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公开(公告)号：US20060257464A9
公开(公告)日：2006-11-16
申请号：US10957977
申请日：2004-10-04
申请人： Robert MacDonald , Li Wang
发明人： Robert MacDonald , Li Wang
CPC分类号： C12N15/88
摘要： The present invention provides optimized transfection reagents comprising mixtures of cationiclipoids. In particular, the present invention provides DNA delivery vehicles based on identifying the optimal hydrophobicity of novel cationic phospholipid derivatives that, alone or in combination, form complexes with DNA (lipoplexes) and exhibit enhanced transfection activity.
摘要翻译： 本发明提供包含阳离子脂质混合物的优化的转染试剂。 特别地，本发明提供了基于鉴定与DNA单独或组合形成复合物（lipoplexes）并显示增强的转染活性的新型阳离子磷脂衍生物的最佳疏水性的DNA递送载体。
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2.发明申请Compositions and methods for enhanced delivery of compounds via transfection complexes 审中-公开通过转染复合物增强化合物的组合物和方法公开(公告)号：US20050261221A1
公开(公告)日：2005-11-24
申请号：US11069115
申请日：2005-03-01
申请人： Li Wang , Robert MacDonald
发明人： Li Wang , Robert MacDonald
摘要： The present invention relates to compositions and methods for enhanced delivery of compounds (e.g., drugs, nucleic acids, peptides, etc.) via transfection complexes (e.g., liposomes). In particular, the present invention utilizes agents that synergistically enhance the ability of a transfection complex to deliver a compound to cells or tissue.
摘要翻译： 本发明涉及通过转染复合物（例如，脂质体）增强化合物（例如药物，核酸，肽等）的递送的组合物和方法。 特别地，本发明利用协同增强转染复合物将化合物递送至细胞或组织的能力的试剂。
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公开(公告)号：US20050142179A1
公开(公告)日：2005-06-30
申请号：US10957977
申请日：2004-10-01
申请人： Robert MacDonald , Li Wang
发明人： Robert MacDonald , Li Wang
IPC分类号： A61K9/127 , C12N20060101 , C12N15/85 , C12N15/88
CPC分类号： C12N15/88
摘要： The present invention provides optimized transfection reagents comprising mixtures of cationiclipoids. In particular, the present invention provides DNA delivery vehicles based on identifying the optimal hydrophobicity of novel cationic phospholipid derivatives that, alone or in combination, form complexes with DNA (lipoplexes) and exhibit enhanced transfection activity.
摘要翻译： 本发明提供包含阳离子脂质混合物的优化的转染试剂。 特别地，本发明提供了基于鉴定与DNA单独或组合形成复合物（lipoplexes）并显示增强的转染活性的新型阳离子磷脂衍生物的最佳疏水性的DNA递送载体。
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公开(公告)号：US20160186555A1
公开(公告)日：2016-06-30
申请号：US14810715
申请日：2015-07-28
IPC分类号： E21B47/18
摘要： An apparatus, method, and system for generating pressure pulses in a drilling fluid flowing within coiled tubing assembly is described that includes; a flow throttling device longitudinally and axially positioned within the center of a main valve actuator assembly that allows main exit flow fluid to flow past a drive shaft and motor such that the pilot fluid and the main exit flow fluid causes one or more flow throttling devices to generate large, rapid controllable pulses. The pulses generated by the flow throttling device thereby allow transmission of well-developed signals easily distinguished from any noise resulting from other vibrations due to nearby equipment within the borehole or exterior to the borehole, or within the coiled tubing assembly wherein the signals also provide predetermined height, width and shape of the signals.
