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70 条记录 (耗时 0.018 秒)

    Compositions and methods of treatment using peat derivatives
    1.
    发明授权
    Compositions and methods of treatment using peat derivatives 失效
    使用泥炭衍生物的组合物和处理方法

    公开(公告)号：US06267962B1

    公开(公告)日：2001-07-31

    申请号：US08885323

    申请日：1997-06-30

    申请人： Ralph M. Hart ,  Herman L. Jones ,  Veronica Lee Egelkrout Jones ,  Sohail Malik ,  Margaret A. Kenny ,  Bernard Loev ,  James P. Harnisch

    发明人： Ralph M. Hart ,  Herman L. Jones ,  Veronica Lee Egelkrout Jones ,  Sohail Malik ,  Margaret A. Kenny ,  Bernard Loev ,  James P. Harnisch

    IPC分类号： A61K3578

    CPC分类号： A61K33/30 ,  A61K33/06 ,  A61K33/14 ,  A61K33/24 ,  A61K33/32 ,  A61K33/34 ,  Y10S514/825 ,  Y10S514/858 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/886 ,  A61K2300/00

    摘要： Novel compositions containing at least one biologically active component derived from peat or similar composition, methods for their preparation and therapeutic uses for a variety of diseases, injuries, and conditions, including wound healing, pain, itch, inflammation, abnormal cell proliferation, or infections caused by fungal, bacterial, rickettsial or viral agents, psoriasis, allergic and other dermatitis, pruritis, eczema, actinic keratosis and similar conditions. In addition, the compositions can be used as diuretics, antiarrhythmics, and cardiac-stimulating agents, as well as for the treatment of mammalian diseases and disorders, including multiple drug resistance, cancers, asthma, rheumatoid arthritis, pain, wound healing, fungal disorders, and other inflammatory disorders. The compositions are derivable from peat or peat-related substances and may alternatively be synthetically produced.

    摘要翻译： 含有至少一种衍生自泥炭或类似组合物的生物活性成分的新型组合物，其制备方法以及用于各种疾病，损伤和病症（包括伤口愈合，疼痛，瘙痒，炎症，异常细胞增殖或感染）的治疗用途 由真菌，细菌，立克次体或病毒药物引起的，牛皮癣，过敏性和其它皮炎，瘙痒症，湿疹，光化性角化病和类似的病症。 此外，组合物可用作利尿剂，抗心律失常药和心脏刺激剂，以及用于治疗哺乳动物疾病和病症，包括多重耐药性，癌症，哮喘，类风湿性关节炎，疼痛，伤口愈合，真菌性疾病 ，和其他炎性疾病。 所述组合物可衍生自泥炭或泥煤相关物质，并且可以合成地制备。

    Unsaturated oxyalkylene esters and uses thereof
    2.
    发明授权
    Unsaturated oxyalkylene esters and uses thereof 失效
    不饱和氧化烯酯及其用途

    公开(公告)号：US6124495A

    公开(公告)日：2000-09-26

    申请号：US814366

    申请日：1997-03-11

    申请人： Edward Neiss ,  Bernard Loev

    发明人： Edward Neiss ,  Bernard Loev

    IPC分类号： C07C69/618 ,  C07C69/65 ,  C07C69/734 ,  C07C69/76

    CPC分类号： C07C69/65 ,  C07C69/618 ,  C07C69/734

    摘要： This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dependent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, modulating gene expression and particularly augmenting expression of a tumor suppressor gene and inducing tolerance to an antigen. The methods of the invention use unsaturated oxyalkylene esters.

