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    Method and apparatus for non-destructive screening of specimen integrity
    1.
    发明授权
    Method and apparatus for non-destructive screening of specimen integrity 失效
    无损检测样品完整性的方法和装置

    公开(公告)号：US06353471B1

    公开(公告)日：2002-03-05

    申请号：US08871606

    申请日：1997-06-09

    Applicant: James Samsoondar ,  Merrit Nyles Jacobs

    Inventor： James Samsoondar ,  Merrit Nyles Jacobs

    IPC: G01N3348

    CPC classification number: G01N21/359 ,  G01N21/31

    Abstract: A method and apparatus for providing a non-destructive pre-test screen of specimen integrity for a blood analyzer by measurement of absorbance or reflectance is provided. The method involves measurement of polychromatic light in the near infrared and adjacent visible region, which is either transmitted or reflected from a specimen as presented for measurement, and correlation of the measurement, on the basis of predetermined algorithms, to the quantity of a known substance contained in the sample. The apparatus employs a spectrophotometer which emits radiation which is split into a beam which passes to a sample and a reference beam, the beam returning from the sample and the reference beam are variably combined and further separated into various components by means of a grating and focused onto a linear array detector. A microprocessor receives output from the array detector and performs calculations of concentration(s) of the known substance(s). The invention provides quality assurance for state-of-the art blood analyzers and automated laboratories by pre-screening serum and plasma integrity, even where labels on the sample container would normally interfere with a quality assurance assessment, identifying samples not suitable for certain blood tests, or, if tests are conducted on specimens with compromised integrity, the pre-screening results will aid in the interpretation of the test results.

    Abstract translation: 提供了一种用于通过测量吸光度或反射率来提供用于血液分析仪的样品完整性的非破坏性预测试屏幕的方法和装置。 该方法包括测量近红外和相邻可见区域中的多色光，其被透射或从样品反射出来，用于测量，以及基于预定算法的测量与已知物质的量的相关性 包含在样品中。 该装置采用分光光度计，其发射辐射，其被分成通过样品和参考光束的光束，从样品返回的光束和参考光束可变地组合，并通过光栅进一步分离成各种部件并聚焦 到线性阵列检测器。 微处理器从阵列检测器接收输出并执行已知物质浓度的计算。 本发明通过预先筛选血清和血浆完整性来提供最先进的血液分析仪和自动化实验室的质量保证，即使样品容器上的标签通常会干扰质量保证评估，鉴定不适合某些血液检测的样品 ，或者如果对具有完整性妥协的标本进行测试，则预筛选结果将有助于解释测试结果。

    Immunoassay including washing a slide at different locations
    2.
    发明授权
    Immunoassay including washing a slide at different locations 失效
    免疫测定，包括在不同位置洗涤载玻片

    公开(公告)号：US5641688A

    公开(公告)日：1997-06-24

    申请号：US470100

    申请日：1995-06-06

    Applicant: Merrit Nyles Jacobs

    Inventor： Merrit Nyles Jacobs

    IPC: G01N33/543 ,  G01N35/02 ,  G01N21/00 ,  G01N31/22 ,  G01N33/53

    CPC classification number: G01N33/54386 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S436/808

    Abstract: A method of separating bound labeled indicator from free labeled indicator in a layer of a test element for immunoassay. The method comprisesa) depositing sample containing a target immunoanalyte capable of binding to the labeled indicator or to an immobilized antibody in competition with the labeled indicator, onto an exterior surface of a test element in the presence of the labeled indicator andb) adding an amount of wash liquid to the exterior surface to form a pool of the liquid having a meniscus on the surface, the liquid penetrating the surface over an area bounded by a closed intersect edge formed between the pool meniscus and the surface, so that penetrating liquid can push free labeled indicator away from bound labeled indicator in a volume of the layer below the bounded area. The method is improved in that the step b) comprises i) depositing a first amount of wash liquid at a first location on the surface in a pool, (ii) allowing at least a portion of the pool to spread out through a first portion of the test element to wash out free labeled indicator, and then (iii) depositing a second amount of wash liquid at a second location on the surface different from the first location to spread out through a second portion of the test element different from the first portion, so that the intersect edge is displaced over the surface over time and the liquid flowing into the test element at the intersect edge sweeps through more of the target read area than is the case when washing from only the first location, thus reducing background signal due to non-separated free labeled indicator remaining in the volume.

