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公开(公告)号：US5874032A
公开(公告)日：1999-02-23
申请号：US545799
申请日：1996-04-15
CPC分类号： B29C47/86 , A61L29/041 , B29C47/0004 , B29C47/0023 , B29C47/24 , B29C47/862 , B29C47/864 , B29C47/866 , B29C47/0016 , B29K2027/18 , B29L2031/753
摘要： An improved method is provided for extruding ePTFE tube (12) for use in medical applications. A tube (12) of PTFE is extruded, preferably in an extrusion process, using counter-rotated die components (22, 26). The die component (16) is maintained at a constant temperature during processing. The resulting green tube (12) has enhanced fibrous state formation in a direction perpendicular to the direction of extrusion. The PTFE green tube (12) is then subjected to secondary operations such as stretching and expansion to yield medical product. The ePTFE tube (12) structure is defined by nodes interconnected by elongate fibrils. Both the nodes and fibrils are substantially randomly tilted with respect to the longitudinal axis of the tube (12). This particular structure yields a tube (12) which exhibits a high degree of radial tear strength useful in medical applications.
摘要翻译： PCT No.PCT / US95 / 03018 Sec。 371日期：1996年4月15日 102（e）日期1996年4月15日PCT 1995年3月9日PCT公布。 公开号WO95 / 24304 日期1995年9月14日提供用于挤出用于医疗应用的ePTFE管（12）的改进方法。 PTFE的管（12）优选地在挤出过程中使用反向旋转的模具部件（22,26）挤出。 在加工期间，模具部件（16）保持恒定的温度。 所得到的绿色管（12）在垂直于挤出方向的方向上具有增强的纤维形成。 然后将PTFE绿色管（12）进行二次操作，例如拉伸和膨胀以产生医疗产品。 ePTFE管（12）结构由通过细长原纤维互连的节点限定。 节点和原纤维相对于管（12）的纵向轴线基本上随机倾斜。 这种特殊的结构产生一个管（12），其在医疗应用中表现出高度的径向撕裂强度。
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公开(公告)号：US6080198A
公开(公告)日：2000-06-27
申请号：US964414
申请日：1997-11-04
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61L27/16 , A61L27/507 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long-term patency, superior radial tensile strength, reduction in tear propagation, and increases in suture retention strength and crush resistance. The graft includes an ePTFE tubular structure having a preselected microporous structure. The tubular structure is wrapped externally with a PTFE yarn in a helical fashion. The helical wrap of yarn is bonded to the exterior surface of the tubular structure by application of heat or heat in combination with force to form a composite structure which substantially maintains the porosity of the underlying tubular structure while increasing the suture retention strength, radial tensile strength, crush resistance, and tear propagation resistance.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅，优异的径向拉伸强度，撕裂增加的减少，以及缝线保持强度和抗压性的提高。 移植物包括具有预选微孔结构的ePTFE管状结构。 管状结构以螺旋方式用PTFE纱线外部包裹。 通过结合施加热量或热量将纱线的螺旋卷绕结合到管状结构的外表面，以形成复合结构，其基本上保持下面的管状结构的孔隙率，同时增加缝合线保持强度，径向拉伸强度 抗碎裂性和抗撕裂性。
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公开(公告)号：US6001125A
公开(公告)日：1999-12-14
申请号：US40880
申请日：1998-03-18
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/507 , A61F2002/0086 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube. The stent provides patency to the endoprosthesis.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅性，优异的径向拉伸强度和缝合孔伸长抗性。 移植物包括第一ePTFE管和周向设置在第一管上的第二ePTFE管。 第一个ePTFE管表现出足以促进细胞内皮细胞向内生长和愈合的孔隙度。 第二ePTFE管表现出超过第一管的径向拉伸强度的增强的径向强度。 支架对内假体提供通畅。
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公开(公告)号：US5607478A
公开(公告)日：1997-03-04
申请号：US616047
申请日：1996-03-14
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61L27/16 , A61L27/507 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long-term patency, superior radial tensile strength, reduction in tear propagation, and increases in suture retention strength and crush resistance. The graft includes an ePTFE tubular structure having a preselected microporous structure. The tubular structure is wrapped externally with a PTFE yarn in a helical fashion. The helical wrap of yarn is bonded to the exterior surface of the tubular structure by application of heat or heat in combination with force to form a composite structure which substantially maintains the porosity of the underlying tubular structure while increasing the suture retention strength, radial tensile strength, crush resistance, and tear propagation resistance.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅，优异的径向拉伸强度，撕裂增加的减少，以及缝线保持强度和抗压性的提高。 移植物包括具有预选微孔结构的ePTFE管状结构。 管状结构以螺旋方式用PTFE纱线外部包裹。 通过结合施加热量或热量将纱线的螺旋卷绕结合到管状结构的外表面，以形成复合结构，其基本上保持下面的管状结构的孔隙率，同时增加缝合线保持强度，径向拉伸强度 抗碎裂性和抗撕裂性。
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公开(公告)号：US06530765B1
公开(公告)日：2003-03-11
申请号：US09595548
申请日：2000-06-16
IPC分类号： B29C4724
CPC分类号： B29C47/86 , A61L29/041 , B29C47/0004 , B29C47/0023 , B29C47/24 , B29C47/862 , B29C47/866 , B29K2027/18 , B29L2031/753 , C08L27/18
摘要： An improved method and apparatus is provided for extruding ePTFE tube for use in medical applications. A tube of PTFE is extruded, preferably in an extrusion process, using counter-rotated die components. The die component is maintained at a constant temperature during processing. The resulting green tube has enhanced fibrous state formation in a direction perpendicular to the direction of extrusion. The PTFE green tube is then subjected to secondary operations such as stretching and expansion to yield medical product. The ePTFE tube structure is defined by nodes interconnected by elongate fibrils. Both the nodes and fibrils are substantially randomly tilted with respect to the longitudinal axis of the tube. This particular structure yields a tube which exhibits a high degree of radial tear strength useful in medical applications.
摘要翻译： 提供了用于挤出用于医疗应用的ePTFE管的改进的方法和装置。 使用反向旋转的模具部件挤压PTFE管，优选在挤出工艺中。 在加工过程中，模具部件保持恒定的温度。 所得到的绿色管在垂直于挤出方向的方向上增强了纤维形态。 然后对PTFE绿色管进行拉伸和膨胀等二次操作以产生医疗产品。 ePTFE管结构由通过细长纤维互连的节点限定。 节点和原纤维相对于管的纵向轴线基本上随机倾斜。 这种特殊结构产生了一种在医疗应用中显示高度径向撕裂强度的管。
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公开(公告)号：US6036724A
公开(公告)日：2000-03-14
申请号：US8265
申请日：1998-01-16
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/507 , A61F2002/0086 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅性，优异的径向拉伸强度和缝合孔伸长抗性。 移植物包括第一ePTFE管和周向设置在第一管上的第二ePTFE管。 第一个ePTFE管表现出足以促进细胞内皮细胞向内生长和愈合的孔隙度。 第二ePTFE管表现出超过第一管的径向拉伸强度的增强的径向强度。
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公开(公告)号：US5800512A
公开(公告)日：1998-09-01
申请号：US588052
申请日：1996-01-22
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/507 , A61F2002/0086 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅性，优异的径向拉伸强度和缝合孔伸长抗性。 移植物包括第一ePTFE管和周向设置在第一管上的第二ePTFE管。 第一个ePTFE管表现出足以促进细胞内皮细胞向内生长和愈合的孔隙度。 第二ePTFE管表现出超过第一管的径向拉伸强度的增强的径向强度。
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