    摘要翻译： 本发明涉及治疗，预防或改善癌症和其它增殖性疾病的组合物和方法，以及诱导伤口愈合，治疗皮肤溃疡，治疗胃肠道疾病，治疗血液病症如贫血，免疫调节，增强重组基因表达的方法， 治疗胰岛素依赖患者，治疗囊性纤维化患者，抑制端粒酶活性，治疗病毒相关肿瘤，特别是EBV相关肿瘤，调节基因表达，特别是增加肿瘤抑制基因的表达并诱导对抗原的耐受性。 本发明的方法使用不饱和氧化烯酯。

    Methotrexate compositions and methods of treatment using same
    3.
    发明授权
    Methotrexate compositions and methods of treatment using same 失效
    甲氨蝶呤组合物和使用其的治疗方法

    公开(公告)号：US5166149A

    公开(公告)日：1992-11-24

    申请号：US713558

    申请日：1991-06-10

    申请人： Bernard Loev

    发明人： Bernard Loev

    IPC分类号： A61K31/555

    CPC分类号： A61K31/555

    摘要： Compositions containing metal salts of methotrexate and methotrexate derivatives or analogs are disclosed. Such compositions comprise a metal salt, preferably a zinc salt, of methotrexate or a methotrexate derivative or analog and a carrier suitable for delivering the metal salt in the desired pharmacological form. Methods of treatment are also disclosed in which such compositions are topically applied or orally or parenterally administered to a patient. The metal salt is present in the treating composition in an amount sufficient to produce the desired therapeutic effect upon application or administration.

    摘要翻译： 公开了含有甲氨蝶呤和甲氨蝶呤衍生物或类似物的金属盐的组合物。 这样的组合物包含甲氨蝶呤或甲氨蝶呤衍生物或类似物的金属盐，优选锌盐，和适于递送所需药理学形式的金属盐的载体。 还公开了治疗方法，其中这些组合物被局部施用或口服或肠胃外给药给患者。 金属盐以足以在施用或施用时产生所需治疗效果的量存在于处理组合物中。

    Antihypertensive lactams
    4.
    发明授权
    Antihypertensive lactams 失效
    抗高血压内酰胺

    公开(公告)号：US4766210A

    公开(公告)日：1988-08-23

    申请号：US288134

    申请日：1981-07-29

    申请人： John T. Suh ,  Bruce E. Williams ,  Jerry W. Skiles ,  Bernard Loev

    发明人： John T. Suh ,  Bruce E. Williams ,  Jerry W. Skiles ,  Bernard Loev

    IPC分类号： C07D277/06 ,  C07D279/12 ,  C07D281/06 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D277/06 ,  C07D279/12 ,  C07D281/06

    摘要： Antihypertensive compounds of the structure ##STR1## wherein: n is an integer from 0 to 2 inclusive,R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are independently hydrogen, alkyl having from 1 to 6 carbon atoms, alkenyl having from 2 to 6 carbon atoms, alkynyl having from 2 to 6 carbon atoms, cycloalkyl having from 3 to 16 carbon atoms, phenyl, benzyl, tolyl, naphthyl, phenethyl, indanyl, tetrahydronaphthyl, decahydronaphthyl, pyridyl, quinolyl, pyrrolidyl, pyrrolyl, morpholinyl, thiomorpholinyl, furyl, furfuryl, tetrahydrofurfuryl, benzimidazole, thienyl, imidolyl, or tetrahydroindolyl, and where the R.sub.1 to R.sub.7 groups are alkyl, said groups carrying a substituent selected from hydroxy, alkoxy, amino, carboxy, or carbalkoxy, the alkyl group in alkoxy and carbalkoxy having from 1 to 6 carbon atoms, or R.sub.2 taken together with R.sub.3 and the carbons to which they are attached is tetrahydronapthyl or phenyl, and when phenyl R.sub.1 and R.sub.4 are absent, or R.sub.6 and R.sub.7 taken together with the carbon to which R.sub.6 is attached and the nitrogen to which R.sub.7 is attached form a heterocycle selected from pyrrolidyl, thiazolidine, tetrahydro-isoquinoline, thiomorpholine, or 2,2,5,5-tetramethylthiazolidinie, andY is .dbd.O, .dbd.S, .dbd.NR.sub.1, .dbd.NOR.sub.1 or .dbd.N--NH.sub.2, R.sub.1 being the same as defined above.

