公开(公告)号：US11161868B2

公开(公告)日：2021-11-02

申请号：US16418758

申请日：2019-05-21

Applicant: The Regents of the University of California

Inventor： Xi Chen ,  An Xiao ,  Anoopjit Kooner ,  Abhishek Santra ,  Ajit Varki ,  Hai Yu ,  Lee-Ping Wang ,  Wanqing Li

IPC: C07H15/04 ,  C07H15/12 ,  C07H15/14 ,  C07H15/203 ,  C12P19/28 ,  C12P19/44 ,  C12P19/64

Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.

公开(公告)号：US12162901B2

公开(公告)日：2024-12-10

申请号：US17491518

申请日：2021-09-30

Applicant: The Regents of the University of California

Inventor： Xi Chen ,  An Xiao ,  Anoopjit Kooner ,  Abhishek Santra ,  Ajit Varki ,  Hai Yu ,  Lee-Ping Wang ,  Wanqing Li

IPC: C07H15/04 ,  C07H15/12 ,  C07H15/14 ,  C07H15/203 ,  C12P19/28 ,  C12P19/44 ,  C12P19/64

Abstract: The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.

公开(公告)号：US11325936B2

公开(公告)日：2022-05-10

申请号：US16608640

申请日：2018-04-27

Applicant: The Regents of the University of California

Inventor： Xi Chen ,  An Xiao ,  Wanqing Li ,  Xixuan Li ,  Yanhong Li ,  Teri Slack

IPC: C07H5/04 ,  C12P19/28 ,  C07H1/00 ,  C07H15/207 ,  C12P19/26 ,  A61K31/7012

Abstract: New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.