公开(公告)号：US20170320808A1

公开(公告)日：2017-11-09

申请号：US15526780

申请日：2014-11-17

Applicant: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES

Inventor： Youming NI ,  Wenliang ZHU ,  Yong LIU ,  Hongchao LIU ,  Zhongmin LIU ,  Lina LI ,  Shiping LIU ,  Hui ZHOU

IPC: C07C69/06 ,  B01J29/70 ,  C07C67/39 ,  B01J29/40 ,  B01D3/14 ,  C07C43/10 ,  C07C43/04 ,  C07C53/02 ,  C08F212/08 ,  C08F212/36

CPC classification number: C07C69/06 ,  B01D3/14 ,  B01J29/40 ,  B01J29/7038 ,  C07C41/56 ,  C07C43/043 ,  C07C43/10 ,  C07C53/02 ,  C07C67/39 ,  C08F212/08 ,  C08F212/36 ,  C07C43/30

Abstract: A method for preparing methyl formate in which a raw material containing formaldehyde, methanol and/or dimethyl ether is introduced into a first reaction zone to come into contact with a catalyst A, and a component I is obtained by separation, the component I is introduced into a second reaction zone to come into contact with a catalyst B so as to obtain, by separation, methyl formate as a product, dimethyl ether that is returned to the first reaction zone and a component II that is returned to the second reaction zone, the catalysts have a long service life, the reaction conditions are mild, and the utilization rate of the raw material is high, thus enabling a continuous production for large-scale industrial application.

公开(公告)号：US06921833B1

公开(公告)日：2005-07-26

申请号：US10031166

申请日：2000-07-26

Applicant: Heinz Auer ,  Jürgen Dahlhaus ,  Karl Fischer ,  Hans Hammer ,  Jochen Kellenbenz ,  Michael Schulz ,  Joachim Thiel ,  Maximilian Vicari

Inventor： Heinz Auer ,  Jürgen Dahlhaus ,  Karl Fischer ,  Hans Hammer ,  Jochen Kellenbenz ,  Michael Schulz ,  Joachim Thiel ,  Maximilian Vicari

IPC: B01D3/00 ,  B01J3/00 ,  B01J3/02 ,  B01J19/00 ,  C07B61/00 ,  C07C29/80 ,  C07C31/04 ,  C07C67/36 ,  C07C69/06

CPC classification number: C07C67/36 ,  C07C69/06

Abstract: A description is given of a process for preparing methyl formate by reacting excess methanol with carbon monoxide under superatmospheric pressure and at elevated temperature in the presence of alkali metal methoxide or alkaline earth metal methoxide as catalyst in a pressure-rated reactor, in which the use of at least two reactor elements, preferably operated in countercurrent, at about 100° C. and a pressure of about 100 bar in combination with a solids-free desalting of the reaction product makes possible very economical, largely trouble-free production of methyl formate in any desired quality and with a very good production capacity.Furthermore, the process for solids-free desalting and apparatuses for carrying out this process are described.

Abstract translation: 给出了在过压甲醇钠或碱土金属甲醇盐作为催化剂存在下，在超压大气压和高温下使过量甲醇与一氧化碳反应制备甲酸甲酯的方法，其中使用 的至少两个反应器元件，优选逆流操作，约100℃，约100巴的压力与无固体脱盐反应产物的组合使得非常经济，大大无故障地生产甲酸甲酯 以任何期望的质量和非常好的生产能力。 此外，描述了无固体脱盐的方法和用于实施该方法的装置。

公开(公告)号：US6100271A

公开(公告)日：2000-08-08

申请号：US483871

申请日：1995-06-07

Applicant: J. Peter Klein ,  Alistair J. Leigh ,  Gail E. Underiner ,  Anil M. Kumar

Inventor： J. Peter Klein ,  Alistair J. Leigh ,  Gail E. Underiner ,  Anil M. Kumar

IPC: C07D239/54 ,  A61K31/42 ,  A61K31/421 ,  A61K31/496 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P9/10 ,  A61P9/14 ,  A61P11/16 ,  A61P13/02 ,  A61P15/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/04 ,  A61P37/08 ,  A61P43/00 ,  C07C47/198 ,  C07C47/277 ,  C07C49/175 ,  C07C49/255 ,  C07C57/46 ,  C07C59/64 ,  C07C65/21 ,  C07C69/06 ,  C07C69/14 ,  C07C69/24 ,  C07C69/608 ,  C07C69/612 ,  C07C225/06 ,  C07C233/01 ,  C07D239/56 ,  C07D241/18 ,  C07D263/30 ,  C07D473/04 ,  C07D473/06 ,  C07D473/10 ,  C07D487/04 ,  C07D513/04 ,  C07D521/00

