公开(公告)号：US20080103530A1

公开(公告)日：2008-05-01

申请号：US11554825

申请日：2006-10-31

申请人： Holly S. Vitense ,  Li Wang ,  Denise Dirnberger ,  Melissa M. Rhodes ,  Douglas A. Hettrick ,  Shantanu Sarkar

发明人： Holly S. Vitense ,  Li Wang ,  Denise Dirnberger ,  Melissa M. Rhodes ,  Douglas A. Hettrick ,  Shantanu Sarkar

IPC分类号： A61N1/00

CPC分类号： A61N1/37258 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/053 ,  A61N1/37247 ,  G16H40/63

摘要： The capability to suspend a patient alert relating to a monitored physiologic parameters addresses a need to selectively shut off a patient-alert signal or signals during the time a patient is being treated for an excursion in the parameter. Of course, in general a signal call attention to a patient's a potentially deleterious status or condition for which they should seek medical attention. Once a chronically-implanted monitoring device has detected or provided information about the parameter relative to a desired value, trend, or range and a clinician has been notified and intervened the alert signal is temporarily disabled for a predetermined period. That is, once the notification occurs and alert has served its purpose, the alert mechanism is selectively deactivated while the patient ostensibly begins to gradually correct the monitored physiologic parameter under a caregiver's direction and control. After which time, the alert will reactivate.

摘要翻译： 暂停与所监测的生理参数相关的患者警报的能力解决了在患者被治疗参数期间偏移的时间期间选择性地切断病人警报信号或信号的需要。 当然，一般来说，一个信号会引起对患者的一个潜在的有害的状态或状况的关注，他们应该寻求医疗护理。 一旦长期植入的监测装置已经相对于期望值，趋势或范围已经检测或提供了关于参数的信息，并且已通知临床医生并且中介了警报信号暂时禁用预定时间段。 也就是说，一旦通知发生并且警报已经达到其目的，则警告机制被选择性地去激活，同时患者表面上开始逐渐校正受照顾者的方向和控制下的监测的生理参数。 之后，警报将重新启动。

公开(公告)号：US20080078350A1

公开(公告)日：2008-04-03

申请号：US11541622

申请日：2006-09-28

申请人： Li Wang

发明人： Li Wang

IPC分类号： F02N1/00 ,  H02K7/18

CPC分类号： F02N3/02 ,  F02N3/04 ,  Y10T74/13

摘要： A power generator includes a supporting frame, a generator supported by the supporting frame, and an engine mechanism including an engine driving the generator and a recoil starter for starting the engine via starter cable. The power generator further includes a hand-free starter arrangement which includes a foot pedal movably supported by the supporting frame and a transmission unit coupling a pulling end of the starter cable with the foot pedal to transmit the downward stepping force of the foot pedal to a pulling force of the starter cable. A downward displacement of the foot pedal is corresponding to an operation length of the starter cable to start the engine such that when the foot pedal is depressed, the starter cable is pulled with the operation length to start the engine in a hand-free manner.

摘要翻译： 发电机包括支撑框架，由支撑框架支撑的发电机，以及包括驱动发电机的发动机和用于通过起动电缆起动发动机的反冲起动器的发动机机构。 发电机还包括一个免提起动装置，它包括由支撑框架可移动地支撑的脚踏板和一个将起动器电缆的牵引端与脚踏板相耦合的传动装置，以将脚踏板的向下踏力传递到 起动电缆的拉力。 脚踏板的向下位移对应于启动发动机的启动器电缆的操作长度，使得当踏板被压下时，起动器电缆以操作长度被拉动以起动发动机。

公开(公告)号：US20070202164A1

公开(公告)日：2007-08-30

申请号：US11674557

申请日：2007-02-13

申请人： Yuqing Wang ,  Li Wang ,  Xun Zhang

发明人： Yuqing Wang ,  Li Wang ,  Xun Zhang

IPC分类号： A61K36/185 ,  A61K9/20

CPC分类号： A61K9/2077 ,  A61K9/1611 ,  A61K9/1635 ,  A61K9/1652 ,  A61K36/19

摘要： A pharmaceutical formulation containing 50-90% by weight a powdered extract of Andrographis paniculata and 5-50% by weight a powdered blocking agent. The formulation may further contain a pore-forming agent, a filler, a lubricant, or a glidant. Also described are a method for preparing this pharmaceutical formulation and a method for treating inflammatory disease, immunological disease, or respiratory disease with it.

