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公开(公告)号：US20050032045A1
公开(公告)日：2005-02-10
申请号：US10866013
申请日：2004-06-10
Applicant: Suresh Tikoo , Alexandre Zakhartchouk , Lorne Babiuk , Radhey Kaushik , Philip Griebel
Inventor： Suresh Tikoo , Alexandre Zakhartchouk , Lorne Babiuk , Radhey Kaushik , Philip Griebel
IPC: C07K14/075 , C12N15/861 , C12Q1/70
CPC classification number: C07K14/005 , C07K2319/33 , C12N2710/10322 , C12N2810/405 , C12N2810/859
Abstract: The present invention relates to chimeric adenovirus capsid proteins comprising a part of or all of an adenovirus capsid protein and a binding partner of a cell-surface binding site on a cell present in gut associated lymphoid tissues (GALT) of a mammal, wherein the chimeric adenovirus capsid protein is capable of binding the cell present in gut associated lymphoid tissues (GALT). In some examples, the adenovirus capsid protein is located on the surface of the adenovirus capsid. The present invention provides adenovirus capsids comprising a chimeric capsid protein. The present invention also provides complexes comprising a chimeric adenovirus capsid protein bound to a cell in GALT. The present invention also provides encapsidation systems and vectors, in particular adenovirus vectors, capable of expressing a chimeric adenovirus capsid protein encompassed within the invention. The present invention also provides viral particles, host cells and compositions comprising such vectors, in particular for use in vaccines, methods of eliciting an immune response and methods for targeted delivery of heterologous proteins, such as antigens, to target cells.
Abstract translation: 本发明涉及包含哺乳动物肠道相关淋巴组织（GALT）中存在的细胞上的一部分或全部腺病毒衣壳蛋白和细胞表面结合位点的结合配偶体的嵌合腺病毒衣壳蛋白，其中嵌合 腺病毒衣壳蛋白能够结合存在于肠道相关淋巴组织（GALT）中的细胞。 在一些实例中，腺病毒衣壳蛋白位于腺病毒衣壳的表面上。 本发明提供了包含嵌合衣壳蛋白的腺病毒衣壳。 本发明还提供了包含与GALT中的细胞结合的嵌合腺病毒衣壳蛋白的复合物。 本发明还提供能够表达包含在本发明内的嵌合腺病毒衣壳蛋白的包衣系统和载体，特别是腺病毒载体。 本发明还提供病毒颗粒，宿主细胞和包含这种载体的组合物，特别是用于疫苗，引发免疫应答的方法和用于将异源蛋白质例如抗原靶向递送至靶细胞的方法。
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公开(公告)号：US20080050402A1
公开(公告)日：2008-02-28
申请号：US11811642
申请日：2007-06-11
Applicant: Yan Zhou , Yeun-Kyung Shin , Lorne Babiuk , Qiang Liu
Inventor： Yan Zhou , Yeun-Kyung Shin , Lorne Babiuk , Qiang Liu
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/5254 , C12N7/00 , C12N2760/16122 , C12N2760/16161
Abstract: Attenuated influenza virus variants comprising substitutions in NS1 that interfere with viral replication and phosphatidylinositol 3-kinase activation are described. NS1 variant polypeptides, polynucleotides encoding NS1 variant polypeptides, a reverse genetics system for producing attenuated influenza virus NS1 variants, immunogenic compositions comprising live attenuated influenza virus NS1 variants, methods of stimulating an immune response against influenza virus, methods of interfering with influenza virus replication, and methods of treating and preventing influenza virus infection are described.