CPC classification number: C07D487/04 ,  C07D473/04 ,  C07D473/06 ,  C07D473/10 ,  C07D513/04

Abstract: Therapeutic compounds with at least one carboxylic acid, ester or amide-substituted side chain have the formula:CORE MOIETY --(R).sub.jwherein j is an integer from one to three. The core moiety is non-cyclic or cyclic (carbocyclic or heterocyclic). R may be selected from among hydrogen, halogen, hydroxyl, amino, substituted or unsubstituted C.sub.(1-10) alkyl, C.sub.(2-10) alkenyl, carbocyclic or heterocyclic groups and at least one R has the formula I: ##STR1## wherein: one or two p are the integer one, otherwise p is two; and n is an integer from three to twenty; R.sub.1 is selected from the group consisting of substituted and unsubstituted CH.sub.2 ; NR.sub.3, R.sub.3 being hydrogen, substituted or unsubstituted C.sub.(1-20) alkyl, C.sub.(1-20) alkoxyl, C.sub.(2-20) alkenyl or C.sub.(1-20) hydroxyalkyl, or carbocyclic or heterocyclic group; O; --CHR.sub.4 O--, R.sub.4 being substituted or unsubstituted C.sub.(1-20) alkyl, C.sub.(1-20) alkoxyl, C.sub.(2-20) alkenyl, C.sub.(1-20) hydroxyalkyl, or R.sub.2 and R.sub.4 join to form a substituted or unsubstituted heterocycle having four to seven ring atoms, the ether group --O-- of --CHR.sub.4 O-- being a member of the heterocycle. R.sub.2 is selected from the group consisting of hydrogen; halogen; substituted or unsubstituted C.sub.(1-10) alkyl; C.sub.(1-10) alkoxyl; C.sub.(2-10) alkenyl; C.sub.(1-10) hydroxyallyl; --A(R.sub.5).sub.m, A being N or O, m being one or two and R.sub.5 being hydrogen, a substituted or unsubstituted C.sub.(1-10) alkyl, C.sub.(1-10) alkoxyl, C.sub.(2-10) alkenyl or C.sub.(1-10) hydroxyalkyl), or carbocyclic or heterocyclic group. At least one of R.sub.1 is NR.sub.3, O or --CHR.sub.4 O--, or R.sub.2 is --A(R.sub.5).sub.m. The compounds and pharmaceutical compositions thereof are useful as therapies for diseases advanced via intracellular signaling through specific intracellular signaling pathways by mediating a signaling response to an external stimuli.

Abstract translation: 具有至少一个羧酸，酯或酰胺取代的侧链的治疗化合物具有下式：CORE MOIETY - （R）j，其中j是1至3的整数。 核心部分是非环状或环状的（碳环或杂环）。 R可以选自氢，卤素，羟基，氨基，取代或未取代的C（1-10）烷基，C（2-10）烯基，碳环或杂环基，并且至少一个R具有式I：其中： 或两个p为整数，否则p为2; n为3〜20的整数。 R1选自取代和未取代的CH 2; NR 1，R 3为氢，取代或未取代的C 1-20烷基，C（1-20）烷氧基，C（2-20）烯基或C（1-20）羟基烷基或碳环或杂环基; O; -CHR4O-，R4是取代或未取代的C（1-20）烷基，C（1-20）烷氧基，C（2-20）烯基，C（1-20）羟基烷基或R2和R4连接形成取代的 或具有4-7个环原子的未取代的杂环，-CHR4O-的醚基-O-是杂环的成员。 R2选自氢; 卤素; 取代或未取代的C（1-10）烷基; C（1-10）烷氧基; C（2-10）烯基; C（1-10）羟基烯基; -A（R5）m，A是N或O，m是一个或两个，R5是氢，取代或未取代的C（1-10）烷基，C（1-10）烷氧基，C（2-10）烯基 或C（1-10）羟烷基）或碳环或杂环基。 R 1中的至少一个为NR 3，O或-CHR 4 O-，或R 2为-A（R 5）m。 这些化合物及其药物组合物可用作通过介导对外部刺激的信号反应的特异性细胞内信号通路的细胞内信号传导的疾病的治疗。

