-
1.发明授权公开(公告)号：US07648976B2
公开(公告)日：2010-01-19
申请号：US11595005
申请日：2006-11-08
申请人： Peter J. Licari , Timothy Leaf , Ruchir P. Desai , Jorge L. Galazzo , Greg O. Buchanan , Stephen William Watt , Alexander Redvers Eberlin , Robert Arslanian
发明人： Peter J. Licari , Timothy Leaf , Ruchir P. Desai , Jorge L. Galazzo , Greg O. Buchanan , Stephen William Watt , Alexander Redvers Eberlin , Robert Arslanian
IPC分类号： C07D225/04 , C07D225/06 , A61K9/00
CPC分类号： C07D225/04
摘要： Polymorphs and pharmaceutical formulations of 17-allylamino-17-demethoxygeldanamycin (17-AAG).
摘要翻译： 17-烯丙基氨基-17-去甲氧基格尔德霉素（17-AAG）的多晶型物和药物制剂。
-
公开(公告)号：US20090042847A1
公开(公告)日：2009-02-12
申请号：US12129369
申请日：2008-05-29
申请人： Peter J. Licari , Timothy Leaf , Ruchir P. Desai , Jorge L. Galazzo , Greg O. Buchanan , Stephen William Watt , Alexander Redvers Eberlin , Robert Arslanian
发明人： Peter J. Licari , Timothy Leaf , Ruchir P. Desai , Jorge L. Galazzo , Greg O. Buchanan , Stephen William Watt , Alexander Redvers Eberlin , Robert Arslanian
IPC分类号： A61K31/395 , C07D225/06
CPC分类号： C07D225/04 , C07D225/06
摘要： Polymorphs and pharmaceutical formulations of 17-allylamino-17-demethoxy-geldanamycin (17-AAG).
摘要翻译： 17-烯丙基氨基-17-去甲氧基 - 格尔德霉素（17-AAG）的多晶型物和药物制剂。
-
公开(公告)号：US20130211135A1
公开(公告)日：2013-08-15
申请号：US13878146
申请日：2011-10-05
申请人： Keith H. Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
发明人： Keith H. Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
IPC分类号： C07C227/18 , C07C51/41
CPC分类号： C07C227/18 , A61K31/192 , A61K31/198 , C07C51/412 , C07C229/26 , C07C57/32
摘要： Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, inter-mixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms.
摘要翻译： 本文公开了制备L-鸟氨酸苯乙酸酯的方法。 该方法可以包括例如将L-鸟氨酸的卤化物盐与乙酸苯酯相互混合。 该方法还可以包括原位形成乙酸苯酯盐。 本申请还涉及从这些方法获得的各种组合物，包括结晶形式。
-
公开(公告)号：US20120208885A1
公开(公告)日：2012-08-16
申请号：US13436642
申请日：2012-03-30
申请人： Keith Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
发明人： Keith Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
IPC分类号： A61K31/195 , A61P1/02 , A61P1/16 , C07C229/26
CPC分类号： C07C227/40 , A61K31/192 , A61K31/198 , A61K31/205 , C07C51/42 , C07C57/32 , C07C227/42 , C07C229/26
摘要： Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
摘要翻译： 本文公开的是L-鸟氨酸苯乙酸酯的形式及其制备方法。 在一些实施方案中，结晶形式可以是I，II，III和V型，或其混合物。 结晶形式可以配制用于治疗具有肝病的受试者，例如肝性脑病。 因此，一些实施方案包括施用L-鸟氨酸苯基乙酸酯的制剂和方法。
-
公开(公告)号：US08173706B2
公开(公告)日：2012-05-08
申请号：US12753763
申请日：2010-04-02
申请人： Keith Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
发明人： Keith Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
IPC分类号： A61K31/185 , C07C53/134
CPC分类号： C07C227/40 , A61K31/192 , A61K31/198 , A61K31/205 , C07C51/42 , C07C57/32 , C07C227/42 , C07C229/26
摘要： Disclosed herein are crystalline forms of L-ornithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
摘要翻译： 本文公开了L-鸟氨酸苯乙酸酯的结晶形式及其制备方法。 在一些实施方案中，结晶形式可以是I，II，III和V型，或其混合物。 结晶形式可以配制用于治疗具有肝病的受试者，例如肝性脑病。 因此，一些实施方案包括施用L-鸟氨酸苯基乙酸酯的制剂和方法。
-
公开(公告)号：US20100280119A1
公开(公告)日：2010-11-04
申请号：US12753763
申请日：2010-04-02
申请人： Keith Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
发明人： Keith Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
IPC分类号： A61K31/198 , C07C229/26 , A61P25/00 , A61P1/16
CPC分类号： C07C227/40 , A61K31/192 , A61K31/198 , A61K31/205 , C07C51/42 , C07C57/32 , C07C227/42 , C07C229/26
摘要： Disclosed herein are crystalline forms of L-ornithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
摘要翻译： 本文公开了L-鸟氨酸苯乙酸酯的结晶形式及其制备方法。 在一些实施方案中，结晶形式可以是I，II，III和V型，或其混合物。 结晶形式可以配制用于治疗具有肝病的受试者，例如肝性脑病。 因此，一些实施方案包括施用L-鸟氨酸苯基乙酸酯的制剂和方法。
-
公开(公告)号：US08946473B2
公开(公告)日：2015-02-03
申请号：US13878146
申请日：2011-10-05
申请人： Keith H. Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
发明人： Keith H. Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
IPC分类号： C07C227/18 , C07C229/26 , A61K31/192 , A61K31/198 , C07C51/41
CPC分类号： C07C227/18 , A61K31/192 , A61K31/198 , C07C51/412 , C07C229/26 , C07C57/32
摘要： Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, inter-mixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms.
摘要翻译： 本文公开了制备L-鸟氨酸苯乙酸酯的方法。 该方法可以包括例如将L-鸟氨酸的卤化物盐与乙酸苯酯相互混合。 该方法还可以包括原位形成乙酸苯酯盐。 本申请还涉及从这些方法获得的各种组合物，包括结晶形式。
-
公开(公告)号：US08492439B2
公开(公告)日：2013-07-23
申请号：US13436642
申请日：2012-03-30
申请人： Keith Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
发明人： Keith Anderson , Jim Behling , Christine Henderson Dougan , Stephen William Watt , Peter Manini , Attilia Figini
IPC分类号： C07C57/32 , A61K31/205 , C07C227/42 , C07C229/26
CPC分类号： C07C227/40 , A61K31/192 , A61K31/198 , A61K31/205 , C07C51/42 , C07C57/32 , C07C227/42 , C07C229/26
摘要： Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.037 秒)
