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    PROCESS FOR PREPARING N,N'-BIS(2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL)HEXANE-1,6-DIAMINE
    1.
    发明公开
    PROCESS FOR PREPARING N,N'-BIS(2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL)HEXANE-1,6-DIAMINE 审中-公开

    公开(公告)号：US20240182417A1

    公开(公告)日：2024-06-06

    申请号：US18279567

    申请日：2022-02-10

    申请人： BASF SE

    发明人： Alexander Michael HAYDL ,  Michael SCHMITT ,  Elena CAPITO'

    IPC分类号： C07D211/02 ,  C07D251/22

    CPC分类号： C07D211/02 ,  C07D251/22

    摘要： The present invention relates to a process for preparing N,N′-bis(2,2,6,6-tetramethylpiperidin-4-yl)hexane-1,6-diamine. The present invention further relates to the use of N,N′-bis(2,2,6,6-tetramethylpiperidin-4-yl)hexane-1,6-diamine to prepare poly[[6-[(1,1,3,3-tetramethylbutyl)amino]-s-triazine-2,4-diyl]-[(2,2,6,6-tetramethyl-4-piperidyl)imino]-hexamethylene-[(2,2,6,6-tetramethyl-4-piperidyl)imino], reaction material of 1,6-hexanediamine, N,N′-bis (2,2,6,6-tetramethyl-4-piperidine-yl),2,4,6-trichloro-1, 3,5-triazine,N-butyl-1-butylamine, and N-butyl-2,2,6,6-tetramethyl-4-piperidineamine, N,N′-bis(2,2,6,6-tetramethyl-4-piperidyl)-N,N′-diformylhexamethylenediamine, and 1,6-Hexanediamine, N,N′-bis(2,2,6,6-tetramethyl-4-piperidinyl)-, polymer with 2,4-dichloro-6-(4-morpholinyl)-1,3,5-triazine.

    TRIAZINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS
    9.
    发明申请
    TRIAZINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS 有权
    TRIAZINE CARBOXAMIDES作为钠通道阻塞剂

    公开(公告)号：US20140249128A1

    公开(公告)日：2014-09-04

    申请号：US14191269

    申请日：2014-02-26

    申请人： Purdue Pharma L.P.

    发明人： Dawit Tadesse ,  Jianming Yu

    IPC分类号： C07D413/14 ,  C07D413/12 ,  C07D251/22 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

    CPC分类号： C07D413/14 ,  C07D251/22 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12

    摘要： The present disclosure provides substituted triazine carboxamides of Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A1, X, A2, E, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

    摘要翻译： 本公开提供式I的取代的三嗪甲酰胺及其药学上可接受的盐和溶剂化物，其中A1，X，A2，E和Z如说明书所述定义。 本公开还涉及式I化合物用于治疗对钠通道阻断作出反应的病症。 本公开的化合物特别可用于治疗疼痛。