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1.发明申请公开(公告)号：US20090203648A1
公开(公告)日：2009-08-13
申请号：US12385614
申请日：2009-04-14
申请人： Bruno Bujoli , Solen Josse , Jerome Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
发明人： Bruno Bujoli , Solen Josse , Jerome Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
IPC分类号： A61K31/675 , C07F9/06 , C07F9/58 , C07F9/6506 , A61K31/661 , A61P19/10
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
摘要翻译： 由双膦酸或其一种盐改性的磷酸化合物，其制备方法以及其用于制备可注射组合物的用途。 修饰的磷酸钙化合物通过在超纯水中向前体磷酸钙化合物的悬浮液中加入偕 - 二膦酸或其碱金属或碱土金属盐，同时在室温下搅拌反应介质，然后通过 离心形成的化合物。 该化合物可用于制备可注射组合物，用于治疗骨重塑平衡。
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2.发明授权公开(公告)号：US08044037B2
公开(公告)日：2011-10-25
申请号：US12385614
申请日：2009-04-14
申请人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
发明人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
摘要翻译： 由双膦酸或其一种盐改性的磷酸化合物，其制备方法以及其用于制备可注射组合物的用途。 修饰的磷酸钙化合物通过在超纯水中向前体磷酸钙化合物的悬浮液中加入偕 - 二膦酸或其碱金属或碱土金属盐，同时在室温下搅拌反应介质，然后通过 离心形成的化合物。 该化合物可用于制备可注射组合物，用于治疗骨重塑平衡。
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3.发明授权公开(公告)号：US07521436B2
公开(公告)日：2009-04-21
申请号：US10506550
申请日：2003-02-18
申请人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
发明人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
摘要翻译： 本发明涉及由双膦酸或其一种盐改性的磷酸化合物，其制备方法以及其用于制备可注射组合物的用途。 修饰的磷酸钙化合物通过在超纯水中将前体磷酸钙化合物的悬浮液中加入偕 - 双膦酸或其碱金属或碱土金属盐，同时在室温下搅拌反应介质，然后通过 离心形成的化合物。 所述化合物可用于制备可注射组合物，用于治疗骨重塑平衡。
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4.发明申请公开(公告)号：US20050282783A1
公开(公告)日：2005-12-22
申请号：US10506550
申请日：2003-02-18
申请人： Bruno Bujoli , Solen Josse , Jerome Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
发明人： Bruno Bujoli , Solen Josse , Jerome Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
IPC分类号： A61K9/06 , A61K31/663 , A61K33/42 , A61K47/36 , A61K47/38 , A61L27/12 , A61L27/54 , A61P19/10 , A61P35/00 , C07F9/38 , C07F9/6506 , A61K31/675
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
摘要翻译： 本发明涉及由双膦酸或其一种盐改性的磷酸化合物，其制备方法以及其用于制备可注射组合物的用途。 修饰的磷酸钙化合物通过在超纯水中将前体磷酸钙化合物的悬浮液中加入偕 - 双膦酸或其碱金属或碱土金属盐，同时在室温下搅拌反应介质，然后通过 离心形成的化合物。 所述化合物可用于制备可注射组合物，用于治疗骨重塑平衡。
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公开(公告)号：US09642939B2
公开(公告)日：2017-05-09
申请号：US12438598
申请日：2007-08-23
CPC分类号： A61L27/46 , A61L24/0036 , A61L24/0042 , A61L24/0063 , A61L24/0084 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.
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公开(公告)号：US20120111226A1
公开(公告)日：2012-05-10
申请号：US13255069
申请日：2010-03-03
申请人： Bruno Bujoli , Jean-Michel Bouler , Pascal Janvier , Ibrahim Khairoun , Verena Schnitzler , Charlotte Mellier
发明人： Bruno Bujoli , Jean-Michel Bouler , Pascal Janvier , Ibrahim Khairoun , Verena Schnitzler , Charlotte Mellier
IPC分类号： C04B12/02
CPC分类号： A61L24/0042 , A61L24/0063 , A61L27/12 , A61L27/46 , A61L27/58 , C01B25/32 , C01B25/45 , C04B35/447
摘要： The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): Ca(005-1 5X)Gax(PO—O4)7, wherein 0
摘要翻译： 本发明涉及包含式（I）的掺杂镓的磷酸钙化合物：Ca（005-1 5X）Gax（PO-O4）7，其中0
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公开(公告)号：US20120064170A1
公开(公告)日：2012-03-15
申请号：US13255076
申请日：2010-03-03
CPC分类号： A61L24/0042 , A61L24/0063 , A61L27/12 , A61L27/46 , A61L27/58 , C01B25/32 , C01B25/45 , C04B35/447
摘要： The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7, wherein 0
摘要翻译： 本发明涉及式（I）的掺杂镓的磷酸钙化合物：Ca（10.5-1.5x）Gax（PO4）7，其中0
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8.发明授权公开(公告)号：US08889165B2
公开(公告)日：2014-11-18
申请号：US12031562
申请日：2008-02-14
CPC分类号： A61L27/12 , A61L24/001 , A61L24/0063 , A61L24/02 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
摘要翻译： 本发明涉及一种具有高抗压强度的大孔，可吸收和可注射的磷酸钙水泥，其可用作骨水泥并释放骨吸收抑制剂，其制备方法和用途。
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公开(公告)号：US20140087004A1
公开(公告)日：2014-03-27
申请号：US14094314
申请日：2013-12-02
IPC分类号： A61K33/42
CPC分类号： A61K33/42 , A61K6/033 , A61K6/0643 , A61L27/12 , A61L27/32 , C01B25/32 , C01B25/45 , C04B12/02 , C04B28/34 , C04B35/447 , C04B2111/00836 , C04B2235/3208 , C04B2235/3212 , C04B2235/3286 , C04B2235/44 , C04B2235/442 , C04B2235/443 , C04B2235/444 , C04B2235/445 , C04B2235/448 , C04B2235/449 , C04B2235/76 , C04B2235/761 , A61K6/02
摘要： The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5−1.5x)Gax(PO4)7 (I) wherein 0
摘要翻译： 本发明涉及式（I）的掺杂镓的磷酸钙化合物：其中0
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公开(公告)号：US08623311B2
公开(公告)日：2014-01-07
申请号：US12716862
申请日：2010-03-03
IPC分类号： C01B25/32
CPC分类号： A61K33/42 , A61K6/033 , A61K6/0643 , A61L27/12 , A61L27/32 , C01B25/32 , C01B25/45 , C04B12/02 , C04B28/34 , C04B35/447 , C04B2111/00836 , C04B2235/3208 , C04B2235/3212 , C04B2235/3286 , C04B2235/44 , C04B2235/442 , C04B2235/443 , C04B2235/444 , C04B2235/445 , C04B2235/448 , C04B2235/449 , C04B2235/76 , C04B2235/761 , A61K6/02
摘要： The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7 (I) wherein 0
摘要翻译： 本发明涉及式（I）的掺杂镓的磷酸钙化合物：其中0
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