摘要翻译： 一种药物制剂，其含有50-90重量％的穿心莲的粉末提取物和5-50重量％的粉末封闭剂。 制剂还可以含有成孔剂，填料，润滑剂或助流剂。 还描述了制备该药物制剂的方法和用它治疗炎性疾病，免疫疾病或呼吸系统疾病的方法。

公开(公告)号：US20070156194A1

公开(公告)日：2007-07-05

申请号：US11323314

申请日：2005-12-30

申请人： Li Wang

发明人： Li Wang

IPC分类号： A61N1/362

CPC分类号： A61N1/3756 ,  A61B5/0452 ,  A61B5/0472 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/3682 ,  A61N1/3684

摘要： Embodiments of close loop optimization of atrio-ventricular (A-V) delay interval and/or inter-ventricular (V-V) timing are disclosed. An implantable medical device includes a housing that supports a processing means adapted for implantation in a patient. There can be two or more electrodes electrically coupled to the processing means where the two or more electrodes can be used for sensing a patient's cardiac signals, which include a far-field EGM. The processing means can determine a width of a P-wave from the sensed far-field EGM. Also included can be a means for delivering an adapted cardiac pacing therapy based upon the width of the P-wave, including revised A-V delay and/or V-V temporal intervals.

摘要翻译： 公开了房室（A-V）延迟间隔和/或心室间（V-V）定时的闭环优化的实施例。 可植入医疗装置包括支撑适于植入患者体内的处理装置的外壳。 可以有两个或更多个电极耦合到处理装置的电极，其中两个或更多个电极可用于感测患者的心脏信号，其包括远场EGM。 处理装置可以从感测的远场EGM确定P波的宽度。 还包括可以用于基于P波的宽度（包括修正的A-V延迟和/或V-V时间间隔）递送适应的心脏起搏治疗的手段。

公开(公告)号：US20060257464A9

公开(公告)日：2006-11-16

申请号：US10957977

申请日：2004-10-04

申请人： Robert MacDonald ,  Li Wang

发明人： Robert MacDonald ,  Li Wang

IPC分类号： A61K9/127 ,  C12N15/88

CPC分类号： C12N15/88

摘要： The present invention provides optimized transfection reagents comprising mixtures of cationiclipoids. In particular, the present invention provides DNA delivery vehicles based on identifying the optimal hydrophobicity of novel cationic phospholipid derivatives that, alone or in combination, form complexes with DNA (lipoplexes) and exhibit enhanced transfection activity.

摘要翻译： 本发明提供包含阳离子脂质混合物的优化的转染试剂。 特别地，本发明提供了基于鉴定与DNA单独或组合形成复合物（lipoplexes）并显示增强的转染活性的新型阳离子磷脂衍生物的最佳疏水性的DNA递送载体。

公开(公告)号：US07005744B2

公开(公告)日：2006-02-28

申请号：US10605308

申请日：2003-09-22

申请人： Xiangdong Chen ,  Li Wang

发明人： Xiangdong Chen ,  Li Wang

IPC分类号： H01L29/41 ,  H01L29/49

CPC分类号： H01L27/10888 ,  H01L21/76897 ,  H01L23/485 ,  H01L27/10861 ,  H01L27/10873 ,  H01L2924/0002 ,  H01L2924/00

摘要： A structure and method are provided for a conductor line stack of an integrated circuit. The conductor line stack includes a layer of a first material such as heavily doped polysilicon or a metal silicide. A layer of a second material such as a metal is formed over the layer of first material, the layer of second material having an upper portion and a lower portion. A pair of first spacers is disposed on sidewalls of the upper portion, wherein the lower portion has width defined by a combined width of the upper portion and the pair of first spacers. A pair of second spacers is formed on sidewalls of the first spacers, the lower portion and the layer of first material. The conductor line stack structure is well adapted for formation of a borderless bitline contact in contact therewith.

摘要翻译： 为集成电路的导线堆叠提供了一种结构和方法。 导线堆叠包括第一材料层，例如重掺杂多晶硅或金属硅化物。 在第一材料层上形成诸如金属的第二材料层，第二材料层具有上部和下部。 一对第一间隔件设置在上部的侧壁上，其中下部具有由上部和第一对间隔件的组合宽度限定的宽度。 在第一间隔件，下部和第一材料层的侧壁上形成一对第二间隔件。 导体线堆叠结构很好地适于形成与其接触的无边界位线接触。

公开(公告)号：US20060002952A1

公开(公告)日：2006-01-05

申请号：US11217562

申请日：2005-09-01

申请人： Deborah Haines ,  Gordon Allan ,  John Ellis ,  Brian Meehan ,  Edward Clark ,  Lori Hassard ,  John Harding ,  Catherine Charreyre ,  Gilles Chappuis ,  Francis McNeilly ,  Li Wang ,  Lorne Babiuk ,  Andrew Potter ,  Philip Willson

发明人： Deborah Haines ,  Gordon Allan ,  John Ellis ,  Brian Meehan ,  Edward Clark ,  Lori Hassard ,  John Harding ,  Catherine Charreyre ,  Gilles Chappuis ,  Francis McNeilly ,  Li Wang ,  Lorne Babiuk ,  Andrew Potter ,  Philip Willson

IPC分类号： C12Q1/70 ,  C07H21/04 ,  A61K39/12 ,  A61K48/00 ,  C07K14/005 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/51 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/10043 ,  C12Q1/701

摘要： The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.