摘要翻译： 描述了一种用于在连续油管组件内流动的钻井液中产生压力脉冲的装置，方法和系统，其包括： 纵向和轴向地定位在主阀致动器组件的中心内的流量节流装置，其允许主出口流动流体流过驱动轴和马达，使得先导流体和主出口流动流体使一个或多个流量节流装置 产生大的，快速的可控脉冲。 由流量节流装置产生的脉冲由此允许良好发展的信号的传输容易地与由钻孔内或钻井外部附近的设备或在连续油管组件内的其他振动引起的任何噪声区分开，其中信号还提供预定的 信号的高度，宽度和形状。
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5.发明申请Controlled Full Flow Pressure Pulser for Measurement While Drilling (MWD) Device 有权控制全流量压力发生器，用于钻孔测量（MWD）装置公开(公告)号：US20130048379A1
公开(公告)日：2013-02-28
申请号：US13368997
申请日：2012-08-21
IPC分类号： E21B21/08
CPC分类号： E21B47/187
摘要： An apparatus, method, and system described for generating pressure pulses in drilling fluid utilizing a flow throttling device which includes a controllable pulser operating sequentially within a downhole assembly within a drill string of a drill pipe. The system includes drilling fluid, fluid flow, and fluid drilling pump which when combined creates fluid flow into a bore pipe annulus within the downhole assembly creating a base line bore pipe pressure wherein bore pipe pressure is sensed via a sensor and information is sent to a Digital Signal Processor (DSP) that interprets the information. The DSP also receives information from an annulus pressure sensor that senses drilling fluid pressure as it returns to the pump. The DSP recognizes pressure variation input from the annulus pressure sensor and bore pipe pressure sensor and detects pressure variation providing signals as data information to the DSP, determining required action to adjust pulser operation.
摘要翻译： 所描述的用于在钻井液中产生压力脉冲的装置，方法和系统，其利用流量节流装置，该流量节流装置包括在钻杆的钻柱内的井下组件内依次操作的可控脉动器。 该系统包括钻井流体，流体流动和流体钻井泵，其在组合时产生流入井下组件内的孔管环中的流体流动，产生基线孔管道压力，其中通过传感器感测钻孔管压力，并将信息发送到 解码信息的数字信号处理器（DSP）。 DSP还从环形压力传感器接收信息，该环形压力传感器在返回到泵时感测到钻井液压力。 DSP识别来自环形压力传感器和钻孔管压力传感器的压力变化输入，并将压力变化提供信号作为数据信息检测到DSP，确定调节脉冲发生器运行的所需动作。
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公开(公告)号：US20050252147A1
公开(公告)日：2005-11-17
申请号：US11117640
申请日：2005-04-28
申请人： Robert MacDonald , William Dawson
发明人： Robert MacDonald , William Dawson
CPC分类号： E04C1/395 , E04B2002/0206 , E04B2002/0217 , E04B2002/0267
摘要： A system of columnar blocks and stacking blocks interlock with each other in the construction of a pilaster or column and a fence panel, respectively, for use in a fence. The columnar blocks are generally square and the stacking blocks are generally rectangular. The columnar block faces may contain one or more slots to give a column an appearance of a masonry joint. Blocks have at least one interlocking element that permits a positive connection between courses of the blocks when the interlocking element is received in an overlying block.
摘要翻译： 柱状块和堆叠块的系统分别在用于围栏的pilaster或柱和栅栏板的结构中彼此联锁。 柱状块通常是正方形的，并且堆叠块通常是矩形的。 柱状块面可以包含一个或多个槽，以使柱具有砖石接头的外观。 块具有至少一个互锁元件，当互锁元件被接收在上覆块中时，允许块的坡道之间的正连接。
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公开(公告)号：US20050242468A1
公开(公告)日：2005-11-03
申请号：US11117639
申请日：2005-04-28
申请人： Robert MacDonald , William Dawson
发明人： Robert MacDonald , William Dawson
IPC分类号： B28B11/04 , B29C33/00 , B29C33/40 , B29C39/00 , B29C39/02 , B29C39/26 , B29C41/00 , B29C41/22 , B29C70/02 , B29C70/58 , B44F9/04 , E04H17/00
CPC分类号： B29C39/003 , B29C33/0011 , B29C33/405 , B29C39/025 , B29C39/26 , B29C41/003 , B29C41/22 , B29C67/243 , B29C70/025 , B29C70/026 , B29K2105/06 , B29K2503/08 , B29L2031/73 , B44F9/04 , E04H2017/006
摘要： A capping block having a waterproof shell that enables the quick and easy construction of a structurally sound column or pillar. The capping block comprises a composite material that has the appearance of natural stone.