公开(公告)号：US6093857A

公开(公告)日：2000-07-25

申请号：US928524

申请日：1997-09-12

Applicant: Rolf Fischer ,  Rolf Pinkos ,  Norbert Rieber ,  Michael Schulz ,  Joaquim Henrique Teles

Inventor： Rolf Fischer ,  Rolf Pinkos ,  Norbert Rieber ,  Michael Schulz ,  Joaquim Henrique Teles

IPC: B01J27/128 ,  B01J27/138 ,  B01J31/02 ,  B01J31/12 ,  C07B61/00 ,  C07C67/04 ,  C07C69/06 ,  C07C35/06

CPC classification number: C07C67/04 ,  C07C29/1285 ,  C07C2101/08

Abstract: A process for preparing cyclopentyl formates of the formula (II) ##STR1## by reacting cyclopentenes of the formula (I) ##STR2## where R.sup.1, R.sup.2 and R.sup.3, independently of one another, are hydrogen atoms or C.sub.1-8 -alkyl,with formic acid in the presence of an acid catalyst.

Abstract translation: 通过使式（I）的环戊烯与其中R1，R2和R3彼此独立地为氢原子或C1-8烷基的环戊烯与甲酸在存在下反应制备式（II）的环戊基甲酸酯的方法， 酸催化剂。

公开(公告)号：US5562853A

公开(公告)日：1996-10-08

申请号：US314836

申请日：1994-09-29

Applicant: Barbara H. Minor ,  Allen C. Sievert

Inventor： Barbara H. Minor ,  Allen C. Sievert

IPC: A62D1/02 ,  A62D3/00 ,  C07C9/02 ,  C07C13/02 ,  C07C19/08 ,  C07C43/04 ,  C07C69/06 ,  C07C323/03 ,  C07D303/04 ,  C07D307/06 ,  C08J9/14 ,  C09K3/30 ,  C09K5/04 ,  C10M105/50 ,  C10N40/08 ,  C11D7/24 ,  C11D7/26 ,  C11D7/30 ,  C11D7/34 ,  C11D7/50 ,  C23G5/024 ,  C23G5/028

CPC classification number: C11D7/5077 ,  C08J9/149 ,  C09K3/30 ,  C09K5/045 ,  C11D7/5072 ,  C23G5/024 ,  C23G5/02803 ,  C08J2203/12 ,  C08J2203/142 ,  C08J2207/04 ,  C09K2205/104 ,  C09K2205/11 ,  C09K2205/114 ,  C09K2205/12 ,  C09K2205/134 ,  C09K2205/32

Abstract: Compositions include compositions of 1,1,2,2,3,3,4,4-octafluorobutane and a hydrocarbon having from 3 to 7 carbon atoms. Specific examples include 1,1,2,2,3,3,4,4-octafluorobutane and butane, cyclopropane, isobutane, propane, cyclopentane, 2,2-dimethylbutane, n-pentane, 2-methylbutane, cyclohexane, 2,3-dimethylpentane, 3-ethylpentane, heptane, hexane or methylcyclopentane. Also included in this invention are compositions of 1,1,2,2,3,3,4,4-octafluorobutane and ethyl formate, propylene oxide, bis(pentafluoroethyl)sulfide, dimethoxyethane or tetrahydrofuran. These compositions, which may be azeotropic or azeotrope-like, may be used as refrigerants, cleaning agents, expansion agents for polyolefins and polyurethanes, aerosol propellants, refrigerants, heat transfer media, gaseous dielectrics, fire extinguishing agents, power cycle working fluids, polymerization media, particulate removal fluids, carrier fluids, buffing abrasive agents or displacement drying agents.

Abstract translation: 组合物包括1,1,2,2,3,3,4,4-八氟丁烷的组合物和具有3至7个碳原子的烃。 具体实例包括1,1,2,2,3,3,4,4-八氟丁烷和丁烷，环丙烷，异丁烷，丙烷，环戊烷，2,2-二甲基丁烷，正戊烷，2-甲基丁烷，环己烷，2,3 二甲基戊烷，3-乙基戊烷，庚烷，己烷或甲基环戊烷。 本发明还包括1,1,2,2,3,3,4,4-八氟丁烷和甲酸乙酯，环氧丙烷，双（五氟乙基）硫醚，二甲氧基乙烷或四氢呋喃的组合物。 这些可以共沸或类共沸的组合物可用作制冷剂，清洁剂，聚烯烃和聚氨酯的膨胀剂，气溶胶推进剂，制冷剂，传热介质，气体电介质，灭火剂，动力循环工作流体，聚合 介质，微粒去除液，载液，抛光磨料或置换干燥剂。

