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公开(公告)号：US20140080966A1
公开(公告)日：2014-03-20
申请号：US14081263
申请日：2013-11-15
Applicant: LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Nini H. KJUS , Geir FONNUM , Bruce BRANCHAUD , Lai-Qiang Ying , Steven M. MENCHEN , Dmitriy GREMYACHINSKIY , Hee Chol KANG
IPC: C07F7/10 , C08K3/20 , C08F236/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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公开(公告)号：US09062079B2
公开(公告)日：2015-06-23
申请号：US13762489
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/18 , C07F7/10 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
Abstract translation: 描述了甲硅烷基保护的二丙烯酰胺化合物。 形成这种化合物的方法包括在第一反应条件下将甲硅烷基化试剂与羟基化二胺化合物混合以在第一溶液中形成产物，将产物与第一溶液分离，并在第二反应条件下将产物与丙烯酰氯混合 形成甲硅烷基保护的二丙烯酰胺化合物的第二溶液。
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公开(公告)号：US09828453B2
公开(公告)日：2017-11-28
申请号：US15212532
申请日：2016-07-18
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini Hofslokken Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08F230/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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公开(公告)号：US20140073756A1
公开(公告)日：2014-03-13
申请号：US14081224
申请日：2013-11-15
Applicant: LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Nini H. KJUS , Geir FONNUM , Bruce BRANCHAUD , Lai-Qiang Ying , Steven M. MENCHEN , Dmitriy GREMYACHINSKIY , Hee Chol KANG
IPC: C07F7/18 , C08F236/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
Abstract translation: 描述了甲硅烷基保护的二丙烯酰胺化合物。 形成这种化合物的方法包括在第一反应条件下将甲硅烷基化试剂与羟基化二胺化合物混合以在第一溶液中形成产物，将产物与第一溶液分离，并在第二反应条件下将产物与丙烯酰氯混合 形成甲硅烷基保护的二丙烯酰胺化合物的第二溶液。
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公开(公告)号：US09422384B2
公开(公告)日：2016-08-23
申请号：US14745815
申请日：2015-06-22
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini Hofslokken Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08F230/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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Patent Agency Ranking
公开(公告)号：US09067954B2
公开(公告)日：2015-06-30
申请号：US14081263
申请日：2013-11-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini H. Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08L9/00 , C08F230/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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公开(公告)号：US09062080B2
公开(公告)日：2015-06-23
申请号：US14081224
申请日：2013-11-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini H. Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08F236/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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公开(公告)号：US20180202936A1
公开(公告)日：2018-07-19
申请号：US15923262
申请日：2018-03-16
Applicant: Life Technologies Corporation
Inventor： Hee Chol Kang , Kyle Gee , Bhaskar Mandavilli , Lai-Qiang Ying , Bruce Branchaud
CPC classification number: G01N21/6486 , C09B23/06 , C09B23/08 , C09B23/083 , C09B57/00
Abstract: The present invention is directed to compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
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公开(公告)号：US11731982B2
公开(公告)日：2023-08-22
申请号：US16366908
申请日：2019-03-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Lai-Qiang Ying , Bruce Branchaud , Yu-Zhong Zhang , Stephen Yue
IPC: G01N33/567 , C07D495/04 , C08B37/00 , G01N33/532 , G01N33/543 , B01D15/38 , G01N33/53 , G01N33/554 , G01N33/569 , C07K16/00 , G01N33/58 , C07D403/12 , C07K1/13 , C07K1/22 , C07K16/42 , C09B11/24 , C09K11/06 , C12N5/0783 , G01N33/533 , G01N33/68 , A61K39/00
CPC classification number: C07D495/04 , B01D15/3823 , C07D403/12 , C07K1/13 , C07K1/22 , C07K16/00 , C07K16/42 , C08B37/00 , C09B11/24 , C09K11/06 , C12N5/0636 , C12N5/0637 , C12N5/0638 , G01N33/53 , G01N33/532 , G01N33/533 , G01N33/54353 , G01N33/554 , G01N33/569 , G01N33/58 , G01N33/582 , G01N33/6803 , A61K2039/625 , C07B2200/11 , C07K2317/20 , C07K2317/92 , C09K2211/1007 , C09K2211/1088
Abstract: Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives.
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公开(公告)号：US20130211119A1
公开(公告)日：2013-08-15
申请号：US13762489
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Nini Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/18
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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