Compositions and methods for modification of biomolecules
    3.
    发明授权
    Compositions and methods for modification of biomolecules 有权
    用于修饰生物分子的组合物和方法

    公开(公告)号:US08703936B2

    公开(公告)日:2014-04-22

    申请号:US13962636

    申请日:2013-08-08

    IPC分类号: C07D225/04

    摘要: Provided are modified cycloalkyne compounds; and methods of use of such compounds in modifying biomolecules. Embodiments include a cycloaddition reaction that can be carried out under physiological conditions. The cycloaddition reaction involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo and in vitro.

    摘要翻译: 提供改性环炔化合物; 以及这些化合物在修饰生物分子中的使用方法。 实施方案包括可以在生理条件下进行的环加成反应。 环加成反应包括使修饰的环炔与靶生物分子上的叠氮化物部分反应,产生共价修饰的生物分子。 反应的选择性及其与水性环境的相容性使其在体内和体外应用。

    High performance luminescent compounds
    4.
    发明授权
    High performance luminescent compounds 有权
    高效发光化合物

    公开(公告)号:US08273875B2

    公开(公告)日:2012-09-25

    申请号:US12619536

    申请日:2009-11-16

    IPC分类号: C07D245/04 C07D225/04

    摘要: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.

    摘要翻译: 实施方案涉及化学和生物化学领域,更具体地涉及光稳定并且耐淬火的新型近红外染料。 这些染料属于一种新型的方酸酯轮烷系列,它们特别适用于生物应用。 还公开了合成染料的方法和使用染料的方法。