日：2002-01-15

    申请号：US09589784

    申请日：2000-06-08

    申请人： Birendra K. Patnaik ,  Richard J. Zdrahala

    发明人： Birendra K. Patnaik ,  Richard J. Zdrahala

    IPC分类号： B32B2740

    CPC分类号： A61L33/0029 ,  A61K47/59 ,  A61K47/60 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/10 ,  A61L33/0011 ,  Y10S623/90 ,  Y10T428/31551 ,  A61L27/18 ,  C08L75/04 ,  A61L29/06 ,  A61L31/06 ,  C08L71/02

    摘要： Disclosed are bio-active coating compositions for polymeric substrates. In particular, a bio-active coating is described which is the reaction product formed by providing a polymer backbone with at least one free isocyanate group, wherein the isocyanate group is pendant from the polymer backbone. There is further provided a hydrophilic, amine-terminated spacer which has at least one amine group at its first and second ends. One of the amine groups of the spacer is reacted with one or more of the isocyanate groups on the polymer backbone in the presence of an optional catalyst agent. A bio-active agent is then covalently bonded onto an unreacted end of the spacer in the presence of a catalyst. Also disclosed are coating compositions for a substrate and methods of preparing same.

    摘要翻译： 公开了用于聚合物基材的生物活性涂料组合物。 特别地，描述了生物活性涂层，其是通过向聚合物主链提供至少一个游离异氰酸酯基团形成的反应产物，其中异氰酸酯基团从聚合物主链悬挂。 还提供亲水的胺封端的间隔物，其在其第一和第二端具有至少一个胺基。 在任选的催化剂存在下，间隔基的一个胺基与聚合物主链上的一个或多个异氰酸酯基团反应。 然后在催化剂的存在下将生物活性剂共价键合到间隔物的未反应端上。 还公开了用于底物的涂料组合物及其制备方法。

    Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
    6.
    发明授权
    Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents 失效
    制备聚合物涂层的方法，接枝聚环氧乙烷链含有共价键合的生物活性剂

    公开(公告)号：US5877263A

    公开(公告)日：1999-03-02

    申请号：US755189

    申请日：1996-11-25

    申请人： Birendra K. Patnaik ,  Richard J. Zdrahala

    发明人： Birendra K. Patnaik ,  Richard J. Zdrahala

    IPC分类号： A61K47/48 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  A61L33/00 ,  C08G18/30

    CPC分类号： A61L33/0029 ,  A61K47/48192 ,  A61K47/48215 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/10 ,  A61L33/0011 ,  Y10S623/90 ,  Y10T428/31551

    摘要： Disclosed are bio-active coating compositions for polymeric substrates. In particular, a bio-active coating is described which is the reaction product formed by providing a polymer backbone with at least one free isocyanate group, wherein the isocyanate group is pendant from the polymer backbone. There is further provided a hydrophilic, amine-terminated spacer which has at least one amine group at its first and second ends. One of the amine groups of the spacer is reacted with one or more of the isocyanate groups on the polymer backbone in the presence of an optional catalyst agent. A bio-active agent is then covalently bonded onto an unreacted end of the spacer in the presence of a catalyst. Also disclosed are coating compositions for a substrate and methods of preparing same.

    摘要翻译： 公开了用于聚合物基材的生物活性涂料组合物。 特别地，描述了生物活性涂层，其是通过向聚合物主链提供至少一个游离异氰酸酯基团形成的反应产物，其中异氰酸酯基团从聚合物主链悬挂。 还提供亲水的胺封端的间隔物，其在其第一和第二端具有至少一个胺基。 在任选的催化剂存在下，间隔基的一个胺基与聚合物主链上的一个或多个异氰酸酯基团反应。 然后在催化剂的存在下将生物活性剂共价键合到间隔物的未反应端上。 还公开了用于底物的涂料组合物及其制备方法。

    Fluorinated polyetherurethanes and medical devices therefrom
    10.
    发明授权
    Fluorinated polyetherurethanes and medical devices therefrom 失效
    氟化聚醚聚氨酯和医疗器械

    公开(公告)号：US4935480A

    公开(公告)日：1990-06-19

    申请号：US325731

    申请日：1989-03-20

    申请人： Richard J. Zdrahala ,  Marc A. Strand

    发明人： Richard J. Zdrahala ,  Marc A. Strand

    IPC分类号： A61L33/06 ,  C08G18/10 ,  C08G18/50

    CPC分类号： C08G18/5015 ,  A61L33/068 ,  C08G18/10 ,  Y10S623/924

    摘要： Non-blocking, hemocompatible, thermoplastic, fluorinated polyetherurethanes and a method for their preparation from fluorinated polyether glycols, isocyanates, chain extenders and a non-fluorinated polyol. The method includes two steps in which the fluorinated glycol is reacted initially with the diisocyanate to give a prepolymer having terminal isocyanate groups, and the prepolymer is then reacted with the extender and non-fluorinated polyol. Medical devices are fabricated from the fluorinated polyetherurethane.

    摘要翻译： 非阻塞性，血液相容性，热塑性，氟化聚醚氨基甲酸酯及其由氟化聚醚二醇，异氰酸酯，扩链剂和非氟化多元醇制备的方法。 该方法包括两个步骤，其中氟化二醇首先与二异氰酸酯反应得到具有末端异氰酸酯基团的预聚物，然后预聚物与增量剂和非氟化多元醇反应。 医疗器械由氟化聚醚聚氨酯制成。