    Abstract translation: 用于免疫测定的测试元件层中的结合标记指示剂与游离标记指示剂分离的方法。 该方法包括a）在标记的指示剂的存在下，将含有能够结合标记的指示剂的靶免疫分析物或与标记的指示剂竞争的固定的抗体沉积到测试元件的外表面上，并且b） 洗涤液体到外表面的量，以形成在表面上具有弯液面的液体池，液体在由弯液面和表面之间形成的封闭相交边界限定的区域上穿透表面，使得穿透液体 在有界区域以下的层的体积中将免费标记的指示符远离绑定的标记指示符。 改进方法是，步骤b）包括：i）在池中的表面上的第一位置处沉积第一量的洗涤液体，（ii）允许池的至少一部分通过第一部分的 洗涤游离标记的指示剂的测试元件，然后（iii）在不同于第一位置的表面上的第二位置沉积第二量的洗涤液体，以通过不同于第一部分的测试元件的第二部分展开 ，使得相交边缘随着时间的推移在表面上移位，并且在相交边缘处流入测试元件的液体比仅从第一位置洗涤的情况下扫过更多的目标读取区域，从而减少背景信号 到体积中剩余的未分离的游离标记指示物。

    Incremental absorbance scanning of liquid in dispensing tips
    3.
    发明授权
    Incremental absorbance scanning of liquid in dispensing tips 失效
    分配尖端液体的增量吸光度扫描

    公开(公告)号：US06235534B1

    公开(公告)日：2001-05-22

    申请号：US09264806

    申请日：1999-03-09

    Applicant: Ronald Frederich Brookes ,  Merrit Nyles Jacobs ,  Alan John Lowne ,  James David Shaw

    Inventor： Ronald Frederich Brookes ,  Merrit Nyles Jacobs ,  Alan John Lowne ,  James David Shaw

    IPC: G01N2100

    CPC classification number: G01N35/1016 ,  G01N2035/1025 ,  Y10T436/119163

    Abstract: A method and apparatus for detecting improper liquid content of a metering tip of an analyzer. The method detects the content or status using radiation between 630 and 2000 nm, and comprises the steps of: a) aspirating the liquid into the tips; b) scanning the liquid; c) providing relative motion between the tip and the scanner while simultaneously scanning the liquid; d) detecting the amount of light transmitted to detector at all levels of the liquid; e) comparing the detected light with light known to be transmitted at levels of liquid free of air bubbles; and flagging the results.

    Abstract translation: 一种用于检测分析仪的计量尖端的不适当液体含量的方法和装置。 该方法使用630〜2000nm之间的辐射来检测内容或状态，包括以下步骤：a）将液体吸入尖端; b）扫描液体; c）在同时扫描液体的同时提供尖端和扫描仪之间的相对运动; d）检测在各液位下传输到检测器的光量; e）将检测到的光与已知以不含气泡的液体水平传播的光进行比较; 并标记结果。

    Apparatus for controlling humidity
    4.
    发明授权
    Apparatus for controlling humidity 失效
    湿度控制装置

    公开(公告)号：US5715611A

    公开(公告)日：1998-02-10

    申请号：US734058

    申请日：1996-10-18

    Applicant: Merrit Nyles Jacobs ,  Roger G. Leighton ,  John J. Meyers

    Inventor： Merrit Nyles Jacobs ,  Roger G. Leighton ,  John J. Meyers

    IPC: F26B21/08 ,  F26B19/00

    CPC classification number: F26B21/083

    Abstract: Humidity control apparatus for articles being stored, comprising: a) a chamber within which the articles are to be contained, b) a conveyor passing by a portion of, and exposed to, the contents of the chamber, c) a drive mechanism for driving the conveyor past the portion of the chamber, d) a desiccant on the conveyor, e) a humidistat positioned to measure the water vapor content within the chamber, and f) a control mechanism operatively connecting the humidistat and the drive mechanism for advancing fresh desiccant past the chamber when the water vapor content of the chamber is too high.

    Abstract translation: 存储物品的湿度控制装置，包括：a）容纳物品的室，b）通过所述室的内容物的一部分并暴露于其中的输送器，c）用于驱动的​​驱动机构 传送带经过室的部分，d）在输送机上的干燥剂，e）定位成测量室内的水蒸汽含量的湿度计，以及f）可操作地连接湿度计和驱动机构以控制新鲜干燥剂的控制机构 当房间的水蒸汽含量过高时，通过室。

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