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公开(公告)号：US20250018027A1
公开(公告)日：2025-01-16
申请号：US18713083
申请日：2022-11-25
Inventor： Luis ENJUANES SÁNCHEZ , Isabel SOLA GURPEGUI , Sonia ZÚÑIGA LUCAS , Francisco Javier GUTIERREZ ALVAREZ , Melissa LORETO BELLÓ-PÉREZ , José Manuel HONRUBIA BELENGUER
IPC: A61K39/215 , A61K39/00 , A61P31/14 , C12N7/00
Abstract: A propagation-defective, replication-competent RNA replicon derived from the SARS-CoV-2 coronavirus that comprises a polynucleotide sequence SEQ_ID 2 or a variant of SEQ_ID 2 having at least 80% identity, more preferably 85% identity, even more preferably at least 90% identity, and even more preferably 91% or 92% or 93% or 94% or 95% or 96% or 97% or 98% or even up to 99% identity with respect to the SEQ_ID 2 polynucleotide sequence, wherein the variant of SEQ_ID2 does not comprise sequences suitable for expressing an ORF8 protein, wherein the ORF8 protein is encoded by a gene having at least 80% identity to the sequence of SEQ_ID36, methods of preparation thereof and the use in vaccine compositions.
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公开(公告)号：US20240417418A1
公开(公告)日：2024-12-19
申请号：US18702855
申请日：2022-10-21
Inventor： Jorge Moreno Herrero , Heinrich Haas , Stephanie Erbar , José Manuel García Fernández , Juan Manuel Benito Hernández , Jose Lopez Fernandez , Práxedes Sánchez Mellado
IPC: C07H15/04 , A61K9/00 , A61K31/7105 , A61K47/54 , C07H1/00
Abstract: The present disclosure provides compounds, compositions, and complexes useful for delivery of certain agents, including, for example, nucleic acids.
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3.发明公开公开(公告)号：US20240337619A1
公开(公告)日：2024-10-10
申请号：US18293609
申请日：2022-07-18
Inventor： Josep Maria MARGARIT TAULE , Shih-Chii LIU , Cecilia JIMENEZ JORQUERA
IPC: G01N27/327 , G06N3/0499
CPC classification number: G01N27/3273 , G06N3/0499
Abstract: A neurocomputational electrochemical sensing device (1) is proposed for predicting properties of a substance. The device (1) comprises: a plurality of electrochemical sensors constituting a sensor array (3), the sensors being sensitive to sensed attributes advantageous to predict a set of properties of interest of the substance, each sensor being configured to output a sensor output signal indicative of a sensor response of the respective sensor to measurable changes in the sensed attributes of the substance; a readout circuit (5) for biasing the sensors and for conditioning the sensor output signals into readout circuit output signals to facilitate further processing of the sensor responses; and an artificial neural network processor (7) for processing the readout circuit output signals, the processor (7) comprising neurons interconnected by synapses, the processor (7) being configured to output a set of processor output signals whose signal values are indicative of the properties to predict. The sensor array (3) comprises first electrochemical sensors selective to properties correlated with the desired properties to predict, and second electrochemical sensors sensitive primarily to the main interferents of the substance. The neurons and/or the synapses are configured to be trained to compensate for sensor drift and/or cross-sensitivities upon generating the processor output signals.
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公开(公告)号：US20240278176A1
公开(公告)日：2024-08-22
申请号：US18566897
申请日：2022-05-31
IPC: B01D53/62 , B01D53/96 , C01B3/16 , C01B3/40 , C01B32/50 , C01F11/06 , C04B2/10 , C04B2/12 , F27B1/00 , F27B1/04
CPC classification number: B01D53/62 , B01D53/96 , C01B3/16 , C01B3/40 , C01B32/50 , C01F11/06 , C04B2/108 , C04B2/12 , F27B1/005 , F27B1/04 , B01D2251/404 , B01D2257/504 , B01D2258/0233 , B01D2258/0283 , C01B2203/0233 , C01B2203/0283 , C01B2203/1058 , C01B2203/1076 , F27M2003/03
Abstract: This invention discloses a calcination process to produce high purity CO2 from solids containing CaCO3 which operates cyclically and continuously on the solids, arranged in a packed or a moving bed, and wherein each cycle comprises a first step where the combustion at atmospheric pressure of a fuel in the bed of solids containing CaCO3 heats them up to 800-900° C. and a second step wherein a vacuum pressure between 0.05 and 0.5 atm is applied to extract pure CO2 from the solids containing CaCO3 while cooling them by 30-200° C. Said combustion can be carried out directly with air, oxygen enriched air or O2/CO2 mixtures when the process is applied to the calcination of a continuous flow of limestone in a moving bed shaft kiln. The process is also applied to calcine CaCO3 formed in reversible calcium looping processes comprising a carbonation reaction step to form CaCO3 from CaO.
