公开(公告)号：US20170240933A1

公开(公告)日：2017-08-24

申请号：US15441343

申请日：2017-02-24

申请人： INVISTA North America S.á r.I.

发明人： Paul S. Pearlman ,  Alex Van Eck Conradie ,  Changlin Chen ,  Adriana Leonora Botes

IPC分类号： C12P7/44 ,  C12P7/18 ,  C12P7/42 ,  C12N9/04 ,  C12N15/52 ,  C12N9/10 ,  C12N9/00 ,  C12N9/02 ,  C12N9/16 ,  C12P13/00 ,  C12N9/80

CPC分类号： C12P7/44 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1096 ,  C12N9/13 ,  C12N9/16 ,  C12N9/80 ,  C12N9/93 ,  C12N15/52 ,  C12P7/18 ,  C12P7/42 ,  C12P13/001 ,  C12P13/005 ,  C12Y101/01258 ,  C12Y102/01063 ,  C12Y206/01 ,  C12Y208/03012 ,  C12Y301/02 ,  C12Y305/01062 ,  C12Y602/01005

摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.

公开(公告)号：US09617572B2

公开(公告)日：2017-04-11

申请号：US14138827

申请日：2013-12-23

申请人： INVISTA North America S.á r.l.

发明人： Adriana Leonora Botes ,  Alex Van Eck Conradie ,  Changlin Chen ,  Paul S. Pearlman

IPC分类号： C12P7/44 ,  C12P13/02 ,  C12P7/24 ,  C08G69/28 ,  C12P13/00 ,  C12P7/18 ,  C12P7/42 ,  C12N15/52

CPC分类号： C12P7/44 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1096 ,  C12N9/13 ,  C12N9/16 ,  C12N9/80 ,  C12N9/93 ,  C12N15/52 ,  C12P7/18 ,  C12P7/42 ,  C12P13/001 ,  C12P13/005 ,  C12Y101/01258 ,  C12Y102/01063 ,  C12Y206/01 ,  C12Y208/03012 ,  C12Y301/02 ,  C12Y305/01062 ,  C12Y602/01005

摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.

公开(公告)号：US09580731B2

公开(公告)日：2017-02-28

申请号：US14138971

申请日：2013-12-23

申请人： INVISTA North America S.á r.l.

发明人： Adriana Leonora Botes ,  Alex Van Eck Conradie ,  Changlin Chen ,  Paul S. Pearlman

IPC分类号： C12P13/00 ,  C12P7/18 ,  C12P7/42 ,  C12P7/44 ,  C12N15/52

CPC分类号： C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1288 ,  C12N9/16 ,  C12N9/80 ,  C12N9/88 ,  C12N9/93 ,  C12P7/18 ,  C12P7/24 ,  C12P7/42 ,  C12P7/44 ,  C12P13/001 ,  C12P13/005 ,  C12Y101/01 ,  C12Y101/01085 ,  C12Y101/01087 ,  C12Y101/01258 ,  C12Y101/01286 ,  C12Y102/01 ,  C12Y102/01003 ,  C12Y102/0101 ,  C12Y102/99006 ,  C12Y203/01032 ,  C12Y203/03013 ,  C12Y203/03014 ,  C12Y206/01 ,  C12Y207/08 ,  C12Y208/03012 ,  C12Y301/02 ,  C12Y305/01062 ,  C12Y401/01043 ,  C12Y402/01033 ,  C12Y402/01036 ,  C12Y402/01114 ,  C12Y602/01005

摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.

摘要翻译： 本文件描述了通过在C7脂肪族中形成一个或两个由羧基，胺或羟基组成的末端官能团，生成庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径 骨架底物。 本文描述的这些途径，代谢工程和培养策略依赖于C1延长酶或与辅酶B生物合成相关的同源物。

公开(公告)号：US20180298410A1

公开(公告)日：2018-10-18

申请号：US15947824

申请日：2018-04-08

申请人： Evonik Degussa GmbH

发明人： Arne SKERRA ,  Julia MARTIN ,  Harald JAKOB ,  Daniel FISCHER

IPC分类号： C12P11/00

CPC分类号： C12P11/00 ,  C12P7/42 ,  C12Y101/01 ,  C12Y101/01258 ,  C12Y117/01 ,  C12Y401/01001 ,  C12Y401/01043 ,  C12Y401/01072

摘要： The invention relates to an enzymatic method for producing 2-hydroxy-4-methylmercaptobutanoic acid from 3-methylthio-propanal (3-methylmercaptopropanal (MMP) or “methional”) and carbon dioxide.

