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公开(公告)号：US20250026862A1
公开(公告)日：2025-01-23
申请号：US18712740
申请日：2022-11-24
Applicant: Kemira Oyj
Inventor： Erkki Johannes METSÄLÄ
Abstract: The disclosure relates to a method for producing anionic saccharides by reacting saccharide with a compound having a conjugated electron withdrawing group via oxa-Michael addition reaction for producing a derivatized saccharide followed by anionizing the derivatized saccharide. The disclosure further relates to anionic saccharides and to use of the anionic saccharides, for example, as flocculants in waste water treatment, as an agent on enhanced oil recovery and as an agent in paper industry.
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公开(公告)号：US20240417418A1
公开(公告)日：2024-12-19
申请号：US18702855
申请日：2022-10-21
Inventor： Jorge Moreno Herrero , Heinrich Haas , Stephanie Erbar , José Manuel García Fernández , Juan Manuel Benito Hernández , Jose Lopez Fernandez , Práxedes Sánchez Mellado
IPC: C07H15/04 , A61K9/00 , A61K31/7105 , A61K47/54 , C07H1/00
Abstract: The present disclosure provides compounds, compositions, and complexes useful for delivery of certain agents, including, for example, nucleic acids.
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公开(公告)号：US12162901B2
公开(公告)日：2024-12-10
申请号：US17491518
申请日：2021-09-30
Applicant: The Regents of the University of California
Inventor： Xi Chen , An Xiao , Anoopjit Kooner , Abhishek Santra , Ajit Varki , Hai Yu , Lee-Ping Wang , Wanqing Li
Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
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公开(公告)号：US20240400601A1
公开(公告)日：2024-12-05
申请号：US18700569
申请日：2022-10-12
Inventor： Estelle ILLOUS , Stéphane DESSILLA
Abstract: Disclosed is a process for preparing alkyl polyglycosides having a color of less than or equal to 1.5 VCS, the process successively involving: a) a glycosylation step a) consisting in a reaction between at least one alcohol of formula (I) and at least one reducing sugar of formula (III): H—O-(G)-H (III), in the presence of at least one acid catalyst (CA) at a minimum temperature of 100° C. and a maximum temperature of 120° C., b) a step b) of neutralizing the reaction medium from step a) with an aqueous solution comprising a basic agent (Ab), c) a step c) of removing the sugar of formula (III), which has not reacted in step a), from the neutralized reaction medium, and d) a step d) of recovering at least one composition (C) having a color of less than or equal to 1.5 VCS.
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公开(公告)号：US12135325B2
公开(公告)日：2024-11-05
申请号：US17024913
申请日：2020-09-18
Inventor： Mark Nitz , Landon J. Edgar , Bradly G. Wouters , David Hedley , Lisa M. Willis , Matthew A. Lumba , Hanuel Park , Ravi N. Vellanki
IPC: C07D345/00 , C07D421/06 , C07H15/04 , G01N33/569 , G01N33/58
Abstract: A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.
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Patent Agency Ranking
公开(公告)号：US12116573B2
公开(公告)日：2024-10-15
申请号：US17184575
申请日：2021-02-24
Applicant: Arrowhead Pharmaceuticals, Inc.
Inventor： David B. Rozema , Darren H. Wakefield , Andrei V. Blokhin , Jonathan D. Benson , Zhen Li , Tao Pei , Fred Fleitz
IPC: C12N15/113 , A61K31/713 , A61K47/54 , C07H15/04
CPC classification number: C12N15/113 , A61K31/713 , A61K47/549 , C07H15/04 , C12N2310/14 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2310/3515 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533 , C12N2310/322 , C12N2310/3525
Abstract: Described are novel targeting ligands that may be linked to compounds, such therapeutic compounds, that are useful in directing the compounds to the target in vivo. The targeting ligands disclosed herein can serve to target expression-inhibiting oligomeric compounds, such as RNAi agents, to liver cells to modulate gene expression. The targeting ligands disclosed herein, when conjugated to an expression-inhibiting oligomeric compound, may be used in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Compositions including the targeting ligands disclosed herein when linked to expression-inhibiting oligomeric compounds are capable of mediating expression of target nucleic acid sequences in liver cells, such as hepatocytes, which may be useful in the treatment of diseases or conditions that respond to inhibition of gene expression or activity in a cell, tissue, or organism.
