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    Production of high-quality aromatic amino azo compounds by the rearrangement of 1,3-diaryl triazenes
    2.
    发明授权
    Production of high-quality aromatic amino azo compounds by the rearrangement of 1,3-diaryl triazenes 失效
    通过重排1,3-二芳基三唑生产高品质芳香族氨基偶氮化合物

    公开(公告)号：US4279815A

    公开(公告)日：1981-07-21

    申请号：US2010

    申请日：1979-01-09

    申请人： Frank E. Herkes

    发明人： Frank E. Herkes

    IPC分类号： C07C245/08 ,  C07C67/00 ,  C07C241/00 ,  C07C245/24 ,  C09B27/00 ,  C07C107/06 ,  C07C115/00

    CPC分类号： C07C245/24

    摘要： A 1,3-diaryl triazene, in a solution obtained by the diazotization-coupling of a primary aromatic monoamine with a gas containing NO and NO.sub.2, which solution contains the monoamine and up to about 30 percent by weight of the triazene, based on the weight of the solution, is contacted with 0.4-2.0 percent of a strong acid, preferably nitric acid (based on the weight of the triazene-containing solution), at 50.degree.-120.degree. C. The triazene rearranges to an aromatic amino azo compound in a high para/ortho isomer ratio with minimum formation of binuclear by-products.

    摘要翻译： 基于主芳族单胺与含有NO和NO 2的气体的重氮化偶合获得的1,3-二芳基三氮烯，该溶液含有单胺和至多约30重量％的三氮烯，基于 重量的溶液在50-120℃下与0.4-2.0％的强酸，优选硝酸（基于含三氮烯的溶液的重量）接触。三氮烯重新排列成芳族氨基偶氮化合物 具有较高的对位/邻位异构体比例，最小形成双核副产物。

    Alkyl triazeno uracil compounds and method of preparation thereof
    3.
    发明授权
    Alkyl triazeno uracil compounds and method of preparation thereof 失效
    烷基三氮烯尿嘧啶化合物及其制备方法

    公开(公告)号：US4092305A

    公开(公告)日：1978-05-30

    申请号：US623909

    申请日：1975-10-20

    申请人： Leroy B. Townsend ,  T. Craig Thurber

    发明人： Leroy B. Townsend ,  T. Craig Thurber

    IPC分类号： A01N43/54 ,  C07C115/00

    CPC分类号： A01N43/54

    摘要： 5-ALKYL TRIAZENO URACIL COMPOUNDS AND DERIVATIVES THEREOF WERE SYNTHESIZED BY REACTING AN ALKYL AMINE SUCH AS DIMETHYLAMINE WITH A METHONAL ADDUCT OF 5-DIAZOURACIL AND NUCLEOSIDES THEREOF, UNDER STRINGENT REACTION CONDITIONS TO YIELD THE DESIRED COMPOUNDS. These alkyl triazeno uracil compounds have the structure ##STR1## wherein R is hydrogen or a carbohydrate group, particularly a pentose or hexose monosaccaride such as ribose, arabinose, glucose, and the like, and R' and R" are lower alkyl groups having one to four carbon atoms and wherein R' and R" may be the same or different alkyl groups. The compounds of this invention have been found especially effective as antibacterial and antifungal agents and in inhibiting carcinoma growth in animal tissue.

    摘要翻译： 通过反应碱性胺如二甲基胺与5-二氮杂萘酮和其核苷酸的甲基添加剂合成5-氨基三苯基脲类化合物及其衍生物，根据对所希望的化合物的反应条件。 这些烷基三氮烯酸尿嘧啶化合物具有其中R是氢或碳水化合物基团，特别是戊糖或己糖单糖如核糖，阿拉伯糖，葡萄糖等的结构，R'和R“是具有 一至四个碳原子，其中R'和R“可以是相同或不同的烷基。 已经发现本发明的化合物作为抗细菌剂和抗真菌剂特别有效，并且抑制动物组织中的癌细胞生长。

    Phenylazophenyl dyestuff
    4.
    发明授权
    Phenylazophenyl dyestuff 失效
    苯基苯基染料

