发明授权
US07521436B2 Modified phosphocalcic compound, injectable composition containing same
有权
改性磷酸钙化合物,含有其的可注射组合物
- 专利标题: Modified phosphocalcic compound, injectable composition containing same
- 专利标题(中): 改性磷酸钙化合物,含有其的可注射组合物
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申请号: US10506550申请日: 2003-02-18
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公开(公告)号: US07521436B2公开(公告)日: 2009-04-21
- 发明人: Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
- 申请人: Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
- 申请人地址: FR Paris FR Nantes FR Paris
- 专利权人: Centre National de la Recherche Scientifique,Universite de Nantes,Institut National de la Sante et de la Recherche Medicale
- 当前专利权人: Centre National de la Recherche Scientifique,Universite de Nantes,Institut National de la Sante et de la Recherche Medicale
- 当前专利权人地址: FR Paris FR Nantes FR Paris
- 代理机构: Buchanan Ingersoll & Rooney PC
- 优先权: FR0202707 20020304
- 国际申请: PCT/FR03/00527 WO 20030218
- 国际公布: WO03/074098 WO 20030912
- 主分类号: A61K31/66
- IPC分类号: A61K31/66 ; C07F9/02
摘要:
The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
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