Abstract translation: 描述了包含干扰病毒复制和磷脂酰肌醇3-激酶活化的NS1中的取代的减毒流感病毒变体。 NS1变体多肽，编码NS1变体多肽的多核苷酸，用于产生减毒流感病毒NS1变体的反向遗传学系统，包含活减毒流感病毒NS1变体的免疫原性组合物，刺激针对流感病毒的免疫应答的方法，干扰流感病毒复制的方法， 并描述了治疗和预防流感病毒感染的方法。
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公开(公告)号：US20060292177A1
公开(公告)日：2006-12-28
申请号：US11485525
申请日：2006-07-12
Applicant: Deborah Haines , Gordon Allan , John Ellis , Brian Meehan , Edward Clark , Lori Hassard , John Harding , Catherine Charreyre , Gilles Chappuis , Francis McNeilly , Li Wang , Lorne Babiuk , Andrew Potter , Philip Willson
Inventor： Deborah Haines , Gordon Allan , John Ellis , Brian Meehan , Edward Clark , Lori Hassard , John Harding , Catherine Charreyre , Gilles Chappuis , Francis McNeilly , Li Wang , Lorne Babiuk , Andrew Potter , Philip Willson
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , A61K48/00 , A61K2039/51 , A61K2039/53 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2750/10022 , C12N2750/10034 , C12N2750/10043 , C12Q1/701
Abstract: The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.
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公开(公告)号：US20060008466A1
公开(公告)日：2006-01-12
申请号：US11127061
申请日：2005-05-10
Applicant: Shokrollah Elahi , Volker Gerdts , Lorne Babiuk
Inventor： Shokrollah Elahi , Volker Gerdts , Lorne Babiuk
CPC classification number: A61K38/1709 , C07K14/4723
Abstract: Methods for the treatment and prevention of microbial infection, such as infections caused by bacteria, viruses, fungi and parasites are disclosed, as are adjuvants for use with vaccines against such microbes. The methods use porcine β-defensins, such as porcine β-defensin-1 and are particularly useful for treating or preventing infections caused by gram-negative bacteria, such as pertussis.
Abstract translation: 公开了用于治疗和预防微生物感染的方法，例如由细菌，病毒，真菌和寄生虫引起的感染，以及用于针对这种微生物的疫苗的佐剂。 该方法使用猪β-防御素，例如猪β-防御素-1，并且特别可用于治疗或预防革兰氏阴性细菌如百日咳引起的感染。
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公开(公告)号：US5151267A
公开(公告)日：1992-09-29
申请号：US219939
申请日：1988-07-15
Applicant: Lorne Babiuk , Sylvia van den Hurk , Tim Zamb , David Fitzpatrick
Inventor： Lorne Babiuk , Sylvia van den Hurk , Tim Zamb , David Fitzpatrick
CPC classification number: C07K14/005 , G01N33/6854 , A61K39/00 , C12N2710/16722 , G01N2333/03
Abstract: Subunit vaccines against bovine herpesvirus type 1 are provided, as well as methods of vaccination and methods of making the subunit antigen employed in the vaccines.
Abstract translation: 提供了针对牛疱疹病毒1型的亚单位疫苗，以及疫苗的方法和制备疫苗中使用的亚单位抗原的方法。
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Patent Agency Ranking
公开(公告)号：US20090280125A1
公开(公告)日：2009-11-12
申请号：US12386906
申请日：2009-04-23
Applicant: Scott Napper , Peter Hedlin , Philip Griebel , Lorne Babiuk , Neil Cashman , Avijit Chakrabartty , Andrew Potter
Inventor： Scott Napper , Peter Hedlin , Philip Griebel , Lorne Babiuk , Neil Cashman , Avijit Chakrabartty , Andrew Potter
IPC: A61K39/395 , C07K7/00 , C07K14/00 , A61K39/00 , C12N15/11 , C12N15/00 , C12N1/21 , C12P21/02 , A61K31/7088 , C07K16/00 , G01N33/53
CPC classification number: C07K14/47 , A61K39/0007 , A61K2039/6037 , C07K7/06 , C07K7/08 , C07K16/2872 , C07K2317/34 , G01N33/6893 , G01N33/6896 , G01N2333/705 , G01N2800/2828
Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.