    公开(公告)号：US3939142A

    公开(公告)日：1976-02-17

    申请号：US495191

    申请日：1974-08-06

    申请人： Erwin Fleckenstein

    发明人： Erwin Fleckenstein

    IPC分类号： C07D213/85 ,  C09B29/00 ,  C09B44/02 ,  C09B62/51 ,  D06P1/90 ,  C07C115/00

    CPC分类号： C09B44/02 ,  C09B29/00 ,  D06P1/908

    摘要： Basic azo dyestuffs, free from sulfo groups and having the formulaWherein Z is the radical of a tertiary amino group or of a quaternary ammonium group, Alk is alkylene of two to five carbon atoms, X is oxygen, Ar is phenylene unsubstituted or substituted by alkyl of one to four carbon atoms, alkoxy of one to four carbon atoms and/or chlorine or bromine, and K as the radical of a coupling component is the radical of a tertiary amine of the benzene series, the radical of 2,6-diamino-3-cyano-4-methyl pyridine or a derivative thereof or the radical of the 2-hydroxynaphthalene series, which are suitable for the preparation of writing and stamping inks or pastes for ball-point pens as well as suitable in offset printing and for the dyeing, printing or mass dyeing of, for example, tannined cellulose fibers, silk, hair, leather, acetate silk, polyamide fibers or acid modified polyolefins, polyamide or polyester fibers and fibers containing polyacrylonitrile or polyvinylidene cyanide. The dyeings obtained on these fibers have, in general, a high color intensity and, in general, good fastness to light and to wet processing. The dyestuffs can be used in slightly acid and strongly acid baths and are stable at a temperature above 100.degree.C as used in high-temperature dyeing. Wool is completely reserved by the dyestuffs under normal dyeing conditions.

    摘要翻译： 碱性偶氮染料，不含磺基，具有式WHEREIN Z为叔氨基或季铵基团的基团，Alk为2至5个碳原子的亚烷基，X为氧，Ar为未取代的苯基或被 1-4个碳原子的烷基，1-4个碳原子的烷氧基和/或氯或溴，作为偶合组分基团的K是苯系的叔胺基团， 二氨基-3-氰基-4-甲基吡啶或其衍生物或2-羟基萘系列的基团，其适用于制备用于圆珠笔的书写和冲压油墨或糊料，以及适用于胶版印刷和 用于例如单宁纤维素纤维，丝绸，毛发，皮革，醋酸丝，聚酰胺纤维或酸改性聚烯烃，聚酰胺或聚酯纤维和含有聚丙烯腈或聚偏二氰乙烯的纤维的染色，印花或大量染色。 在这些纤维上获得的染色通常具有高的颜色强度，并且通常具有良好的耐光牢度和湿润的加工性。 该染料可用于轻酸和强酸浴中，并且在高温染色中使用的高于100℃的温度下是稳定的。 在正常染色条件下，羊毛完全由染料保留。

    Precursors to radiopharmaceutical agents for tissue imaging
    5.
    发明授权
    Precursors to radiopharmaceutical agents for tissue imaging 失效
    用于组织成像的放射性药剂的前体

    公开(公告)号：US4764598A

    公开(公告)日：1988-08-16

    申请号：US25703

    申请日：1987-03-13

    申请人： Prem C. Srivastava ,  Furn F. Knapp, Jr.

    发明人： Prem C. Srivastava ,  Furn F. Knapp, Jr.

    IPC分类号： C07D213/82 ,  C07C115/00 ,  C09B56/20

    CPC分类号： C07D213/82

    摘要： A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.

    摘要翻译： 一类用于组织成像的放射性标记化合物，其显示出快速的脑摄取，良好的脑：血液放射性比率和长的保留时间。 成像剂更具体地是连接到二氢吡啶载体的放射性碘化芳族胺，其表现出心脏以及脑特异性。 除了放射性标记的化合物之外，还描述了在制备显像剂中用作前体和中间体的化合物类别。

    Treatment of aromatic amines with gas mixtures derived from the oxidation of ammonia to effect diazotization/coupling
    6.
    发明授权
    Treatment of aromatic amines with gas mixtures derived from the oxidation of ammonia to effect diazotization/coupling 失效
    用来自氨氧化的气体混合物处理芳香胺进行重氮化/偶联