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公开(公告)号：US20240284943A1
公开(公告)日：2024-08-29
申请号：US18656578
申请日：2024-05-06
Applicant: ZHEJIANG HUAKANG PHARMACEUTICAL CO., LTD.
Inventor： Baoxing MAO , Ling WAN , Jingjing XU , Zhihui YAO , Bo XU , Hang YUE , Fuan WAN
Abstract: The present disclosure relates to a method for preventing crystal maltitol from caking in storage, comprising: detecting a temperature and a humidity of a dried crystal maltitol on-line in real time, an on-line temperature and humidity meter being configured to set a sieving and packaging treatment condition, a redrying treatment condition, and an aging treatment condition; performing a sieving and packaging treatment on the crystal maltitol whose temperature and humidity satisfy the sieving and packaging treatment condition, performing a redrying treatment or an aging treatment on the crystal maltitol whose temperature and humidity satisfy the redrying treatment condition or the aging treatment condition; detecting a temperature and a humidity of the crystal maltitol after the redrying treatment or the aging treatment, and performing the sieving and packaging treatment after the crystal maltitol on the crystal maltitol whose temperature and humidity satisfy the sieving and packaging treatment condition, or else continuing with the redrying treatment or the aging treatment.
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公开(公告)号：US20240018177A1
公开(公告)日：2024-01-18
申请号：US18208629
申请日：2023-06-12
Inventor： Andrea Choe , Paul W. Sternberg , Frank C. Schroeder , Stephan H. von Reuss
IPC: C07H15/04 , A61K31/7028 , A01N37/36 , A61K31/454 , C07H15/08 , C07H15/10 , C07H15/18 , C07H15/26 , A01N43/16 , A01N43/38
CPC classification number: C07H15/04 , A61K31/7028 , A01N37/36 , A61K31/454 , C07H15/08 , C07H15/10 , C07H15/18 , C07H15/26 , A01N43/16 , A01N43/38 , C07D309/10
Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
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公开(公告)号：US20230374056A1
公开(公告)日：2023-11-23
申请号：US18248092
申请日：2021-10-07
Applicant: Petroliam Nasional Berhad (PETRONAS)
Inventor： Sara SHAHRUDDIN , Navin SHARMA KARAM CHAND , Siti Fatihah SALLEH , Jofry OTHMAN , Nur Amalina SAMSUDIN
IPC: C07H15/04
CPC classification number: C07H15/04
Abstract: Provided are methods and systems for the production of alkyl polyglucoside. The methods and systems provide for improved purification that results in reduced produce degradation.
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公开(公告)号：US20230357301A1
公开(公告)日：2023-11-09
申请号：US18332157
申请日：2023-06-09
Applicant: Faculdade de Ciencias da Universidade de Lisboa , Instituto de Tecnologia Quimica e Biologica Antonio Xavier
Inventor： Christopher David Maycock , Maria Rita Mendes Bordalo Ventura Centeno Lima , Eva Correia Lourenco , Maria Helena Dias dos Santos , Ana Sofia da Cunha Miguel
Abstract: A compound of formula I:
or a salt thereof, wherein:
R1 is —OC (H) (X) (CH2)nC(═O)OH;
R2 is —OH, —N3, or —N(H)C(═O)CH3; or
R1 and R2 together with the carbon atoms to which they are attached form
R3 is —H, —CH3, —CH2C(═O)OH, or —CH2OH;
X is —H, —CH3, —CH2OH, or CH2C(═O)OH; and n is 0 or 1.
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