Abstract translation: 描述了包含朊病毒表位和其融合物的朊病毒肽，其显示增强的免疫原性。 还描述了治疗和诊断朊病毒疾病的方法。
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公开(公告)号：US20070128700A1
公开(公告)日：2007-06-07
申请号：US11654869
申请日：2007-01-17
Applicant: Qiang Liu , Suresh Tikoo , Philip Willson , Lorne Babiuk
Inventor： Qiang Liu , Suresh Tikoo , Philip Willson , Lorne Babiuk
CPC classification number: C07K14/005 , A61K2039/525 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2750/10021 , C12N2750/10043 , C12N2750/10052
Abstract: The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function.
Abstract translation: 本发明涉及培养圆环病毒，特别是猪圆环病毒的方法。 本发明提供了在表达哺乳动物腺病毒E1功能的哺乳动物细胞中培养猪圆环病毒的组合物和方法。
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公开(公告)号：US20070009550A1
公开(公告)日：2007-01-11
申请号：US11522237
申请日：2006-09-15
Applicant: Deborah Haines , Gordon Allan , John Ellis , Brian Meehan , Edward Clark , Lori Hassard , John Harding , Catherine Charreyre , Gilles Chappuis , Francis McNeilly , Li Wang , Lorne Babiuk , Andrew Potter , Philip Willson
Inventor： Deborah Haines , Gordon Allan , John Ellis , Brian Meehan , Edward Clark , Lori Hassard , John Harding , Catherine Charreyre , Gilles Chappuis , Francis McNeilly , Li Wang , Lorne Babiuk , Andrew Potter , Philip Willson
IPC: A61K39/395 , A61K39/12
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , A61K48/00 , A61K2039/51 , A61K2039/53 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2750/10022 , C12N2750/10034 , C12N2750/10043 , C12Q1/701
Abstract: The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.
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公开(公告)号：US20050238660A1
公开(公告)日：2005-10-27
申请号：US10492002
申请日：2002-10-07
Applicant: Lorne Babiuk , Rolf Hecker
Inventor： Lorne Babiuk , Rolf Hecker
IPC: A61K45/00 , A61K31/00 , A61K31/522 , A61K31/551 , A61K31/7072 , A61K31/7076 , A61K31/7088 , A61K39/00 , A61K39/12 , A61K39/245 , A61K39/39 , A61K45/06 , A61K48/00 , A61P31/00 , A61P31/12 , A61P35/00
CPC classification number: A61K31/00 , A61K39/12 , A61K39/245 , A61K39/39 , A61K45/06 , A61K2039/545 , A61K2039/55561 , A61K2039/55566 , C12N2710/16734 , A61K2300/00
Abstract: The invention involves methods and compositions of an immunostimulatory nucleic acid in combination with other therapeutic formulations such as oil-in-water emulsions. The combination of therapeutics are administered in various dosages or at various time schedules for the treatment of disorders such as disease and cancer.
Abstract translation: 本发明涉及免疫刺激性核酸与其它治疗剂例如水包油乳剂组合的方法和组合物。 治疗剂的组合以各种剂量或各种时间表施用以治疗诸如疾病和癌症的病症。
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公开(公告)号：US06946448B2
公开(公告)日：2005-09-20
申请号：US10155867
申请日：2002-05-23
Applicant: Volker Gerdts , Lorne Babiuk , Sylvia van Drunen Littel-van den Hurk , Philip J. Griebel
CPC classification number: A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/5252 , A61K2039/53 , A61K2039/54 , A61K2039/542 , A61K2039/55505 , A61K2039/57 , C12N2710/16734 , C12N2730/10134
Abstract: Methods of nucleic acid immunization comprising the in utero delivery of nucleic acid molecules that encode one or more selected antigens to a vertebrate fetus are disclosed.
Abstract translation: 公开了包含将脊椎动物胎儿编码一种或多种选择的抗原的核酸分子的子宫内递送的核酸免疫方法。
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