摘要翻译： 封盖块具有防水外壳，能够快速简便地构造结构合理的立柱或支柱。 封盖块包括具有天然石材外观的复合材料。
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公开(公告)号：US09133664B2
公开(公告)日：2015-09-15
申请号：US13336981
申请日：2011-12-23
摘要： An apparatus, method, and system for generating pressure pulses in a drilling fluid flowing within coiled tubing assembly is described that includes; a flow throttling device longitudinally and axially positioned within the center of a main valve actuator assembly that allows main exit flow fluid to flow past a drive shaft and motor such that the pilot fluid and the main exit flow fluid causes one or more flow throttling devices to generate large, rapid controllable pulses. The pulses generated by the flow throttling device thereby allow transmission of well-developed signals easily distinguished from any noise resulting from other vibrations due to nearby equipment within the borehole or exterior to the borehole, or within the coiled tubing assembly wherein the signals also provide predetermined height, width and shape of the signals.
摘要翻译： 描述了一种用于在连续油管组件内流动的钻井液中产生压力脉冲的装置，方法和系统，其包括： 纵向和轴向地定位在主阀致动器组件的中心内的流量节流装置，其允许主出口流动流体流过驱动轴和马达，使得先导流体和主出口流动流体使一个或多个流量节流装置 产生大的，快速的可控脉冲。 由流量节流装置产生的脉冲由此允许良好发展的信号的传输容易地与由钻孔内或钻井外部附近的设备或在连续油管组件内的其他振动引起的任何噪声区分开，其中信号还提供预定的 信号的高度，宽度和形状。
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公开(公告)号：US09822635B2
公开(公告)日：2017-11-21
申请号：US14810715
申请日：2015-07-28
摘要： An apparatus, method, and system for generating pressure pulses in a drilling fluid flowing within coiled tubing assembly is described that includes; a flow throttling device longitudinally and axially positioned within the center of a main valve actuator assembly that allows main exit flow fluid to flow past a drive shaft and motor such that the pilot fluid and the main exit flow fluid causes one or more flow throttling devices to generate large, rapid controllable pulses. The pulses generated by the flow throttling device thereby allow transmission of well-developed signals easily distinguished from any noise resulting from other vibrations due to nearby equipment within the borehole or exterior to the borehole, or within the coiled tubing assembly wherein the signals also provide predetermined height, width and shape of the signals.
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10.发明授权Controlled full flow pressure pulser for measurement while drilling (MWD) device 有权控制全流量压力脉冲发生器，用于钻孔测量（MWD）装置公开(公告)号：US09309762B2
公开(公告)日：2016-04-12
申请号：US13368997
申请日：2012-08-21
CPC分类号： E21B47/187
摘要： An apparatus, method, and system described for generating pressure pulses in drilling fluid utilizing a flow throttling device which includes a controllable pulser operating sequentially within a downhole assembly within a drill string of a drill pipe. The system includes drilling fluid, fluid flow, and fluid drilling pump which when combined creates fluid flow into a bore pipe annulus within the downhole assembly creating a base line bore pipe pressure wherein bore pipe pressure is sensed via a sensor and information is sent to a Digital Signal Processor (DSP) that interprets the information. The DSP also receives information from an annulus pressure sensor that senses drilling fluid pressure as it returns to the pump. The DSP recognizes pressure variation input from the annulus pressure sensor and bore pipe pressure sensor and detects pressure variation providing signals as data information to the DSP, determining required action to adjust pulser operation.
摘要翻译： 所描述的用于在钻井液中产生压力脉冲的装置，方法和系统，其利用流量节流装置，该流量节流装置包括在钻杆的钻柱内的井下组件内依次操作的可控脉动器。 该系统包括钻井流体，流体流动和流体钻井泵，其在组合时产生流入井下组件内的孔管环中的流体流动，产生基线孔管道压力，其中通过传感器感测钻孔管压力，并将信息发送到 解码信息的数字信号处理器（DSP）。 DSP还从环形压力传感器接收信息，该环形压力传感器在返回到泵时感测到钻井液压力。 DSP识别来自环形压力传感器和钻孔管压力传感器的压力变化输入，并将压力变化提供信号作为数据信息检测到DSP，确定调节脉冲发生器运行的所需动作。
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