公开(公告)号：US5206217A

公开(公告)日：1993-04-27

申请号：US811545

申请日：1991-12-20

Applicant: Walter C. Frank

Inventor： Walter C. Frank

IPC: A61K8/33 ,  A61Q13/00 ,  C07B61/00 ,  C07C2/70 ,  C07C13/465 ,  C07C45/43 ,  C07C45/51 ,  C07C47/546 ,  C07C67/00 ,  C07C69/06 ,  C07C69/07 ,  C07C251/48 ,  C07C255/52 ,  C11B9/00 ,  C11D3/50 ,  D06M13/02 ,  D06M13/07 ,  D06M13/12 ,  D06M23/00

CPC classification number: C11B9/0049 ,  C07C13/465 ,  C07C251/48 ,  C07C255/52 ,  C07C45/513 ,  C07C47/546 ,  C07C2102/08

Abstract: The present invention relates to novel indane compounds, such as, for example, 5-formyl-1,1,2,3,3,4,6-heptamethylindane, a compound of the formula ##STR1## and to compositions including the same, as well as to methods for their preparation. Compounds and compositions of the invention possess a fragrant musk-like aroma and have utility in the perfumery and/or other industries.

Abstract translation: 本发明涉及新的二氢化茚化合物，例如5-甲酰基-1,1,2,3,3,4,6-七甲基茚满，式“IMAGE”的化合物及其组合物， 以及其准备方法。 本发明的化合物和组合物具有香味的麝香样香气，并且在香料和/或其他工业中具有效用。

公开(公告)号：US4480122A

公开(公告)日：1984-10-30

申请号：US423977

申请日：1982-09-27

Applicant: Theodore Horlenko ,  Adolfo Aguilo

Inventor： Theodore Horlenko ,  Adolfo Aguilo

IPC: C07C67/39 ,  C07C67/40 ,  C07C69/06

CPC classification number: C07C67/39 ,  C07C67/40 ,  Y10S502/524

Abstract: A process for producing methyl formate is described by the dehydrogenation of methanol over a catalyst produced by reducing a precursor comprising copper oxide and a spinel structure support comprising the oxides of zinc and aluminum, said precursor containing 10 to 80 percent copper.

Abstract translation: 通过甲醇脱氢催化剂描述生产甲酸甲酯的方法，所述催化剂通过还原包含氧化铜的前体和包含锌和铝的氧化物的尖晶石结构载体制备，所述前体含有10至80％的铜。

公开(公告)号：US4216339A

公开(公告)日：1980-08-05

申请号：US776369

申请日：1977-03-10

Applicant: Willy Couteau ,  Jean Ramioulle

Inventor： Willy Couteau ,  Jean Ramioulle

IPC: C07C69/06 ,  B01J10/00 ,  B01J19/24 ,  B01J19/26 ,  B01J31/00 ,  C07B61/00 ,  C07C67/36

CPC classification number: B01J19/26 ,  B01J19/2465 ,  B01J2219/00103 ,  B01J2219/0011 ,  B01J2219/00164

Abstract: The invention relates to an improved process for the production of methyl formate, wherein a current of a gas containing carbon monoxide is reacted at elevated temperature (70.degree.-110.degree. C.) and pressure (20-110 bars) in a reaction zone with a recycled current of liquid reaction mixture containing(a) methanol(b) an alkali metal or alkaline earth metal methoxide as catalyst, and(c) methyl formate produced as reaction product,part of the current of liquid reaction mixture being withdrawn in order to recover methyl formate therefrom.The characteristic feature of the invention consists in that the recycled liquid reaction mixture is used for sucking and dispersing the current of gas in the reaction mixture. Advantages of the process are: excellent heat exchange, high productivity, absence of solid deposits on the internal surfaces of the apparatus, lower operating pressures and temperatures, use of apparatus of smaller dimensions, suppression of recycling of carbon monoxide, etc.