    公开(公告)号：US4020052A

    公开(公告)日：1977-04-26

    申请号：US635059

    申请日：1975-11-25

    申请人： John Kent Detrick

    发明人： John Kent Detrick

    IPC分类号： C01B21/26 ,  C07C20060101 ,  C07C113/00 ,  C07C115/00

    摘要： 1,3-Diaryl triazenes, e.g., 1,3-diphenyltriazene, intermediates in the synthesis of aromatic diamines, e.g., p-phenylenediamine, are prepared by catalytically oxidizing ammonia, and subsequently the resulting nitric oxide, with a gas comprising diluted molecular oxygen, e.g., air, so as to produce a gas mixture containing dilute NO.sub.x, i.e., NO.sub.2 preferably admixed with NO, x being (1 + n), wherein n is the NO.sub.2 fraction of the NO.sub.x ; and contacting the gas mixture, preferably at a temperature in the range of about from 25.degree. to 350.degree. C., with excess primary aromatic monoamine, e.g., aniline, so as to result in a monoamine temperature in the range of about from 25.degree. to 90.degree. C., preferably 40.degree. to 60.degree. C., during contact. Highest yields of triazene are obtained when the x in NO.sub.x is about from 1.3 to 1.7, and the amount of NO.sub.x gas mixture contacted with the monoamine and the time of contact are such that at least about 60% by weight of the monoamine remains unconsumed. A gas mixture temperature just prior to gas contact with the liquid monoamine in the range of about from 110.degree. to 275.degree. C. is more preferred under certain circumstances.

    摘要翻译： 1,3-二芳基三氮烯，例如1,3-二苯基三氮烯，芳基二胺合成中的中间体，例如对苯二胺，通过催化氧化氨，随后产生的一氧化氮与包含稀释的分子氧 例如空气，以便产生含有稀释的NOx的气体混合物，即NO 2优选与NO混合，x为（1 + n），其中n为NO x的NO 2分数; 并且将气体混合物优选在约25℃至350℃的温度下与过量的伯芳基单胺例如苯胺接触，以使单胺温度在约25℃的范围内 至90℃，优选40℃至60℃。 当x x约为1.3至1.7时，获得三氮烯的最高产率，并且与单胺接触的NOx气体混合物的量和接触时间使得至少约60重量％的单胺保持未消耗。 在某些情况下，更优选在与液体单胺气体接触之前的气体混合物温度在约110℃至275℃的范围内。

    2-Alkyl-4-carboxyalkyl-5-(3,3'-dimethyltriazeno)-imidazoles
    8.
    发明授权
    2-Alkyl-4-carboxyalkyl-5-(3,3'-dimethyltriazeno)-imidazoles 失效
    2-烷基-4-羧基烷基-5-（3,3（40-二甲基三氮烯） - 咪唑

    公开(公告)号：US3997518A

    公开(公告)日：1976-12-14

    申请号：US527581

    申请日：1974-11-27

    申请人： James Heyes ,  Neal Ward

    发明人： James Heyes ,  Neal Ward

    IPC分类号： C07D233/52 ,  C07D233/90 ,  C07C115/00

    CPC分类号： C07D233/52 ,  C07D233/90

    摘要： Imidazoles of the formula: ##STR1## and their salts, wherein R.sub.1 is an optically substituted hydrocarbon, heterocyclic or thiol group; R.sub.2 is an amino or optionally substituted etherified hydroxyl group; R.sub.11 is a negative charge or alkyl group when R.sub.10 is N.sub.2 + or R.sub.11 is a hydrogen atom or alkyl group when R.sub.10 is N = N -- NR.sub.3 R.sub.4 where R.sub.3 is methyl or .beta.-chloroethyl and R.sub.4 is optionally substituted hydrocarbon. When R.sub.10 is N.sub.2 + the compounds are useful as intermediates in the synthesis of compounds wherein R.sub.10 is N=N-- NR.sub.3 R.sub.4 these latter compounds possessing anti-tumor and/or anti-microbial activity.

    摘要翻译： 式：咪唑类及其盐，其中R1是光学取代的烃，杂环或硫醇基; R2是氨基或任选取代的醚化羟基; 当R 10为N = N-NR 3 R 4时，当R 10为N 2 +或R 11为氢原子或烷基时，R 11为负电荷或烷基，其中R 3为甲基或β-氯乙基且R 4为任选取代的烃。 当R 10是N 2 +时，化合物可用作合成其中R 10为N = NR-NR 3 R 4的化合物的中间体，这些后者具有抗肿瘤和/或抗微生物活性。