公开(公告)号：US08940778B2

公开(公告)日：2015-01-27

申请号：US13886448

申请日：2013-05-03

Applicant: AbbVie Inc.

Inventor： Yujia Dai ,  Steven K Davidsen ,  Anna M. Ericsson ,  Kresna Hartandi ,  Zhiqin Ji ,  Michael R. Michaelides

IPC: C07D291/00 ,  C07D409/10 ,  C07D409/04 ,  C07D401/12 ,  C07D261/20 ,  C07D409/12 ,  C07D403/12 ,  C07D409/14 ,  C07D275/04 ,  C07D401/04 ,  C07D401/10 ,  C07D413/12 ,  C07D403/14 ,  C07D231/56

CPC classification number: C07D231/56 ,  C07D261/20 ,  C07D275/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：US08362239B2

公开(公告)日：2013-01-29

申请号：US13479432

申请日：2012-05-24

Applicant: Matthew Laskoski ,  Teddy M Keller

Inventor： Matthew Laskoski ,  Teddy M Keller

IPC: C07D291/00 ,  C08G65/40 ,  C08G79/02

CPC classification number: H01F1/0063 ,  B82Y25/00 ,  C07D213/69 ,  C07D215/22 ,  C07D239/52 ,  C07D409/14 ,  C08G65/40 ,  C08G65/4006 ,  C08G65/48

Abstract: Disclosed are an oligomer and a phthalonitrile monomer having the formulas: M is a metal or H. The value n is an integer greater than or equal to 1 for the oligomer and greater than or equal to 0 for the phthalonitrile monomer. Ar1 and Ar2 are independently selected aromatic- or heterocyclic-containing groups. Ar1, Ar2, or both are heteroaromatic or heterocyclic groups containing a nitrogen, sulfur, or oxygen heteroatom. Also disclosed are thermosets and pyrolyzed materials made from the phthalonitrile monomer.

Abstract translation: 公开了具有下式的低聚物和邻苯二腈单体：M是金属或H.对于低聚物，值n为大于或等于1的整数，对于邻苯二甲腈单体，值大于或等于0。 Ar 1和Ar 2独立地选自芳族或含杂环基团。 Ar 1，Ar 2或两者都是含有氮，硫或氧杂原子的杂芳族或杂环基。 还公开了由邻苯二甲腈单体制备的热固性材料和热解材料。

公开(公告)号：US08088927B2

公开(公告)日：2012-01-03

申请号：US12223105

申请日：2006-11-15

Applicant: Darren Mansfield ,  Pierre-Yves Coqueron ,  Philippe Desbordes ,  Alain Villier ,  Marie-Claire Grosjean-Cournoyer ,  Stéphanie Gary ,  Stéphane Carbonne ,  Ralf Dunkel ,  Arounarith Tuch ,  Jean-Pierre Vors

Inventor： Darren Mansfield ,  Pierre-Yves Coqueron ,  Philippe Desbordes ,  Alain Villier ,  Marie-Claire Grosjean-Cournoyer ,  Stéphanie Gary ,  Stéphane Carbonne ,  Ralf Dunkel ,  Arounarith Tuch ,  Jean-Pierre Vors

IPC: C07D291/00 ,  C07D419/00 ,  C07D515/00 ,  C07D285/06

CPC classification number: C07D333/38 ,  C07D207/34 ,  C07D231/14 ,  C07D233/90 ,  C07D249/04 ,  C07D261/18 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D285/06 ,  C07D307/68

Abstract: The present invention relates to N-cycloalkyl-benzyl-amide derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions:

Abstract translation: 本发明涉及式（I）的N-环烷基 - 苄基 - 酰胺衍生物，其中取代基如说明书，其制备方法，它们作为杀真菌剂活性剂的用途，特别是以杀真菌剂组合物的形式，以及用于 使用这些化合物或组合物对植物病原真菌（特别是植物）的控制：

公开(公告)号：US07977476B2

公开(公告)日：2011-07-12

申请号：US12983853

申请日：2011-01-03

Applicant: Chanfeng Zhao ,  Igor Kozlov ,  Galina Steinberg-Tatman

Inventor： Chanfeng Zhao ,  Igor Kozlov ,  Galina Steinberg-Tatman

IPC: C07D293/10 ,  C07D291/00 ,  C07D279/00 ,  G01N33/543 ,  C07D487/12

CPC classification number: C07D251/12 ,  C07H21/00 ,  C07H21/04 ,  Y10T428/139

Abstract: Disclosed are methods of attaching biologically active compounds to a solid surface, comprising modifying the solid surface using triazine chloride and attaching the biologically active compound to the triazine moiety.