公开(公告)号：US20050137636A1

公开(公告)日：2005-06-23

申请号：US10818098

申请日：2004-04-05

申请人： Bruce Gunderson ,  Amisha Patel ,  Chad Bounds ,  Li Wang

发明人： Bruce Gunderson ,  Amisha Patel ,  Chad Bounds ,  Li Wang

IPC分类号： A61N1/08 ,  A61N1/37

CPC分类号： A61N1/3706 ,  A61N2001/083

摘要： A method and apparatus for detecting a lead-related condition that includes determining whether a first oversensing criteria is satisfied, determining whether a second oversensing criteria is satisfied, determining whether an impedance criteria has been satisfied, and generating an alert in response to more than one of the first oversensing criteria, the second over sensing criteria and the impedance criteria being satisfied.

摘要翻译： 一种用于检测引线相关状况的方法和装置，包括确定是否满足第一过度标准，确定是否满足第二过度标准，确定是否已经满足阻抗标准，以及响应于多于一个产生警报 的第一超检标准，第二过度感测标准和阻抗标准得到满足。

公开(公告)号：US20050080460A1

公开(公告)日：2005-04-14

申请号：US10684759

申请日：2003-10-14

申请人： Li Wang ,  Yong Cho ,  Kevin Kuehn ,  Glenn Zillmer ,  Nirav Sheth

发明人： Li Wang ,  Yong Cho ,  Kevin Kuehn ,  Glenn Zillmer ,  Nirav Sheth

IPC分类号： A61B5/053 ,  A61N1/362 ,  A61N1/365 ,  A61N1/39

CPC分类号： A61B5/4869 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/7203 ,  A61B5/7285 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3962

摘要： A fluid status monitoring system for use in implantable cardiac stimulation or monitoring devices is provided for monitoring changes in thoracic fluid content. A fluid status monitor includes excitation pulse generating and control circuitry, and voltage and current measurement and control circuitry for performing a series of cardiac-gated, intra-thoracic impedance measurements. The cardiac-gated measurements are filtered or time-averaged to provide a fluid status impedance value, with respiratory noise removed. Based on comparative analysis of the fluid status impedance value, a clinically relevant trend in fluid status may be tentatively diagnosed and a fluid status response provided. Cross-check intra-thoracic impedance measurements performed using the same or a different excitation pathway and a different measurement pathway than the primary intra-thoracic impedance measurement configuration may be used to verify a tentative diagnosis.

摘要翻译： 提供用于植入式心脏刺激或监测装置的流体状态监测系统，用于监测胸腔液含量的变化。 流体状态监测器包括激励脉冲发生和控制电路以及用于执行一系列心脏门控胸腔内阻抗测量的电压和电流测量和控制电路。 心脏门控测量被过滤或时间平均以提供流体状态阻抗值，消除呼吸噪声。 基于流体状态阻抗值的比较分析，可以暂时诊断流体状态的临床相关趋势，并提供流体状态响应。 使用与主要的胸内阻抗测量配置相同或不同的激发途径和不同的测量路径进行的交叉检查胸内阻抗测量可用于验证临时诊断。

公开(公告)号：US06792183B1

公开(公告)日：2004-09-14

申请号：US09990487

申请日：2001-11-16

申请人： Yuqiao Liu ,  Li Wang ,  Zhupei Shi ,  Wei-Shin Tsay

发明人： Yuqiao Liu ,  Li Wang ,  Zhupei Shi ,  Wei-Shin Tsay

IPC分类号： G02B626

CPC分类号： G02B6/3636 ,  G02B6/3656 ,  G02B6/423 ,  G02B6/4231 ,  G02B6/4239

摘要： Techniques for bonding aligned optical parts to a substrate are disclosed. According to one embodiment, one or more wedges are used to fill in gaps between aligned optical parts and a substrate. Using an appropriate material, the wedges are respectively slid in till respective contacts between the aligned optical parts and the wedges are established, a small amount of a bonding agent is then only applied to the respect contacts. As a result, the shrinkage that may be caused by the bonding agent to destabilize the aligned optical parts is minimized and the alignments among the optical parts are preserved and can sustain under very high environmental stresses.

摘要翻译： 公开了将对准的光学部件粘合到基底的技术。 根据一个实施例，一个或多个楔用于填充对准的光学部件和基板之间的间隙。 使用适当的材料，将楔子分别滑入直到对准的光学部件之间的相应触点，并且楔形物被建立，然后仅将少量的粘合剂施加到相关的触点。 结果，可以使结合剂引起的使对准的光学部件不稳定的收缩被最小化，并且光学部件之间的对准被保持并且可以在非常高的环境应力下维持。