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    IMPLANTABLE SENSORS HAVING HIGH IMPEDANCE COUPLINGS PROVIDING CURRENT PATHWAYS FOR IMPROVED FAULT TOLERANCE
    2.
    发明申请
    IMPLANTABLE SENSORS HAVING HIGH IMPEDANCE COUPLINGS PROVIDING CURRENT PATHWAYS FOR IMPROVED FAULT TOLERANCE 审中-公开
    具有提供电流路径的高阻抗耦合的可插入传感器，用于改善故障容限

    公开(公告)号：US20070265666A1

    公开(公告)日：2007-11-15

    申请号：US11380529

    申请日：2006-04-27

    申请人： Jonathan Roberts ,  W. Wold ,  Glenn Zillmer

    发明人： Jonathan Roberts ,  W. Wold ,  Glenn Zillmer

    IPC分类号： A61N1/00

    CPC分类号： A61N1/056 ,  A61N1/0563 ,  A61N1/36564 ,  A61N1/37 ,  A61N1/3962 ,  A61N2001/083

    摘要： One aspect of the invention involves a possible fault scenario due to a breach of an inner layer of insulation of an elongated medical electrical lead which couples an active electrical circuit for an active implantable medical device (AIMD)—typically within a conductive AIMD housing—to a sensor disposed within a sensor capsule. In one form, the AIMD provides physiological sensing of a patient parameter, such as endocardial pressure via a chronically implanted absolute pressure sensor. In such a physiological monitor, a high impedance connection is established between the active electrical circuit and the conductive AIMD housing. In a therapy delivering AIMD, a high impedance connection is established between therapy electrodes and the active electrical circuit. As a result, any errant electrical current(s) will be shunted directly to the reference-ground of the sensor-bearing lead in lieu of traveling through a patient's tissue or conductive body fluid.

    摘要翻译： 本发明的一个方面涉及可能的故障情况，这是由于细长的医疗电线的绝缘层的内部破裂，其将用于有源可植入医疗装置（AIMD）的有源电路（典型地在导电AIMD外壳内）耦合到 设置在传感器胶囊内的传感器。 在一种形式中，AIMD通过长期植入的绝对压力传感器提供患者参数的生理感测，例如心内膜压。 在这样的生理监视器中，在有源电路和导电AIMD外壳之间建立高阻抗连接。 在提供AIMD的治疗中，在治疗电极和有源电路之间建立了高阻抗连接。 结果，任何错误的电流将被直接分流到传感器承载引线的参考地，以代替穿过病人的组织或导电体液。

    Method and apparatus for monitoring tissue fluid content for use in an implantable cardiac device
    3.
    发明申请
    Method and apparatus for monitoring tissue fluid content for use in an implantable cardiac device 有权
    用于监测可植入心脏装置中使用的组织液含量的方法和装置

    公开(公告)号：US20050080460A1

    公开(公告)日：2005-04-14

    申请号：US10684759

    申请日：2003-10-14

    申请人： Li Wang ,  Yong Cho ,  Kevin Kuehn ,  Glenn Zillmer ,  Nirav Sheth

    发明人： Li Wang ,  Yong Cho ,  Kevin Kuehn ,  Glenn Zillmer ,  Nirav Sheth

    IPC分类号： A61B5/053 ,  A61N1/362 ,  A61N1/365 ,  A61N1/39

    CPC分类号： A61B5/4869 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/7203 ,  A61B5/7285 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3962

    摘要： A fluid status monitoring system for use in implantable cardiac stimulation or monitoring devices is provided for monitoring changes in thoracic fluid content. A fluid status monitor includes excitation pulse generating and control circuitry, and voltage and current measurement and control circuitry for performing a series of cardiac-gated, intra-thoracic impedance measurements. The cardiac-gated measurements are filtered or time-averaged to provide a fluid status impedance value, with respiratory noise removed. Based on comparative analysis of the fluid status impedance value, a clinically relevant trend in fluid status may be tentatively diagnosed and a fluid status response provided. Cross-check intra-thoracic impedance measurements performed using the same or a different excitation pathway and a different measurement pathway than the primary intra-thoracic impedance measurement configuration may be used to verify a tentative diagnosis.

    摘要翻译： 提供用于植入式心脏刺激或监测装置的流体状态监测系统，用于监测胸腔液含量的变化。 流体状态监测器包括激励脉冲发生和控制电路以及用于执行一系列心脏门控胸腔内阻抗测量的电压和电流测量和控制电路。 心脏门控测量被过滤或时间平均以提供流体状态阻抗值，消除呼吸噪声。 基于流体状态阻抗值的比较分析，可以暂时诊断流体状态的临床相关趋势，并提供流体状态响应。 使用与主要的胸内阻抗测量配置相同或不同的激发途径和不同的测量路径进行的交叉检查胸内阻抗测量可用于验证临时诊断。

    Multi-site PESP with fusion pacing
    4.
    发明申请
    Multi-site PESP with fusion pacing 审中-公开
    多站点PESP与融合起搏

    公开(公告)号：US20060247698A1

    公开(公告)日：2006-11-02

    申请号：US11116877

    申请日：2005-04-28

    申请人： John Burnes ,  Glenn Zillmer ,  D. Deno

    发明人： John Burnes ,  Glenn Zillmer ,  D. Deno

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627

    摘要： In some embodiments, a method of operating an implantable cardiac pacing device to provide coupled ventricular pacing may include one or more of the following steps: (a) sensing ventricular events at a first ventricular site and generating a ventricular sense event signal in response thereto, (b) providing coupled pacing pulses simultaneously at the first ventricular site and at a second ventricular site at a ventricular extra stimulus interval (VESI) timed from immediately preceding ventricular sense event signals sufficient to effect post-extra-systolic potentiation (PESP) of the ventricular sites, and (c) providing pacing pulse at the second ventricular site after sensing ventricular events at the first ventricular site.