公开(公告)号：US07566800B2

公开(公告)日：2009-07-28

申请号：US10586481

申请日：2005-01-27

Applicant: Jens Scheidel ,  Christian Miller ,  Robert Baumann ,  Tim Jungkamp ,  Michael Bartsch ,  Gerd Haderlein ,  Hermann Luyken ,  Wolfgang Siegel ,  Peter Bassler

Inventor： Jens Scheidel ,  Christian Miller ,  Robert Baumann ,  Tim Jungkamp ,  Michael Bartsch ,  Gerd Haderlein ,  Hermann Luyken ,  Wolfgang Siegel ,  Peter Bassler

IPC: C07D291/00

CPC classification number: C07C253/30 ,  Y02P20/127 ,  C07C255/07

Abstract: The invention relates to a method for isomerization of pentene nitrile in an educt flow, wherein isomerization is performed on a homogeneously dissolved catalyst.

Abstract translation: 本发明涉及一种在流出物流中异戊烯腈的方法，其中异构化在均匀溶解的催化剂上进行。

公开(公告)号：US07420051B2

公开(公告)日：2008-09-02

申请号：US11249172

申请日：2005-10-11

Applicant: Andrés Francesch ,  Carolina Fernández ,  José Luis Chicharro ,  Pilar Gallego ,  Maria Zarzuelo ,  Ignacio Manzanares ,  Marta Perez ,  Carmen Cuevas ,  María Jes{dot over (u)}s Martin ,  Simon Munt

Inventor： Andrés Francesch ,  Carolina Fernández ,  José Luis Chicharro ,  Pilar Gallego ,  Maria Zarzuelo ,  Ignacio Manzanares ,  Marta Perez ,  Carmen Cuevas ,  María Jes{dot over (u)}s Martin ,  Simon Munt

IPC: C07D267/22 ,  C07D281/18 ,  C07D291/00 ,  C07D337/16 ,  C07D487/00

CPC classification number: C07D471/18 ,  C07D471/22 ,  C07D491/22 ,  C07D515/22

Abstract: Processes are provided for preparing compounds with a fused ring structure of formula (XIV). Such products include ecteinascidins and have a spiroamine-1,4-bridge. The process involving forming a 1,4 bridge using a 1-labile, 10-hydroxy, 18-protected hydroxyl, di-6,8-en-5-one fused ring compound. After formation of the 1,4 brige, C-18 protection is removed before spiroamine introduction.

Abstract translation: 提供了制备具有式（XIV）的稠环结构的化合物的方法。 这些产品包括海马神经氨酸，并具有螺胺-1,4-桥。 涉及使用1-不稳定的10-羟基，18-保护的羟基，二-6,8-烯-5-酮稠环化合物形成1,4桥的方法。 形成1,4格氏之后，在引入螺环胺之前，C-18保护被去除。

公开(公告)号：US07371853B2

公开(公告)日：2008-05-13

申请号：US10541476

申请日：2004-01-02

Applicant: Craig A. Coburn ,  Shawn J. Stachel ,  Joseph P. Vacca

Inventor： Craig A. Coburn ,  Shawn J. Stachel ,  Joseph P. Vacca

IPC: C07D267/22 ,  C07D281/18 ,  C07D291/00 ,  C07D337/16 ,  C07D487/00 ,  C07D498/00 ,  C07D513/00

CPC classification number: C07D273/02

Abstract: The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme in involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.

Abstract translation: 本发明涉及作为β-分泌酶的抑制剂并可用于治疗或预防所涉及的β-分泌酶如阿尔茨海默病的疾病的式（I）化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及β-分泌酶的疾病中的用途。

公开(公告)号：US07105660B2

公开(公告)日：2006-09-12

申请号：US10790810

申请日：2004-03-03

Applicant: Chi-Ming Che ,  Jiang-Lin Liang

Inventor： Chi-Ming Che ,  Jiang-Lin Liang

IPC: C07D291/00 ,  C07D419/00 ,  C07D515/00

CPC classification number: B01J31/183 ,  B01J31/0222 ,  B01J31/0247 ,  B01J31/0271 ,  B01J31/1835 ,  B01J31/20 ,  B01J2231/46 ,  B01J2531/025 ,  B01J2531/16 ,  B01J2531/72 ,  B01J2531/821 ,  B01J2531/825 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2540/225 ,  C07B2200/07 ,  C07D487/22

Abstract: An intramolecular amidation processes for substrates such as sulfamates using chiral and non-chiral metalloporphyrin complexes which can maximize catalytic activity, enhance efficiency, stereoselectivity and speed of amidation reactions is described. The chiral metalloporphyrin catalyzed amidation of sulfamates exhibits excellent cis-selectivity, affording cyclic sulfamidates with high enantiomeric excess values.