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公开(公告)号：US20240277896A1
公开(公告)日：2024-08-22
申请号：US18568815
申请日：2022-06-09
Applicant: FUNDACIÓ INSTITUT CATALÀ DE NANOCIÈNCIA I NANOTECNOLOGIA (ICN2) , CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)
Inventor： Salvio SUÁREZ GARCÍA , Javier SAIZ POSEU , Daniel RUIZ MOLINA
CPC classification number: A61L27/34 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L27/54 , A61L27/58 , C08G65/4075 , C08G65/48 , C08G73/0206 , C08G73/0213 , C08G73/0253 , C08G2150/00 , C08G2170/80 , C08G2230/00
Abstract: The present invention provides a process for preparing a self-standing catecholamine-based membrane, the process comprising the steps of: (a) cross-linking a catechol derivative with an amine selected from the group consisting of: a known aliphatic amine hydrocarbon of formula (II); and an aromatic amine of formula (IIbis), in a liquid medium, wherein both the catechol and the amine are soluble, at a pH comprised from 6.5 to 10, and under appropriate agitation to create a catecholamine membrane in the air/liquid interface in the absence of any support; and b) isolating the membrane resulting from step (a) from the air/liquid interface. The resulting self-standing catecholamine-based membrane was robust, easy to handle and manipulate, highly flexible and adaptable to any kind of surface without breaking, and adhesive. In addition, the free-standing membrane of the invention shows a Janus character, with an unexpected nanopatterning in the water-contact side which endows the membranes of the invention with a higher roughness surface, something of value to promote cell adhesion.
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Patent Agency Ranking
公开(公告)号：US20240245657A1
公开(公告)日：2024-07-25
申请号：US18563568
申请日：2022-05-23
Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS , ADMINISTRACIÓN GENERAL DE LA COMUNIDAD AUTÓNOMA DE EUSKADI
Inventor： Ana MARTÍNEZ GIL , Valle PALOMO RUIZ , Miren Ametsa SÁENZ PEÑA , Adolfo José LÓPEZ DE MUNAIN ARREGI
IPC: A61K31/433 , A61P21/00
CPC classification number: A61K31/433 , A61P21/00
Abstract: The present invention relates to 2,4-disubstituted thiadiazolidinones of formula (I):
or a pharmaceutically acceptable salt or solvate thereof, for its use in the treatment of limb girdle muscular dystrophy.-
公开(公告)号：US20240165079A1
公开(公告)日：2024-05-23
申请号：US18339174
申请日：2023-06-21
Applicant: Consejo Superior de Investigaciones Científicas (CSIC) , Universidad Autónoma de Madrid , CENTRO DE INVESTIGATIÓN BIOMÉDICA EN RED DE ENFERMEDADES NEURODEGENERATIVAS , Terran Biosciences Inc. , Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
IPC: A61K31/4045 , A61K31/496 , A61K31/498 , A61K31/519 , A61P25/16
CPC classification number: A61K31/4045 , A61K31/496 , A61K31/498 , A61K31/519 , A61P25/16
Abstract: The present application provides a combination product for the treatment and/or prevention of psychiatric and/or neurological disorders. The combination product comprises (i) a compound which promotes neurogenesis and has hallucinogenic and/or psychedelic side effects, and (ii) a 5-HT2A receptor antagonist which alleviates and/or removes the hallucinogenic and/or psychedelic side effects caused by the first compound.
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公开(公告)号：US11982804B2
公开(公告)日：2024-05-14
申请号：US17770893
申请日：2020-10-29
Inventor： Jesús Aceituno Castro , José Luis Ortiz Moreno , Faustino Organero Villajos , John Davenport , Kalaga Madhav , Martin Matthias Thomas Roth
Abstract: It comprises optical assemblies that focus light onto individual first optical fibers which are combined together in a final single optical fiber, collecting a considerable amount of light from a target, to feed an instrument such as a spectrograph. The first optical fibers are kept centred on the target through image devices that also provide images, and these images can be combined to give rise to a high-quality image of the field surrounding the target. The final effective aperture of the device is scalable, using different numbers of optical assemblies and depending on their diameters.
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公开(公告)号：US20240084312A1
公开(公告)日：2024-03-14
申请号：US18269167
申请日：2021-12-20
CPC classification number: C12N15/70 , A61K35/74 , A61P35/00 , C07K14/245 , C07K16/2863 , C12N9/1077 , C12Y204/02036 , A61K2039/523
Abstract: The invention relates to a recombinant bacterium and uses thereof. In particular, it relates to the use of recombinant bacteria to translocate cargo proteins into the cytosol of target cells. Said recombinant bacteria comprises a T3 secretion system under the control of a genetic regulatory circuit and a targeting module which allow the recombinant bacteria to target specific cells, adhere to these and inject their cargo into the cytosol of the target cells.
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10.发明公开公开(公告)号：US20240043374A1
公开(公告)日：2024-02-08
申请号：US18267330
申请日：2021-12-16
Inventor： Agatha BASTIDA CODINA , Raúl BENITO ARENAS , Victor M. BOLANOS-GARCÍA , Natalie Laura CURTIS
IPC: C07C237/20 , C07C237/06 , A61K31/27 , A61P35/00 , A61K31/165
CPC classification number: C07C237/20 , C07C237/06 , A61K31/27 , A61P35/00 , A61K31/165 , C07B2200/09
Abstract: The invention relates to inhibitors of anaphase promoting complex/cyclosome (APC/C) function of formula (I), wherein the meaning for R1 and R2 is as disclosed in the description. These compounds are useful in the treatment of cancer, particularly, in the treatment of breast cancer.
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