公开(公告)号：US20170204420A1

公开(公告)日：2017-07-20

申请号：US15405514

申请日：2017-01-13

申请人： INVISTA North American S.á r.I.

发明人： Adriana Leonora Botes ,  Alex Van Eck Conradie ,  Changlin Chen ,  Paul S. Pearlman

IPC分类号： C12N15/52 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12P7/24 ,  C12N9/02 ,  C12N9/00 ,  C12N9/80 ,  C12P7/44 ,  C12P13/00 ,  C12N9/04 ,  C12N9/16

CPC分类号： C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1288 ,  C12N9/16 ,  C12N9/80 ,  C12N9/88 ,  C12N9/93 ,  C12P7/18 ,  C12P7/24 ,  C12P7/42 ,  C12P7/44 ,  C12P13/001 ,  C12P13/005 ,  C12Y101/01 ,  C12Y101/01085 ,  C12Y101/01087 ,  C12Y101/01258 ,  C12Y101/01286 ,  C12Y102/01 ,  C12Y102/01003 ,  C12Y102/0101 ,  C12Y102/99006 ,  C12Y203/01032 ,  C12Y203/03013 ,  C12Y203/03014 ,  C12Y206/01 ,  C12Y207/08 ,  C12Y208/03012 ,  C12Y301/02 ,  C12Y305/01062 ,  C12Y401/01043 ,  C12Y402/01033 ,  C12Y402/01036 ,  C12Y402/01114 ,  C12Y602/01005

摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.

公开(公告)号：US20140193863A1

公开(公告)日：2014-07-10

申请号：US14138971

申请日：2013-12-23

申请人： INVISTA North America S.á r.I.

发明人： Adriana Leonora Botes ,  Alex Van Eck Conradie ,  Changlin Chen ,  Paul S. Pearlman

IPC分类号： C12P13/00 ,  C12P7/42 ,  C12P7/18 ,  C12P7/44

CPC分类号： C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1288 ,  C12N9/16 ,  C12N9/80 ,  C12N9/88 ,  C12N9/93 ,  C12P7/18 ,  C12P7/24 ,  C12P7/42 ,  C12P7/44 ,  C12P13/001 ,  C12P13/005 ,  C12Y101/01 ,  C12Y101/01085 ,  C12Y101/01087 ,  C12Y101/01258 ,  C12Y101/01286 ,  C12Y102/01 ,  C12Y102/01003 ,  C12Y102/0101 ,  C12Y102/99006 ,  C12Y203/01032 ,  C12Y203/03013 ,  C12Y203/03014 ,  C12Y206/01 ,  C12Y207/08 ,  C12Y208/03012 ,  C12Y301/02 ,  C12Y305/01062 ,  C12Y401/01043 ,  C12Y402/01033 ,  C12Y402/01036 ,  C12Y402/01114 ,  C12Y602/01005

摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.

摘要翻译： 本文件描述了通过在C7脂肪族中形成一个或两个由羧基，胺或羟基组成的末端官能团，生成庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径 骨架底物。 本文描述的这些途径，代谢工程和培养策略依赖于C1延长酶或与辅酶B生物合成相关的同源物。

公开(公告)号：US20140193861A1

公开(公告)日：2014-07-10

申请号：US14138827

申请日：2013-12-23

申请人： INVISTA North America S.á.r.l.

发明人： Adriana Leonora Botes ,  Alex Van Eck Conradie ,  Changlin Chen ,  Paul S. Pearlman

IPC分类号： C12P13/00 ,  C12P7/42 ,  C12P7/18 ,  C12P7/44

CPC分类号： C12P7/44 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1096 ,  C12N9/13 ,  C12N9/16 ,  C12N9/80 ,  C12N9/93 ,  C12N15/52 ,  C12P7/18 ,  C12P7/42 ,  C12P13/001 ,  C12P13/005 ,  C12Y101/01258 ,  C12Y102/01063 ,  C12Y206/01 ,  C12Y208/03012 ,  C12Y301/02 ,  C12Y305/01062 ,  C12Y602/01005

摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.

摘要翻译： 本文件描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团，生成庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇的生化途径， 草酸盐或苯甲酸盐。 本文描述的这些途径，代谢工程和培养策略依赖于厌氧苯甲酰辅酶A降解途径酶。