Abstract translation: 描述了使用可以使催化活性最大化，提高效率，立体选择性和酰胺化反应速度的手性和非手性金属卟啉配合物的底物如氨基磺酸盐的分子内酰胺化方法。 手性金属卟啉催化的氨基磺酸盐酰胺化显示优异的顺式选择性，提供具有高对映体过量值的环状磺酰胺酸盐。

公开(公告)号：US20040019204A1

公开(公告)日：2004-01-29

申请号：US10202581

申请日：2002-07-23

Inventor： Chi-Ming Che ,  Jiang-Lin Liang

IPC: C07D275/02 ,  C07D487/22 ,  C07D291/00

CPC classification number: B01J31/183 ,  B01J31/0222 ,  B01J31/0247 ,  B01J31/0271 ,  B01J31/1835 ,  B01J31/20 ,  B01J2231/46 ,  B01J2531/025 ,  B01J2531/16 ,  B01J2531/72 ,  B01J2531/821 ,  B01J2531/825 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2540/225 ,  C07B2200/07 ,  C07D487/22

Abstract: The present invention relates to novel intramolecular amidation processes for substrates such as sulfamate esters using chiral and non-chiral metalloporphyrin complexes, which can maximize catalytic activity and enhance efficiency, stereoselectivity and speed of amidation of these substrates. The intramolecular amidation of sulfamate ester exhibits excellent cis-selectivity, affording cyclic sulfamidates with high ee values catalyzed by chiral metalloporphyrin.

Abstract translation: 本发明涉及使用手性和非手性金属卟啉配合物的底物例如氨基磺酸酯的新型分子内酰胺化方法，其可以最大化催化活性并提高这些底物的效率，立体选择性和酰胺化速度。 氨基磺酸酯的分子内酰胺化表现出优异的顺式选择性，得到具有由手性金属卟啉催化的高ee值的环状磺酰胺酸酯。

公开(公告)号：US09187522B2

公开(公告)日：2015-11-17

申请号：US14296907

申请日：2014-06-05

Applicant: Receptos, Inc.

Inventor： Marcus F. Boehm ,  Esther Martinborough ,  Manisha Moorjani ,  Junko Tamiya ,  Liming Huang ,  Adam R. Yeager ,  Enugurthi Brahmachary ,  Thomas Fowler ,  Andrew Novak ,  Premji Meghani ,  Michael Knaggs

IPC: A61K31/33 ,  C07K5/072 ,  C07D233/54 ,  C07D233/60 ,  C07D401/04 ,  C07D403/04 ,  C07D239/26 ,  C07D239/34 ,  C07D409/12 ,  C07D413/04 ,  C07D241/08 ,  C07D417/12 ,  C07D255/02 ,  C07D263/32 ,  C07D271/06 ,  C07D271/107 ,  C07D495/04 ,  C07D277/24 ,  C07D285/12 ,  C07D211/22 ,  A61K31/4245 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/506 ,  A61K31/551 ,  A61K38/26 ,  C07D243/08 ,  C07D403/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  A61K45/06 ,  C07D291/00 ,  A61K31/426 ,  A61K31/433 ,  A61K31/4439 ,  A61K38/05 ,  C07D277/30 ,  C07D285/08

CPC classification number: C07K5/06113 ,  A61K31/33 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/506 ,  A61K31/551 ,  A61K38/05 ,  A61K38/26 ,  A61K45/06 ,  C07D211/22 ,  C07D233/54 ,  C07D233/60 ,  C07D239/26 ,  C07D239/34 ,  C07D241/08 ,  C07D243/08 ,  C07D255/02 ,  C07D263/32 ,  C07D271/06 ,  C07D271/107 ,  C07D277/24 ,  C07D277/30 ,  C07D285/08 ,  C07D285/12 ,  C07D291/00 ,  C07D401/04 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D495/04

Abstract: The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “” represents either or both the R and S form of the compound): where A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p and q are as defined herein.

Abstract translation: 本发明涉及调节胰高血糖素样肽1（GLP-1）受体的化合物，其合成方法及其治疗和/或预防用途的方法。 这些化合物独立地用作GLP-1受体的调节剂或增强剂，或者作为受体配体包括GLP-1肽GLP-1（7-36）和GLP-1（9-36）或与基于肽的疗法 ，其中A，B，C，Y 1，Y 2，Z，R 1，R 2，R 3，R 3，R 3，R 3， R4，R5，W1，n，p和q如本文所定义。