-
公开(公告)号：US11161868B2
公开(公告)日：2021-11-02
申请号：US16418758
申请日：2019-05-21
Applicant: The Regents of the University of California
Inventor： Xi Chen , An Xiao , Anoopjit Kooner , Abhishek Santra , Ajit Varki , Hai Yu , Lee-Ping Wang , Wanqing Li
Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
-
公开(公告)号：US10428101B2
公开(公告)日：2019-10-01
申请号：US14897596
申请日：2014-06-16
Applicant: The Regents of the University of California
Inventor： Xi Chen , Hai Yu , Joel Hwang
Abstract: The present invention provides a method of preparing an isolated oligosaccharide or glycolipid by preparing the oligosaccharide or glycolipid having a hydrophobic group, such as a perfluorinated alkyl or a fatty acid, and separating the oligosaccharide or glycolipid using a solid-phase extraction cartridge.
-
公开(公告)号：US10160986B2
公开(公告)日：2018-12-25
申请号：US15017365
申请日：2016-02-05
Applicant: The Regents of the University of California
Inventor： Xi Chen , Hai Yu , Yanhong Li , Yi Chen , Jingyao Qu , Musleh M. Muthana , Kam Lau , Lars Bode
Abstract: The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.
-
公开(公告)号：US20160222048A1
公开(公告)日：2016-08-04
申请号：US14897596
申请日：2014-06-16
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Xi Chen , Hai Yu , Joel Hwang
CPC classification number: C07H15/04 , C07B2200/11 , C07H1/00 , C07H15/08 , C12P19/04 , C12P19/18 , C12P19/44
Abstract: The present invention provides a method of preparing an isolated oligosaccharide or glycolipid by preparing the oligosaccharide or glycolipid having a hydrophobic group, such as a perfluorinated alkyl or a fatty acid, and separating the oligosaccharide or glycolipid using a solid-phase extraction cartridge.
Abstract translation: 本发明提供通过制备具有疏水基团的寡糖或糖脂如全氟化烷基或脂肪酸制备分离的寡糖或糖脂的方法，并使用固相萃取柱分离寡糖或糖脂。
-
公开(公告)号：US11572548B2
公开(公告)日：2023-02-07
申请号：US16062883
申请日：2016-12-19
Applicant: The Regents of the University of California
Abstract: α1-2-fucosyltransferases, and methods and compositions for making and using α1-2-fucosyltransferases, are described herein.
-
Patent Agency Ranking
公开(公告)号：US09290530B2
公开(公告)日：2016-03-22
申请号：US14160451
申请日：2014-01-21
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC: C07H5/06 , C12P19/26 , C07H1/00 , C07H3/04 , C07H3/06 , C07H3/08 , C07H13/04 , C07H19/10 , C08B37/00 , C12P19/00 , C12P19/04 , C12P19/12 , C12P19/18
CPC classification number: C12P19/305 , C07H1/00 , C07H3/04 , C07H3/06 , C07H3/08 , C07H5/06 , C07H13/04 , C07H19/10 , C08B37/0075 , C12P19/00 , C12P19/04 , C12P19/12 , C12P19/18 , C12P19/26
Abstract: The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.
Abstract translation: 本发明提供了从单糖原料制备UDP-糖的一锅多酶方法。 本发明还提供了从单糖原料制备寡糖的一锅多酶方法。
-
公开(公告)号：US12162901B2
公开(公告)日：2024-12-10
申请号：US17491518
申请日：2021-09-30
Applicant: The Regents of the University of California
Inventor： Xi Chen , An Xiao , Anoopjit Kooner , Abhishek Santra , Ajit Varki , Hai Yu , Lee-Ping Wang , Wanqing Li
Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
-
公开(公告)号：US11441131B2
公开(公告)日：2022-09-13
申请号：US16906898
申请日：2020-06-19
Applicant: The Regents of the University of California
Inventor： Xi Chen , Lan Na , Hai Yu , John B. McArthur
Abstract: Heparosan synthase variants having improved expression levels, enhanced thermal stability, and/or reduced reverse glycosylation activity are provided. Methods for making oligosaccharides and polysaccharides, including heparin analogs and heparan sulfate analogs, are also described.
-
公开(公告)号：US09783838B2
公开(公告)日：2017-10-10
申请号：US14356376
申请日：2012-11-07
Applicant: The Regents of the University of California
Inventor： Xi Chen , Vireak Thon , Hai Yu
CPC classification number: C12P21/005 , C12N9/1051 , C12N9/1081 , C12P19/18 , C12P19/26 , C12P19/44
Abstract: The present invention provides novel methods for preparing glycosylated molecules such as oligosaccharides, glycolipids, and glycoproteins/peptides. Novel sialyltransferases are also disclosed. The method includes forming a reaction mixture containing an acceptor molecule, a donor substrate having a sugar moiety and a nucleotide, and a sialyltransferase selected from PmST3 (SEQ ID NO:7) and certain variants thereof. The reaction mixture is formed under conditions sufficient to transfer the sugar moiety from the donor substrate to the acceptor molecule, thereby forming the glycosylated molecule. In some embodiments, the acceptor molecule is selected from a natural product, an oligosaccharide, a glycoprotein, and a glycolipid. In some embodiments, the donor substrate is formed via conversion of a suitable hexosamine derivative to a cytidine 5′-monophosphate(CMP)-sialic acid in a one-pot reaction mixture containing asialic acid aldolase and a CMP-sialic acid synthetase.
-
公开(公告)号：US20170204444A9
公开(公告)日：2017-07-20
申请号：US15017365
申请日：2016-02-05
Applicant: The Regents of the University of California
Inventor： Xi Chen , Hai Yu , Yanhong Li , Yi Chen , Jingyao Qu , Musleh M. Muthana , Kam Lau , Lars Bode
CPC classification number: C12P19/305 , C07H1/00 , C07H3/04 , C07H3/06 , C07H3/08 , C07H5/06 , C07H13/04 , C07H19/10 , C08B37/0075 , C12P19/00 , C12P19/04 , C12P19/12 , C12P19/18 , C12P19/26
Abstract: The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.
-
-
-
-
-
-
-
-
-
Search Results
13
records
(took 0.026 seconds)