    摘要翻译： 在一些实施例中，操作可植入心脏起搏装置以提供联合心室起搏的方法可以包括以下步骤中的一个或多个：（a）感测第一心室位点处的心室事件并响应于此产生心室感测事件信号， （b）在心室额外刺激间隔（VESI）的第一心室部位和第二心室部位处同时提供耦合的起搏脉冲，其从紧接在前的心室感测事件信号定时，足以影响术后收缩期增强（PESP） 心室部位，以及（c）在感测第一心室部位的心室事件后在第二心室部位提供起搏脉冲。

    Multiple pacing output channels
    5.
    发明申请
    Multiple pacing output channels 有权
    多起搏输出通道

    公开(公告)号：US20050075677A1

    公开(公告)日：2005-04-07

    申请号：US10680695

    申请日：2003-10-07

    申请人： Vincent Ganion ,  Glenn Zillmer

    发明人： Vincent Ganion ,  Glenn Zillmer

    IPC分类号： A61N1/362 ,  A61N1/368

    CPC分类号： A61N1/3627 ,  A61N1/3684

    摘要： An implantable medical device includes two or more pacing output channels coupled to a single unipolar electrode or bipolar electrode pair. The implantable medical device can control each pacing output channel to deliver pacing pulses via the single electrode or electrode pair at different times and with different amplitudes. In some embodiments, the implantable medical device is used to deliver extra-systolic stimulation therapy. In such embodiments, a first pacing output channel can be controlled to deliver pacing pulses via the electrode or electrode pair with an amplitude sufficient to depolarize a chamber of the heart. A second pacing output channel is controlled to deliver extra-systolic pulses, which can have a lower amplitude than the pacing pulses, via the electrode or electrode pair an extra-systolic interval after sensed or paced depolarizations of the chamber. In some embodiments, the implantable medical device delivers ESS therapy and cardiac resynchronization therapy (CRT).

    摘要翻译： 可植入医疗装置包括耦合到单个单极电极或双极电极对的两个或多个起搏输出通道。 可植入医疗装置可以控制每个起搏输出通道在不同时间和不同振幅下通过单个电极或电极对输送起搏脉冲。 在一些实施例中，可植入医疗装置用于输送收缩期刺激疗法。 在这样的实施例中，可以控制第一起搏输出通道，以经由电极或电极对以足以使心脏腔室去极化的振幅来输送起搏脉冲。 第二起搏输出通道被控制以通过电极或电极对输出超声心动过速脉冲，其可以具有比起搏脉冲更低的振幅，在腔室的感测或起搏去极化之后的收缩期间隔。 在一些实施例中，可植入医疗装置递送ESS治疗和心脏再同步治疗（CRT）。

    Intravascular medical device
    7.
    发明申请
    Intravascular medical device 失效
    血管内医疗器械

    公开(公告)号：US20070179581A1

    公开(公告)日：2007-08-02

    申请号：US11342734

    申请日：2006-01-30

    申请人： Charles Dennis ,  George Klein ,  Ursula Gebhardt ,  Kenneth Anderson ,  Glenn Zillmer

    发明人： Charles Dennis ,  George Klein ,  Ursula Gebhardt ,  Kenneth Anderson ,  Glenn Zillmer

    IPC分类号： A61N1/36

    CPC分类号： A61N1/372 ,  A61N1/37205

    摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.

    摘要翻译： 可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。 系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。 以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。

    Cardiac pacing modality having improved blanking, timing, and therapy delivery methods for extra-systolic stimulation pacing therapy
    10.
    发明申请
    Cardiac pacing modality having improved blanking, timing, and therapy delivery methods for extra-systolic stimulation pacing therapy 有权
    心脏起搏模式具有改善的消隐，时机和治疗收费刺激起搏治疗方法

    公开(公告)号：US20050090872A1

    公开(公告)日：2005-04-28

    申请号：US10692990

    申请日：2003-10-24

    申请人： D. Deno ,  Vincent Splett ,  Jeffrey Gillberg ,  Glenn Zillmer ,  Ruth Klepfer ,  Karen Kleckner

    发明人： D. Deno ,  Vincent Splett ,  Jeffrey Gillberg ,  Glenn Zillmer ,  Ruth Klepfer ,  Karen Kleckner

    IPC分类号： A61N20060101 ,  A61N1/362 ,  A61N1/365

    CPC分类号： A61N1/365 ,  A61N1/3627

    摘要： The present invention relates to the secure delivery of an extra-systolic stimulation (ESS) therapy to treat cardiac dysfunction that employs atrial and/or ventricular extra-systoles via pacing-like stimulation of the heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (benefit) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). Further experience with ESS has led to improved implementation methods that depend on better blanking, ESS stimulation timing (of an “extra-systolic interval” or ESI), and ESS therapy delivery options and guidance. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.

    摘要翻译： 本发明涉及一种收缩期刺激（ESS）疗法的安全递送，以治疗心脏功能障碍，其通过心脏起搏样刺激使用心房和/或心室外的心脏。 这些额外的收缩期必须正确定时，以获得对心肌力学（益处）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。 ESS的进一步经验导致改进的实施方法取决于更好的消隐，ESS刺激时间（“收缩期间期”或ESI）和ESS治疗递送选项和指导。 这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。