    摘要翻译： 结构的抗高血压化合物其中：n为0〜2的整数，R1，R2，R3，R4，R5，R6和R7独立地为氢，具有1-6个碳原子的烷基， 2至6个碳原子，具有2至6个碳原子的炔基，具有3至16个碳原子的环烷基，苯基，苄基，甲苯基，萘基，苯乙基，茚满基，四氢萘基，十氢萘基，吡啶基，喹啉基，吡咯烷基，吡咯基，吗啉基， 硫代吗啉基，呋喃基，糠基，四氢糠基，苯并咪唑，噻吩基，亚氨基或四氢吲哚基，其中R 1至R 7基团是烷基，所述基团含有选自羟基，烷氧基，氨基，羧基或烷氧基的取代基，烷氧基 和具有1至6个碳原子的烷氧基，或者R 2与R 3和它们所连接的碳一起是四氢萘基或苯基，当R 1和R 4不存在时，或者R 6和R 7与R 6一起 附上 并且R 7连接的氮形成选自吡咯烷基，噻唑烷，四氢 - 异喹啉，硫代吗啉或2,2,5,5-四甲基噻唑烷的杂环，Y = O，= S，= NR1，= NOR1或 = N-NH 2，R 1与上述定义相同。

    Polyene compounds useful in the treatment of allergic responses
    7.
    发明授权
    Polyene compounds useful in the treatment of allergic responses 失效
    可用于治疗过敏反应的多烯化合物

    公开(公告)号：US4605675A

    公开(公告)日：1986-08-12

    申请号：US787843

    申请日：1985-10-16

    申请人： Bernard Loev ,  Wan-Kit Chan

    发明人： Bernard Loev ,  Wan-Kit Chan

    IPC分类号： A61K31/05 ,  A61K31/075 ,  A61K31/085

    CPC分类号： C07C403/02 ,  C07C2101/16

    摘要： Polyene compounds represented by the formula ##STR1## in which R is H or an alkyl group of from 1 to 5 carbon atoms, R.sub.1 is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl, and the pharmaceutically acceptable salts thereof.The foregoing compounds have been found active in regulating phospholipases and as such possess therapeutic value in the treatment of inflammatory conditions.

    摘要翻译： 其中R为H或1至5个碳原子的烷基，R 1为H，1至8个碳原子的低级烷基或芳烷基，其化学式为“IMAGE”的多烯化合物及其药学上可接受的盐。 已经发现前述化合物在调节磷脂酶中是有活性的，因此具有治疗炎性病症的治疗价值。

    Antihypertensive pyridines and compositions
    10.
    发明授权
    Antihypertensive pyridines and compositions 失效
    抗高血压吡啶和组合物

    公开(公告)号：US4258042A

    公开(公告)日：1981-03-24

    申请号：US139367

    申请日：1980-04-11

    申请人： Bernard Loev ,  James R. Shroff

    发明人： Bernard Loev ,  James R. Shroff

    IPC分类号： C07D211/90 ,  A61K31/455 ,  A61P9/12 ,  C07D211/30 ,  A61K31/535 ,  C07D295/14

    CPC分类号： C07D211/30

    摘要： Antihypertensive compounds of the formula ##STR1## wherein R.sub.5 is H, alkyl, aryl, halo, lower alkoxy, nitro amino, alkylmercapto, cyano, carboxy, carbalkoxy, sulfamyl, trifluoromethyl, hydroxy, acyloxy, methanesulfonyl, alkylamino or acylamino; and each R.sub.1 and R.sub.2 is alkyl; wherein the alkyl, alkoxy and aryl groups contain up to 10 carbon atoms and non-toxic, pharmaceutically-acceptable acid addition salts thereof.

    摘要翻译： 其中R5是H，烷基，芳基，卤素，低级烷氧基，硝基氨基，烷基巯基，氰基，羧基，烷氧基，氨基磺酰基，三氟甲基，羟基，酰氧基，甲磺酰基，烷基氨基或酰基氨基的抗高血压化合物。 并且每个R 1和R 2是烷基; 其中烷基，烷氧基和芳基含有至多10个碳原子和无毒的药学上可接受的酸加成盐。