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    METHODS FOR DETECTION OF HYDROPHOBIC DRUGS
    8.
    发明申请
    METHODS FOR DETECTION OF HYDROPHOBIC DRUGS 有权
    检测疏水性药物的方法

    公开(公告)号：US20090155929A1

    公开(公告)日：2009-06-18

    申请号：US11956603

    申请日：2007-12-14

    申请人： Tie Q. Wei ,  Alan Craig ,  Amy Posey

    发明人： Tie Q. Wei ,  Alan Craig ,  Amy Posey

    IPC分类号： G01N33/566 ,  C07C31/18 ,  C07C317/02 ,  C07C223/02

    CPC分类号： G01N33/9493 ,  Y10S435/962 ,  Y10S436/815 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375 ,  Y10T436/25625

    摘要： Methods and reagents are disclosed for pretreating a sample suspected of containing a hydrophobic drug for conducting an assay method for detecting the hydrophobic drug. A combination is provided in a medium. The combination comprises (i) the sample, (ii) a releasing agent for releasing the hydrophobic drug and the metabolites from endogenous binding moieties, and (iii) a selective solubility agent that provides for substantially equal solubility of the hydrophobic drug and the metabolites in the medium. The selective solubility agent comprises a water miscible, non-volatile organic solvent and is present in the medium in a concentration sufficient to provide for substantially equal solubility of the hydrophobic drug and the metabolites in the medium. The medium, which may further comprise a hemolytic agent, is incubated under conditions for releasing the hydrophobic drug and the metabolites from endogenous binding moieties. For conducting an assay for the hydrophobic drug, the above pretreatment is performed and to the medium is added reagents for determining the presence and/or amount of the hydrophobic drug in the sample wherein the reagents comprise at least one antibody for the hydrophobic drug. The medium is examined for the presence of a complex comprising the hydrophobic drug and the antibody for the hydrophobic drug, the presence and/or amount of the complex indicating the presence and/or amount of the hydrophobic drug in the sample.

    摘要翻译： 公开了用于预处理疑似含有疏水性药物的样品以进行用于检测疏水性药物的测定方法的方法和试剂。 在介质中提供组合。 组合包括（i）样品，（ii）用于释放疏水性药物的释放剂和来自内源结合部分的代谢物，和（iii）选择性溶解剂，其提供疏水性药物和代谢物在 介质。 选择性溶解剂包括水混溶性，非挥发性有机溶剂，并且以足以提供疏水性药物和介质中代谢物基本上相等的溶解度的浓度存在于培养基中。 可以进一步包含溶血剂的培养基在用于从内源结合部分释放疏水性药物和代谢物的条件下孵育。 为了进行疏水性药物的测定，进行上述预处理，向培养基中加入用于测定样品中的疏水性药物的存在和/或量的试剂，其中试剂包含至少一种用于疏水性药物的抗体。 检查介质是否存在包含疏水性药物和疏水性药物抗体的复合物，表明该样品中疏水性药物的存在和/或量的存在和/或数量。

    Phenolic compounds and recording materials containing the same
    10.
    发明授权
    Phenolic compounds and recording materials containing the same 有权
    酚类化合物和含有相同的记录材料

    公开(公告)号：US07012159B1

    公开(公告)日：2006-03-14

    申请号：US10089131

    申请日：2000-10-04

    申请人： Tomoya Hidaka ,  Shinichi Sato ,  Tadashi Kawakami

    发明人： Tomoya Hidaka ,  Shinichi Sato ,  Tadashi Kawakami

    IPC分类号： C07C233/05 ,  C07C321/12 ,  C07C317/02

    CPC分类号： B41M5/3336 ,  B41M5/155 ,  C07C317/24 ,  C07C317/44 ,  C07C323/22 ,  C07C323/60

    摘要： Phenolic compounds of general formula (I); and recording materials characterized by containing one of them and exhibiting high light stability wherein R1 and R2 are each hydrogen or C1-C6 alkyl; m is an integer of 1 to 6; n is an integer of 0 to 2; p and t are each an integer of 0 to 3 with the proviso that not both are simultaneously 0; R3 and R4 are each nitro, carboxyl, halogeno, C1-C6 alkyl, or the like; q and u are each an integer of 0 to 2 with the proviso that when q or u is 2, R3s or R4s may be different from each other; and Y is CO or NR5CO (wherein R5 is hydrogen or the like), with the proviso that when Y is CO, p is 1 and that when p is 0 and Y is NR5CO, n is not 0.

    摘要翻译： 通式（I）的酚类化合物; 以及其中含有其中一种并表现出高光稳定性的记录材料，其中R 1和R 2各自为氢或C 1 -C 3烷基， 烷基; m为1〜6的整数。 n为0〜2的整数， p和t各自为0至3的整数，条件是两者不同时为0; R 3和R 4各自为硝基，羧基，卤代C 1 -C 6烷基，或者 喜欢; q和u各自为0至2的整数，条件是当q或u为2时，R 3或R 4可以彼此不同; 并且Y是CO或NR 5 CO（其中R 5是氢等），条件是当Y是CO时，p是1，当p是 0和Y是NR 5 CO，n不为0。