公开(公告)号：US12030891B2

公开(公告)日：2024-07-09

申请号：US17297347

申请日：2019-11-18

Applicant: CIIMAR—CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL ,  UNIVERSIDADE DO PORTO ,  FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA

Inventor： Marta Ramos Pinto Correia Da Silva Carvalho Guerra ,  Madalena Maria De Magalhaes Pinto ,  Vitor Manuel De Oliveira E Vasconcelos ,  Joana Reis De Almeida ,  Elisabete Ribeiro Silva Geraldes ,  Maria Emilia Da Silva Pereira De Sousa

IPC: C07D493/04 ,  A01N43/90 ,  C07D519/00 ,  C09D5/16

CPC classification number: C07D493/04 ,  A01N43/90 ,  C07D519/00 ,  C09D5/1625

Abstract: Synthetic small molecules from an important class of heterocyclic derivatives and homologs and their use as antifouling agents for protection against marine biofouling. The antifouling compounds disclosed herein are environmentally friendly and are able to reduce marine biofouling without inducing toxic effects to target and non-target species. The claimed antifouling compounds also possess ability to be incorporated as antifouling additives in polymeric formulations. Thus, allowing its further application for the preparation of antifouling polymeric matrices, such as coatings, with no hazard effects for the environment.

公开(公告)号：US20230357301A1

公开(公告)日：2023-11-09

申请号：US18332157

申请日：2023-06-09

Applicant: Faculdade de Ciencias da Universidade de Lisboa ,  Instituto de Tecnologia Quimica e Biologica Antonio Xavier

Inventor： Christopher David Maycock ,  Maria Rita Mendes Bordalo Ventura Centeno Lima ,  Eva Correia Lourenco ,  Maria Helena Dias dos Santos ,  Ana Sofia da Cunha Miguel

IPC: C07H9/06 ,  C07H15/04

CPC classification number: C07H15/04 ,  C07H9/06

Abstract: A compound of formula I:





or a salt thereof, wherein:

R1 is —OC (H) (X) (CH2)nC(═O)OH;
R2 is —OH, —N3, or —N(H)C(═O)CH3; or
R1 and R2 together with the carbon atoms to which they are attached form





R3 is —H, —CH3, —CH2C(═O)OH, or —CH2OH;
X is —H, —CH3, —CH2OH, or CH2C(═O)OH; and n is 0 or 1.

公开(公告)号：US20210395264A1

公开(公告)日：2021-12-23

申请号：US17297347

申请日：2019-11-18

Applicant: CIIMAR - CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL ,  UNIVERSIDADE DO PORTO ,  FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA

Inventor： Marta RAMOS PINTO CORREIA DA SILVA CARVALHO GUERRA ,  Madalena Maria DE MAGALHAES PINTO ,  Vitor Manuel DE OLIVEIRA E VASCONCELOS ,  Joana REIS DE ALMEIDA ,  Elisabete RIBEIRO SILVA GERALDES ,  Maria Emilia DA SILVA PEREIRA DE SOUSA

IPC: C07D493/04 ,  C07D519/00 ,  A01N43/90 ,  C09D5/16

Abstract: Synthetic small molecules from an important class of heterocyclic derivatives and homologs and their use as antifouling agents for protection against marine biofouling. The antifouling compounds disclosed herein are environmentally friendly and are able to reduce marine biofouling without inducing toxic effects to target and non-target species. The claimed antifouling compounds also possess ability to be incorporated as antifouling additives in polymeric formulations. Thus, allowing its further application for the preparation of antifouling polymeric matrices, such as coatings, with no hazard effects for the environment.

公开(公告)号：US09775856B2

公开(公告)日：2017-10-03

申请号：US14384145

申请日：2013-03-11

Applicant: FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA

Inventor： Amélia Pilar Grases Santos Silva Rauter ,  Ana Rita Xavier De Jesus ,  Alice Isabel Mendes Martins ,  Catarina Alexandra Dos Santos Dias ,  Rogério José Tavares Ribeiro ,  Maria Paula Borges De Lemos Macedo ,  Jorge Alberto Guerra Justino ,  Helder Dias Mota Filipe ,  Rui Manuel Amaro Pinto ,  Bruno Miguel Nogueira Sepodes ,  Margarida Alexandra Patrício Goulart De Medeiros ,  Jesus Jimenéz Barbero ,  Cristina Airoldi ,  Francesco Nicotra

IPC: A61K31/7048 ,  A61K36/48

CPC classification number: A61K31/7048 ,  A61K36/48

Abstract: The present invention concerns the antidiabetic-activity of compounds type A, namely of 8-β-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to β-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic, agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes.The inhibitory activity of α-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphatase by these two extracts and the diethyl ether plant extract is also part of the present invention.