Abstract translation: 本发明涉及一种生产甲酸甲酯的改进方法，其中含有一氧化碳的气体的电流在升温（70-110℃）和压力（20-110巴）下在反应区中反应， 含有（a）甲醇（b）碱金属或碱土金属甲醇盐作为催化剂的液体反应混合物的回收电流，和（c）作为反应产物生产的甲酸甲酯，将部分液体反应混合物的电流抽出，以便 从其中回收甲酸甲酯。 本发明的特征在于回收的液体反应混合物用于吸收和分散反应混合物中的气体流。 该方法的优点是：优异的热交换，高生产率，设备内表面上没有固体沉积物，较低的操作压力和温度，使用较小尺寸的设备，抑制一氧化碳的再循环等。

公开(公告)号：US4147672A

公开(公告)日：1979-04-03

申请号：US708075

申请日：1976-07-23

Applicant: Karl-Heinrich Schulte-Elte ,  Bruno Willhalm ,  Fritz Gautschi

Inventor： Karl-Heinrich Schulte-Elte ,  Bruno Willhalm ,  Fritz Gautschi

IPC: C07C69/07 ,  A23K20/105 ,  A23L1/226 ,  A24B3/12 ,  A61K8/33 ,  A61K8/35 ,  A61K8/37 ,  A61Q13/00 ,  C07C29/32 ,  C07C29/40 ,  C07C45/00 ,  C07C45/29 ,  C07C45/40 ,  C07C45/51 ,  C07C45/62 ,  C07C45/68 ,  C07C45/71 ,  C07C45/74 ,  C07C47/42 ,  C07C49/303 ,  C07C49/543 ,  C07C49/553 ,  C07C49/557 ,  C07C49/603 ,  C07C49/647 ,  C07C67/00 ,  C07C69/06 ,  C07C401/00 ,  C07C403/00 ,  C07C403/10 ,  C07C403/12 ,  C07C403/16 ,  C07D303/32 ,  C07D317/12 ,  C07D317/34 ,  C07D319/06 ,  C07D321/00 ,  C11B9/00 ,  C07C49/43

CPC classification number: C11B9/0073 ,  A23K20/105 ,  C07C29/32 ,  C07C29/40 ,  C07C403/02 ,  C07C403/08 ,  C07C403/12 ,  C07C403/16 ,  C07C45/29 ,  C07C45/298 ,  C07C45/40 ,  C07C45/512 ,  C07C45/513 ,  C07C45/515 ,  C07C45/62 ,  C07C45/68 ,  C07C45/71 ,  C07C45/74 ,  C07C47/42 ,  C07C49/303 ,  C07C49/543 ,  C07C49/553 ,  C07C49/603 ,  C07D317/12 ,  C11B9/0034 ,  C11B9/0049 ,  C07C2101/14 ,  C07C2101/16

Abstract: New oxygenated alicyclic derivatives useful as perfuming and odor modifying agents in the manufacture of perfumes or perfumed products, and as flavoring and taste-modifying agents in the aromatization of foodstuffs in general and imitation flavors for foodstuffs, beverages, animal feeds, pharmaceutical preparations and tobacco products.Novel processes for the preparation of said alicyclic derivatives and compositions of matter relating to mixtures containing same.

Abstract translation: 用于制造香料或香料产品中作为加香和气味改性剂的新型含氧脂环族衍生物，以及一般食品芳构化中的调味剂和调味剂，以及用于食品，饮料，动物饲料，药物制剂和烟草的仿香料 产品。

公开(公告)号：US3978008A

公开(公告)日：1976-08-31

申请号：US499556

申请日：1974-08-22

Applicant: Karl-Heinrich Schulte-Elte ,  Michel Joyeux ,  Gunther Ohloff

Inventor： Karl-Heinrich Schulte-Elte ,  Michel Joyeux ,  Gunther Ohloff

IPC: C07C69/06 ,  A23K1/16 ,  A23L27/20 ,  A24B15/34 ,  A61K8/37 ,  A61K47/06 ,  A61Q13/00 ,  C11B9/00 ,  A61K7/46

CPC classification number: C11B9/0042 ,  A23L27/203 ,  A24B15/34

Abstract: New oxygenated sesquiterpenic derivatives useful as perfuming and odor-modifying agents in the manufacture of perfumes and perfumed articles, and as flavoring and taste-modifying agents in the aromatization of foodstuffs in general and imitation flavors for foodstuffs, animal feeds, beverages, pharmaceutical preparations and tobacco products.Novel process for the preparation of said compounds and compositions of matter relating to mixtures containing same.

Abstract translation: 用于制造香料和香料制品中的作为加香和气味改性剂的新型含氧倍半萜烯衍生物，以及一般食品芳构化中的调味剂和调味剂以及用于食品，动物饲料，饮料，药物制剂的模仿香料， 烟草制品。