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公开(公告)号：US08440462B2
公开(公告)日：2013-05-14
申请号：US12785874
申请日：2010-05-24
申请人： Pierre Weiss , Jérôme Guicheux , Guy Daculsi , Gaël Grimandi , Claire Vinatier
发明人： Pierre Weiss , Jérôme Guicheux , Guy Daculsi , Gaël Grimandi , Claire Vinatier
IPC分类号： C12N5/00
CPC分类号： C12N5/0655 , A61L27/3817 , A61L27/3852 , C12N2533/30
摘要： The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.
摘要翻译： 本发明涉及用于三维离体培养软骨细胞的硅烷化羟丙基甲基纤维素（HPMC）或硅烷化羟乙基纤维素（HEC）水凝胶，其自交联作为pH的函数。
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2.发明授权Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment 有权用于骨修复，增生，再生和骨质疏松症治疗的大孔，可吸收和可注射的磷酸钙基水泥（MCPC）公开(公告)号：US07351280B2
公开(公告)日：2008-04-01
申请号：US11054623
申请日：2005-02-09
申请人： Ibrahim Khairoun , Racquel Z. LeGeros , Guy Daculsi , Jean-Michael Bouler , Jérôme Guicheux , Olivier Gauthier
发明人： Ibrahim Khairoun , Racquel Z. LeGeros , Guy Daculsi , Jean-Michael Bouler , Jérôme Guicheux , Olivier Gauthier
IPC分类号： C04B12/02
CPC分类号： C04B28/344 , A61L24/02 , A61L27/12 , A61L2430/02 , C04B2111/00836 , C04B11/00 , C04B14/28 , C04B20/0076 , C04B38/0051 , C04B2103/0072
摘要： A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.
摘要翻译： 互连大孔，可吸收和可注射的磷酸钙基水泥（MICPC）的组合物和方法。 本发明的组合物在混合粉末组分和水溶液之后设定为不良结晶的磷灰石磷酸钙。 水泥中的多相磷酸钙组分以不同的速率吸收，允许及时更换新骨。 水泥中相互连接的大孔隙可以使血管形成，生长因子的截留，细胞定植和组织向内生长。 该MICPC可用于与骨修复，增强，重建，再生和骨质疏松症治疗以及用于药物递送以及组织工程支架相关的牙科和医疗应用。
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公开(公告)号：US20100297764A1
公开(公告)日：2010-11-25
申请号：US12785874
申请日：2010-05-24
申请人： Pierre Weiss , Jérôme Guicheux , Guy Daculsi , Gaël Grimandi , Claire Vinatier
发明人： Pierre Weiss , Jérôme Guicheux , Guy Daculsi , Gaël Grimandi , Claire Vinatier
IPC分类号： C12N5/077
CPC分类号： C12N5/0655 , A61L27/3817 , A61L27/3852 , C12N2533/30
摘要： The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.
摘要翻译： 本发明涉及用于三维离体培养软骨细胞的硅烷化羟丙基甲基纤维素（HPMC）或硅烷化羟乙基纤维素（HEC）水凝胶，其自交联作为pH的函数。
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公开(公告)号：US09968681B2
公开(公告)日：2018-05-15
申请号：US14123286
申请日：2012-06-04
CPC分类号： A61K47/38 , A61K35/28 , A61K35/34 , A61K2035/124 , C12N5/0068 , C12N5/0657 , C12N2533/20 , C12N2533/72 , C12N2533/78
摘要： The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.
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5.发明申请SILYLATED BIOMOLECULE-BASED HYDROGEL FOR CULTURING CARDIOMYOCYTES AND STEM CELLS, AND USE OF THE HYDROGEL THEREOF FOR TREATING HEART FAILURE 有权用于培养心肌细胞和干细胞的SILYLATED生物分子水凝胶，以及其用于治疗心脏衰竭的水凝胶的使用公开(公告)号：US20140161775A1
公开(公告)日：2014-06-12
申请号：US14123286
申请日：2012-06-04
CPC分类号： A61K47/38 , A61K35/28 , A61K35/34 , A61K2035/124 , C12N5/0068 , C12N5/0657 , C12N2533/20 , C12N2533/72 , C12N2533/78
摘要： The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.
摘要翻译： 本发明涉及含有甲硅烷基化生物分子的水凝胶用于能够分化成心肌细胞的心肌细胞或干细胞的三维培养物，以及包含i）心肌细胞或干细胞的水性组合物的用途，所述心肌细胞或干细胞能够分化为 心肌细胞，和ii）包含甲硅烷基化生物分子的水凝胶，用于治疗心力衰竭，特别是心肌梗塞后的心力衰竭。
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6.发明授权公开(公告)号：US08044037B2
公开(公告)日：2011-10-25
申请号：US12385614
申请日：2009-04-14
申请人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
发明人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
摘要翻译： 由双膦酸或其一种盐改性的磷酸化合物，其制备方法以及其用于制备可注射组合物的用途。 修饰的磷酸钙化合物通过在超纯水中向前体磷酸钙化合物的悬浮液中加入偕 - 二膦酸或其碱金属或碱土金属盐，同时在室温下搅拌反应介质，然后通过 离心形成的化合物。 该化合物可用于制备可注射组合物，用于治疗骨重塑平衡。
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7.发明授权公开(公告)号：US07521436B2
公开(公告)日：2009-04-21
申请号：US10506550
申请日：2003-02-18
申请人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
发明人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
摘要翻译： 本发明涉及由双膦酸或其一种盐改性的磷酸化合物，其制备方法以及其用于制备可注射组合物的用途。 修饰的磷酸钙化合物通过在超纯水中将前体磷酸钙化合物的悬浮液中加入偕 - 双膦酸或其碱金属或碱土金属盐，同时在室温下搅拌反应介质，然后通过 离心形成的化合物。 所述化合物可用于制备可注射组合物，用于治疗骨重塑平衡。
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